Pathway Component Details
| Name: | Nuclear factor kappa-B (NFkappaB) |
| Definition: | Toll-like receptors (TLRs) play a role in innate immunity to pathogens by sensing microorganisms through structural motifs called pathogen-associated microbial patterns (PAMPs). Stimulation of TLRs by PAMPs initiates a signaling cascade that ultimately leads to the activation of the NF-kB (Nuclear Factor-KappaB). NF-kB is composed of homo- and heterodimers of five members of the Rel family including NF-kB1(p50), NF-kB2 (p52), RelA (p65), RelB, and c-Rel (Rel). NF-kB dimers are sequestered in the cytosol of unstimulated cells via IkBs. TLR stimulation leads to the phosphorylation of IkBs, their dissociation and subsequent degradation, thereby allowing activation of the NF-kB complex and translocation into the nucleus. |
| Category ID: | P01354 |
| Synonyms: | |
| Upstream: |
IkappaB_alpha Kinase
(IKKalpha)
IkappaB_beta kinase (IKKbeta) |
| Downstream: |
Gene trancription
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| Number Families/Subfamilies: | 5 |
| Number of Associated Sequences: | 15 |
| GO Molecular Function: |
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| GO Biological Process: |
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| GO Cellular Component: |
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| PANTHER protein class: |
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| References: |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR24169:SF1 | A0A8I3P3H3 | RELA proto-oncogene, NF-kB subunit | ISS | PubMed:10049353 |
| A0A8I6A5H5 | RELA proto-oncogene, NF-kB subunit | ISS | PubMed:10049353 | |
| A1XG22 | NF-kappaB transcription factor p65 subunit | ISS | PubMed:10049353 | |
| G2HHW9 | RELA proto-onco, NF-kB subunit | ISS | PubMed:10049353 | |
| H9FY23 | RELA proto-onco, NF-kB subunit | ISS | PubMed:10049353 | |
| Q04206 | Transcription factor p65 | ISS | PubMed:10049353 | |
| PTHR24169:SF21 | F7GVU6 | Nuclear factor kappa B subunit 2 | ISS | PubMed:12574369 |
| F7GVU6 | Nuclear factor kappa B subunit 2 | ISS | PubMed:20151924 | |
| F7GVU6 | Nuclear factor kappa B subunit 2 | ISS | PubMed:9133421 | |
| K6ZV11 | Nuclear factor kappa B subunit 2 | ISS | PubMed:12574369 | |
| K6ZV11 | Nuclear factor kappa B subunit 2 | ISS | PubMed:9133421 | |
| Q00653 | Nuclear factor NF-kappa-B p100 subunit | ISS | PubMed:12574369 | |
| Q00653 | Nuclear factor NF-kappa-B p100 subunit | ISS | PubMed:20151924 | |
| Q00653 | Nuclear factor NF-kappa-B p100 subunit | ISS | PubMed:9133421 | |
| Q5U2Z4 | Nuclear factor kappa B subunit 2 | ISS | PubMed:12574369 | |
| Q5U2Z4 | Nuclear factor kappa B subunit 2 | ISS | PubMed:20151924 | |
| Q5U2Z4 | Nuclear factor kappa B subunit 2 | ISS | PubMed:9133421 | |
| Q9WTK5 | Nuclear factor NF-kappa-B p100 subunit | ISS | PubMed:12574369 | |
| Q9WTK5 | Nuclear factor NF-kappa-B p100 subunit | ISS | PubMed:20151924 | |
| Q9WTK5 | Nuclear factor NF-kappa-B p100 subunit | ISS | PubMed:9133421 | |
| PTHR24169:SF25 | P15330 | Embryonic polarity protein dorsal | ISS | PubMed:9510254 |
| PTHR24169:SF4 | P15307 | Proto-oncogene c-Rel | ISS | PubMed:11884420 |
| P15307 | Proto-oncogene c-Rel | ISS | PubMed:9480976 | |
| P16236 | Proto-oncogene c-Rel | ISS | ||
| PTHR24169:SF9 | Q04861 | Nuclear factor NF-kappa-B p105 subunit | ISS | PubMed:12574369 |
| Q04861 | Nuclear factor NF-kappa-B p105 subunit | ISS | PubMed:9133421 |
