avermectin (Q105280358)

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group of stereoisomers
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Language Label Description Also known as
English
avermectin
group of stereoisomers

    Statements

    mass
    818.445256792 dalton
    1 reference
    based on heuristic
    inferred from isomeric SMILES
    chemical formula
    C₄₄H₆₆O₁₄
    0 references
    canonical SMILES
    O=C1OC2CC(OC3(OCC(C)CC3)C2)CC=C(C)C(OC4OC(C)C(OC5OC(C)C(O)C(OC)C5)C(OC)C4)C(C=CC=C6COC7C(O)C(=CC1C67O)C)C
    0 references
    isomeric SMILES
    CO[C@H]1C[C@H](O[C@H]2[C@H](C)OC(O[C@@H]3/C(C)=C\CC4CC(CC5(CC[C@H](C)CO5)O4)OC(=O)C4C=C(C)[C@@H](O)C5OC/C(=C/C=C\C3C)[C@@]45O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O
    0 references
    found in taxon
    Streptomyces avermitilis
    37 references
    stated in
    Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis
    stated in
    Direct proteomic mapping of Streptomyces avermitilis wild and industrial strain and insights into avermectin production
    stated in
    Characterization of SAV7471, a TetR-family transcriptional regulator involved in the regulation of coenzyme A metabolism in Streptomyces avermitilis
    stated in
    Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites
    stated in
    Transcriptomic study for screening genes involved in the oxidative bioconversions of Streptomyces avermitilis
    stated in
    Cloning of the gene encoding avermectin B 5-O-methyltransferase in avermectin-producing Streptomyces avermitilis.
    stated in
    Cytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2).
    stated in
    Overexpression of the ABC transporter AvtAB increases avermectin production in Streptomyces avermitilis.
    stated in
    Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis
    stated in
    Involvement of glucose catabolism in avermectin production by Streptomyces avermitilis
    stated in
    Transposon mutagenesis with IS6100 in the avermectin-producer Streptomyces avermitilis
    stated in
    Engineering the aveC gene to enhance the ratio of doramectin to its CHC-B2 analogue produced in Streptomyces avermitilis
    stated in
    The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis.
    stated in
    Inactivation of the extracytoplasmic function sigma factor Sig6 stimulates avermectin production in Streptomyces avermitilis.
    stated in
    Engineering of the TetR family transcriptional regulator SAV151 and its target genes increases avermectin production in Streptomyces avermitilis
    stated in
    A novel TetR family transcriptional regulator, SAV576, negatively controls avermectin biosynthesis in Streptomyces avermitilis
    stated in
    Effect of a global regulatory gene, afsR2, from Streptomyces lividans on avermectin production in Streptomyces avermitilis.
    stated in
    Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans
    stated in
    Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters
    stated in
    Deletion analysis of the avermectin biosynthetic genes of Streptomyces avermitilis by gene cluster displacement
    stated in
    Nitrogen regulation of fatty acids and avermectins biosynthesis in Streptomyces avermitilis
    stated in
    A second branched-chain alpha-keto acid dehydrogenase gene cluster (bkdFGH) from Streptomyces avermitilis: its relationship to avermectin biosynthesis and the construction of a bkdF mutant suitable for the production of novel antiparasitic avermecti
    stated in
    The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis
    stated in
    Overexpression of ribosome recycling factor causes increased production of avermectin in Streptomyces avermitilis strains.
    stated in
    Transcriptomics analyses reveal global roles of the regulator AveI in Streptomyces avermitilis
    stated in
    Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis.
    stated in
    Overexpression of metK shows different effects on avermectin production in various Streptomyces avermitilis strains
    stated in
    Improvement of transformation and electroduction in avermectin high-producer, Streptomyces avermitilis.
    stated in
    Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase
    stated in
    Two adjacent and similar TetR family transcriptional regulator genes, SAV577 and SAV576, co-regulate avermectin production in Streptomyces avermitilis
    stated in
    Streptomyces avermectinius sp. nov., an avermectin-producing strain
    stated in
    Relationship between volatile odorous substances and production of avermectins by Streptomyces avermitilis.
    stated in
    Transposon mutagenesis by Tn4560 and applications with avermectin-producing Streptomyces avermitilis
    stated in
    SdrA, a new DeoR family regulator involved in Streptomyces avermitilis morphological development and antibiotic production
    stated in
    Directed biosynthesis of avermectins.
    stated in
    A gene cluster for biosynthesis of the sesquiterpenoid antibiotic pentalenolactone in Streptomyces avermitilis
    stated in
    Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites

    Identifiers

     
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