Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons (Q21145800)

PubMed publication ID

20126265

17 August 2022

Michael P Coleman

series ordinal

2

author given names

Michael P

author last names

Coleman

1 reference

PubMed publication ID

20126265

Creative Commons Attribution 4.0 International

17 August 2022

language of work or name

English

0 references

publication date

January 2010

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published in

PLOS Biology

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volume

8

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issue

1

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page(s)

e1000300

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copyright license

start time

26 January 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2811159/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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A local mechanism mediates NAD-dependent protection of axon degeneration

19 March 2017

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Regulation of Wallerian degeneration and nerve growth factor withdrawal-induced pruning of axons of sympathetic neurons by the proteasome and the MEK/Erk pathway

19 March 2017

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Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in vivo

7 April 2017

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Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotide

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Wld S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration

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Wld S protein requires Nmnat activity and a short N-terminal sequence to protect axons in mice

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NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration.

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NAD(+) and axon degeneration revisited: Nmnat1 cannot substitute for Wld(S) to delay Wallerian degeneration

12 September 2017

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Proteasome inhibition arrests neurite outgrowth and causes "dying-back" degeneration in primary culture

12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity.

12 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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30 May 2018

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Nicotinamide mononucleotide adenylyltransferase expression in mitochondrial matrix delays Wallerian degeneration.

30 May 2018

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Resveratrol abolishes resistance to axonal degeneration in slow Wallerian degeneration (WldS) mice: activation of SIRT2, an NAD-dependent tubulin deacetylase.

29 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811159

A rat model of slow Wallerian degeneration (WldS) with improved preservation of neuromuscular synapses

29 November 2018

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29 November 2018

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Mutations in dynein link motor neuron degeneration to defects in retrograde transport

29 November 2018

1 reference

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29 November 2018

1 reference

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WldS mice are resistant to paclitaxel (taxol) neuropathy

29 November 2018

1 reference

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Early vacuolization and mitochondrial damage in motor neurons of FALS mice are not associated with apoptosis or with changes in cytochrome oxidase histochemical reactivity.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811159

The gene for slow Wallerian degeneration (Wld(s)) is also protective against vincristine neuropathy.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811159

Glial cells are increased proportionally in transgenic optic nerves with increased numbers of axons.

29 November 2018

1 reference

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Neurites can remain viable after destruction of the neuronal soma by programmed cell death (apoptosis).

29 November 2018

1 reference

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Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve

29 November 2018

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12 December 2020

Inhibiting axon degeneration and synapse loss attenuates apoptosis and disease progression in a mouse model of motoneuron disease

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12 December 2020

Temperature modulation reveals three distinct stages of Wallerian degeneration

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12 December 2020

The proapoptotic proteins Bax and Bak are not involved in Wallerian degeneration

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12 December 2020

The WldS gene modestly prolongs survival in the SOD1G93A fALS mouse

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12 December 2020

Evidence that Wallerian degeneration and localized axon degeneration induced by local neurotrophin deprivation do not involve caspases

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12 December 2020

Synthesis of beta-tubulin, actin, and other proteins in axons of sympathetic neurons in compartmented cultures

1 reference

12 December 2020

10.1371/JOURNAL.PBIO.1000300

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

20126265

1 reference