Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction (Q24632414)

Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents

Europe PubMed Central

title

Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction (English)

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Gerald I Shulman

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Kitt Falk Petersen

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2

object named as

Kitt Falk Petersen

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author name string

Katsutaro Morino

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1

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language of work or name

English

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publication date

December 2006

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published in

Diabetes

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volume

55 Suppl 2

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issue

5

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page(s)

S9-S15

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cites work

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Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)

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Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1

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Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cdelta

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AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation

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Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes

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Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2

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Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

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14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain

7 April 2017

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Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice

7 April 2017

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PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

7 April 2017

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Critical nodes in signalling pathways: insights into insulin action

7 April 2017

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

7 April 2017

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Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes

7 April 2017

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A central role for JNK in obesity and insulin resistance

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Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes

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Cellular mechanisms of insulin resistance

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Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.

27 September 2017

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Insulin-induced stimulation of JNK and the PI 3-kinase/mTOR pathway leads to phosphorylation of serine 318 of IRS-1 in C2C12 myotubes

27 September 2017

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Role of Rho-kinase in regulation of insulin action and glucose homeostasis.

27 September 2017

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Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the diabetes prevention program: effects of lifestyle intervention and metformin

27 September 2017

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Identification of insulin receptor substrate 1 serine/threonine phosphorylation sites using mass spectrometry analysis: regulatory role of serine 1223.

27 September 2017

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Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute [...]

27 September 2017

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Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes

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Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance

27 September 2017

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PKC-theta knockout mice are protected from fat-induced insulin resistance

27 September 2017

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Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302.

27 September 2017

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Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes

27 September 2017

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Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.

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Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle

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30 May 2018

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Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.

30 May 2018

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19 June 2018

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28 November 2018

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28 November 2018

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Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability.

28 November 2018

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28 November 2018

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Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action

28 November 2018

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Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes

28 November 2018

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28 November 2018

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Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-ce

28 November 2018

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28 November 2018

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Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes

28 November 2018

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28 November 2018

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Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

28 November 2018

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Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

28 November 2018

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5'-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside

28 November 2018

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Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study.

28 November 2018

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Five-hour fatty acid elevation increases muscle lipids and impairs glycogen synthesis in the rat.

28 November 2018

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Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians

28 November 2018

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Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy.

28 November 2018

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Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin

28 November 2018

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12 December 2020

Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects

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12 December 2020

Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo

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12 December 2020

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

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12 December 2020

Identifiers

DOI

10.2337/DB06-S002

1 reference

1 reference

1 reference

PubMed publication ID

17130651

1 reference