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Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA - Wikidata

Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA (Q28587767)

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English	Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA	scientific journal article

Statements

scholarly article

2 references

PubMed publication ID

31 January 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21159964%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA (English)

2 references

PubMed publication ID

31 January 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21159964%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

endoplasmic reticulum

0 references

apoptotic process

0 references

Activating transcription factor 4

1 reference

GOA release 2020-03-11

BCL2 binding component 3

1 reference

GOA release 2020-03-11

DNA-damage inducible transcript 3

1 reference

GOA release 2020-03-11

BCL2-like 11 (apoptosis facilitator)

1 reference

GOA release 2020-03-11

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21159964%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

author name string

Zohreh Galehdar

1

2 references

PubMed publication ID

31 January 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21159964%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Patrick Swan

2

2 references

PubMed publication ID

31 January 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21159964%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Benjamin Fuerth

3

2 references

PubMed publication ID

31 January 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21159964%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Steven M Callaghan

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21159964%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Sean P Cregan

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21159964%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

language of work or name

0 references

publication date

1 December 2010

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21159964%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

full work available at URL

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634926

0 references

Journal of Neuroscience

2 references

PubMed publication ID

31 January 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21159964%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

30

2 references

PubMed publication ID

31 January 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21159964%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

50

2 references

PubMed publication ID

31 January 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21159964%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

16938-16948

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21159964%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Perk is essential for translational regulation and cell survival during the unfolded protein response

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA damage-induced neural precursor cell apoptosis requires p53 and caspase 9 but neither Bax nor caspase 3

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulated translation initiation controls stress-induced gene expression in mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stress-inducible transcription factor CHOP/gadd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein aggregation after focal brain ischemia and reperfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent kinases and P53 pathways are activated independently and mediate Bax activation in neurons after DNA damage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microarray analysis of hippocampal gene expression in global cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PUMA induces the rapid apoptosis of colorectal cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PUMA, a novel proapoptotic gene, is induced by p53

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BH3-only proteins - evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ischemia-induced neuronal cell death is mediated by the endoplasmic reticulum stress pathway involving CHOP

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear factor-(kappa)B modulates the p53 response in neurons exposed to DNA damage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of neuronal death by ER stress in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebral ischemia and the unfolded protein response

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 activation domain 1 is essential for PUMA upregulation and p53-mediated neuronal cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoplasmic reticulum stress response and neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bim is a direct target of a neuronal E2F-dependent apoptotic pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The BH3-only protein Puma is both necessary and sufficient for neuronal apoptosis induced by DNA damage in sympathetic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoplasmic reticulum stress-induced apoptosis requires bax for commitment and Apaf-1 for execution in primary neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoplasmic reticulum stress-induced death of mouse embryonic fibroblasts requires the intrinsic pathway of apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atypical, bidirectional regulation of cadmium-induced apoptosis via distinct signaling of unfolded protein response.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal integration in the endoplasmic reticulum unfolded protein response

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of endoplasmic reticulum stress after middle cerebral artery occlusion in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ER stress triggers apoptosis by activating BH3-only protein Bim

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptotic actions of p53 require transcriptional activation of PUMA and do not involve a direct mitochondrial/cytoplasmic site of action in postnatal cortical neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IRE1 signaling affects cell fate during the unfolded protein response

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA damage and repair: relevance to mechanisms of neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential role of PUMA in delayed death of hippocampal CA1 neurons after transient global cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blinded by the Light: The Growing Complexity of p53

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for p53-mediated modulation of neuronal viability.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early detection of DNA strand breaks in the brain after transient focal ischemia: implications for the role of DNA damage in apoptosis and neuronal cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simplified system for generating recombinant adenoviruses

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective actions of dipyridamole on cultured CNS neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of gadd153 expression through transient cerebral ischemia: evidence that ischemia causes endoplasmic reticulum dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/21159964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.1598-10.2010

2 references

PubMed publication ID

31 January 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21159964%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21159964%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

2 references

PubMed publication ID

31 January 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21159964%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

ResearchGate publication ID

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