Stats: transcriptional control and biological impact (Q29547776)

Europe PubMed Central

title

Stats: transcriptional control and biological impact (English)

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23 April 2017

author name string

Levy DE

series ordinal

1

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23 April 2017

Darnell JE Jr

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2

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12209125

23 April 2017

language of work or name

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23 April 2017

publication date

September 2002

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Nature Reviews Molecular Cell Biology

23 April 2017

published in

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23 April 2017

volume

3

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23 April 2017

issue

9

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23 April 2017

page(s)

651-62

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The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction

23 April 2017

cites work

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Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha

31 March 2020

1 reference

Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor

31 March 2020

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Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

31 March 2020

1 reference

How cells respond to interferons

31 March 2020

1 reference

Jaks, STATs, cytokine signal transduction, and immunoregulation: are we there yet?

31 March 2020

1 reference

STAT proteins and transcriptional responses to extracellular signals

31 March 2020

1 reference

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

31 March 2020

1 reference

Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process

31 March 2020

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JAKs, STATs and Src kinases in hematopoiesis

31 March 2020

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An amino acid substitution in the Drosophila hopTum-l Jak kinase causes leukemia-like hematopoietic defects.

31 March 2020

1 reference

The roles of the Drosophila JAK/STAT pathway

31 March 2020

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Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain

31 March 2020

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A Stat3-interacting protein (StIP1) regulates cytokine signal transduction

31 March 2020

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The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor

31 March 2020

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Human Elongator facilitates RNA polymerase II transcription through chromatin

31 March 2020

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Biomolecular interaction analysis of IFN gamma-induced signaling events in whole-cell lysates: prevalence of latent STAT1 in high-molecular weight complexes

31 March 2020

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How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene

31 March 2020

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Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA

31 March 2020

1 reference

Cellular physiology of STAT3: Where's the cytoplasmic monomer?

31 March 2020

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ISGF3 gamma p48, a specificity switch for interferon activated transcription factors

31 March 2020

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Isolation and characterization of a human STAT1 gene regulatory element. Inducibility by interferon (IFN) types I and II and role of IFN regulatory factor-1.

31 March 2020

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Serine phosphorylation of STATs

31 March 2020

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Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane

31 March 2020

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Cytokine signaling: STATS in plasma membrane rafts

31 March 2020

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A weak signal for strong responses: interferon-alpha/beta revisited

31 March 2020

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The caveolin triad: caveolae biogenesis, cholesterol trafficking, and signal transduction

31 March 2020

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SOCS proteins: negative regulators of cytokine signaling

31 March 2020

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Inhibition of IL-2-induced Jak-STAT signaling by glucocorticoids

31 March 2020

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Inhibition of interleukin 2 signaling and signal transducer and activator of transcription (STAT)5 activation during T cell receptor-mediated feedback inhibition of T cell expansion

31 March 2020

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Activation of protein kinase A inhibits interferon induction of the Jak/Stat pathway in U266 cells

31 March 2020

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STATs and gene regulation

31 March 2020

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Three-dimensional structure of the Stat3beta homodimer bound to DNA

31 March 2020

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Dissociation time from DNA determines transcriptional function in a STAT1 linker mutant

31 March 2020

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Structure of the amino-terminal protein interaction domain of STAT-4

31 March 2020

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Role of the Stat4 N domain in receptor proximal tyrosine phosphorylation

31 March 2020

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Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain

31 March 2020

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Functional importance of Stat3 tetramerization in activation of the alpha 2-macroglobulin gene

31 March 2020

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The significance of tetramerization in promoter recruitment by Stat5.

31 March 2020

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Amino-terminal signal transducer and activator of transcription (STAT) domains regulate nuclear translocation and STAT deactivation.

31 March 2020

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Enhancement of antiproliferative activity of gamma interferon by the specific inhibition of tyrosine dephosphorylation of Stat1.

31 March 2020

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Nucleocytoplasmic transport: the soluble phase

31 March 2020

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Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rch1

31 March 2020

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Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alpha

31 March 2020

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Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5

31 March 2020

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Arginine/lysine-rich structural element is involved in interferon-induced nuclear import of STATs

31 March 2020

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Constitutive and IFN-gamma-induced nuclear import of STAT1 proceed through independent pathways

31 March 2020

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Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases

31 March 2020

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Nuclear export signal located within theDNA-binding domain of the STAT1transcription factor

31 March 2020

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Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain

31 March 2020

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A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1.

31 March 2020

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The T-cell protein tyrosine phosphatase

31 March 2020

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Identification of a nuclear Stat1 protein tyrosine phosphatase

31 March 2020

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A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus

31 March 2020

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The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3

31 March 2020

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A cytosolic protein-tyrosine phosphatase PTP1B specifically dephosphorylates and deactivates prolactin-activated STAT5a and STAT5b

31 March 2020

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Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway

31 March 2020

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Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1

31 March 2020

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Regulation of interferon-alpha responsiveness by the duration of Janus kinase activity

31 March 2020

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Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

31 March 2020

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The carboxyl terminus of the granulocyte colony-stimulating factor receptor, truncated in patients with severe congenital neutropenia/acute myeloid leukemia, is required for SH2-containing phosphatase-1 suppression of Stat activation

31 March 2020

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PTP1B regulates leptin signal transduction in vivo

31 March 2020

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Negative regulation of the JAK/STAT pathway

31 March 2020

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A new protein containing an SH2 domain that inhibits JAK kinases

31 March 2020

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Structure and function of a new STAT-induced STAT inhibitor

31 March 2020

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Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for Th cell lineage commitment and maintenance

31 March 2020

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Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1).

31 March 2020

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The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo

31 March 2020

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SOCS3 is essential in the regulation of fetal liver erythropoiesis

31 March 2020

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Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3

31 March 2020

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SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation

31 March 2020

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Specific inhibition of Stat3 signal transduction by PIAS3

31 March 2020

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Modulation of STAT signaling by STAT-interacting proteins

31 March 2020

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Polarity determination in the Drosophila eye: a novel role for unpaired and JAK/STAT signaling

31 March 2020

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A Drosophila PIAS homologue negatively regulates stat92E

31 March 2020

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A new RING for SUMO: wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases

31 March 2020

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Specific ablation of Stat3beta distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock

31 March 2020

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Identification of a Stat gene that functions in Drosophila development

31 March 2020

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Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs

31 March 2020

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Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity

31 March 2020

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DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites

31 March 2020

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Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays

31 March 2020

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Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription

31 March 2020

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Cooperation of the transcriptional coactivators CBP and p300 with Stat6

31 March 2020

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Acetylation by histone acetyltransferase CREB-binding protein/p300 of STAT6 is required for transcriptional activation of the 15-lipoxygenase-1 gene

31 March 2020

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STAT3 acts as a co-activator of glucocorticoid receptor signaling

31 March 2020

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Antiviral response in cells containing Stat1 with heterologous transactivation domains

31 March 2020

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Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation

31 March 2020

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Stat protein transactivation domains recruit p300/CBP through widely divergent sequences

31 March 2020

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IFN-Stimulated transcription through a TBP-free acetyltransferase complex escapes viral shutoff

31 March 2020

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Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells

31 March 2020

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Stat1 depends on transcriptional synergy with Sp1.

31 March 2020

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Activation of the MHC class II transactivator CIITA by interferon-gamma requires cooperative interaction between Stat1 and USF-1

31 March 2020

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Functional interactions between Stat5 and the glucocorticoid receptor

31 March 2020

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Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50.

31 March 2020

1 reference

Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling

31 March 2020

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Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3

31 March 2020

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Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300

31 March 2020

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Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways

31 March 2020

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Kinetics of a gamma interferon response: expression and assembly of CIITA promoter IV and inhibition by methylation

31 March 2020

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Mutations affecting segment number and polarity in Drosophila

31 March 2020

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Identification of the first invertebrate interleukin JAK/STAT receptor, the Drosophila gene domeless

31 March 2020

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A JAK-STAT pathway regulates wing vein formation in Drosophila

31 March 2020

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Control of stem cell self-renewal in Drosophila spermatogenesis by JAK-STAT signaling

31 March 2020

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Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue

31 March 2020

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Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila

31 March 2020

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Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses

31 March 2020

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Stat5a is mandatory for adult mammary gland development and lactogenesis.

31 March 2020

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Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction

31 March 2020

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Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts

31 March 2020

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Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

31 March 2020

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Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5.

31 March 2020

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Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

31 March 2020

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Roles of STAT3 defined by tissue-specific gene targeting

31 March 2020

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31 March 2020

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Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

31 March 2020

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Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway

31 March 2020

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Immune response in Stat2 knockout mice

31 March 2020

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Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation

31 March 2020

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Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liver

31 March 2020

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Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.

31 March 2020

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The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion

31 March 2020

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Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak/Stat pathway

31 March 2020

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Selective STAT protein degradation induced by paramyxoviruses requires both STAT1 and STAT2 but is independent of alpha/beta interferon signal transduction

31 March 2020

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The V protein of human parainfluenza virus 2 antagonizes type I interferon responses by destabilizing signal transducer and activator of transcription 2.

31 March 2020

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Longer and shorter forms of Sendai virus C proteins play different roles in modulating the cellular antiviral response

31 March 2020

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Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response

31 March 2020

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Vesicular stomatitis virus matrix protein inhibits host cell gene expression by targeting the nucleoporin Nup98

31 March 2020

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Inhibition of Ran guanosine triphosphatase-dependent nuclear transport by the matrix protein of vesicular stomatitis virus

31 March 2020

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Role of nucleoporin induction in releasing an mRNA nuclear export block

31 March 2020

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Oncogenic kinase signalling

31 March 2020

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Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice

31 March 2020

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STAT1 affects lymphocyte survival and proliferation partially independent of its role downstream of IFN-gamma

31 March 2020

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Distinct requirements for IFNs and STAT1 in NK cell function

31 March 2020

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IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity

31 March 2020

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31 March 2020

STAT Proteins and Cancer

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31 March 2020

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31 March 2020

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STAT signaling in head and neck cancer

31 March 2020

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Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma

31 March 2020

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Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins

31 March 2020

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Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor

31 March 2020

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ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases

31 March 2020

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Activation of Stat3 preassembled with platelet-derived growth factor beta receptors requires Src kinase activity

31 March 2020

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Role of G beta-subunit in angiotensin II-type 1 receptor signaling

31 March 2020

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Thrombin regulates vascular smooth muscle cell growth and heat shock proteins via the JAK-STAT pathway

31 March 2020

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Involvement of JAK/STAT (Janus kinase/signal transducer and activator of transcription) in the thyrotropin signaling pathway

31 March 2020

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Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein

31 March 2020

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Activation and association of Stat3 with Src in v-Src-transformed cell lines

31 March 2020

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Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor

31 March 2020

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Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling

31 March 2020

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Complex roles of Stat1 in regulating gene expression

31 March 2020

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Stat1-dependent and -independent pathways in IFN-gamma-dependent signaling

31 March 2020

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Inhibition of basal transcription by poliovirus: a virus- encoded protease (3Cpro) inhibits formation of TBP-TATA box complex in vitro

31 March 2020

1 reference

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Consolidated OpenCitations Corpus – April 2017

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23 April 2017

Consolidated OpenCitations Corpus – April 2017