Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis (Q33987248)

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5 February 2020

title

Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis (English)

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Jaehoon Kim

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Sarah J Whitcomb

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Alexander J Ruthenburg

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Kojo Elenitoba-Johnson

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C David Allis

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author name string

Gang G Wang

3

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Sonja C Stadler

4

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Venkatesha Basrur

5

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Zhanxin Wang

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Robert G Roeder

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publication date

10 June 2010

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volume

38

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issue

6

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page(s)

853-863

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The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS

5 February 2020

cites work

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MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.

5 July 2018

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AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia

5 July 2018

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A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription

5 July 2018

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Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia.

5 July 2018

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Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II.

5 July 2018

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Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger

5 July 2018

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RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells

5 July 2018

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Chromatin immunoprecipitation (ChIP) for analysis of histone modifications and chromatin-associated proteins.

5 July 2018

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Developmental roles of the histone lysine demethylases

5 July 2018

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HOXA9 is required for survival in human MLL-rearranged acute leukemias

5 July 2018

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H3K79 methylation profiles define murine and human MLL-AF4 leukemias

5 July 2018

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Menin critically links MLL proteins with LEDGF on cancer-associated target genes

5 July 2018

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Multivalent engagement of chromatin modifications by linked binding modules

5 July 2018

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Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes

5 July 2018

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MLL translocations, histone modifications and leukaemia stem-cell development

5 July 2018

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Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark

5 July 2018

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Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth

5 July 2018

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Transcription of bxd noncoding RNAs promoted by trithorax represses Ubx in cis by transcriptional interference

5 July 2018

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Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases

5 July 2018

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Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferase

5 July 2018

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Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development

5 July 2018

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MLL associates specifically with a subset of transcriptionally active target genes

5 July 2018

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Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF

5 July 2018

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Mechanisms of transformation by MLL.

5 July 2018

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The parafibromin tumor suppressor protein is part of a human Paf1 complex

5 July 2018

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Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

5 July 2018

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MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein

5 July 2018

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The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation

5 July 2018

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Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity

5 July 2018

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5 July 2018

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MLL targets SET domain methyltransferase activity to Hox gene promoters

5 July 2018

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Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

5 July 2018

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Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia

5 July 2018

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Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2.

5 July 2018

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Overlapping roles of the methylated DNA-binding protein MBD1 and polycomb group proteins in transcriptional repression of HOXA genes and heterochromatin foci formation

29 October 2018

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Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications

29 October 2018

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10.1016/J.MOLCEL.2010.05.011

29 October 2018

Identifiers

DOI

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5 February 2020

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5 February 2020

PubMed publication ID

20541448

1 reference