TNF receptor associated factor 6 (Q4050614)

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mammalian protein found in Homo sapiens
  • E3 ubiquitin-protein ligase TRAF6
  • TNF receptor-associated factor 6
  • RING finger protein 85
  • interleukin-1 signal transducer
  • RING-type E3 ubiquitin transferase TRAF6
  • TNF receptor-associated factor 6, E3 ubiquitin protein ligase
  • TRAF6
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Language Label Description Also known as
English
TNF receptor associated factor 6
mammalian protein found in Homo sapiens
  • E3 ubiquitin-protein ligase TRAF6
  • TNF receptor-associated factor 6
  • RING finger protein 85
  • interleukin-1 signal transducer
  • RING-type E3 ubiquitin transferase TRAF6
  • TNF receptor-associated factor 6, E3 ubiquitin protein ligase
  • TRAF6

Statements

molecular function
protein binding
determination method
IPI
62 references
retrieved
8 April 2019
stated in
NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6
GOA
curator
UniProt
UniProt protein ID
Q9Y4K3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta
GOA
curator
UniProt
UniProt protein ID
Q9Y4K3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
WDFY1 mediates TLR3/4 signaling by recruiting TRIF
GOA
curator
UniProt
UniProt protein ID
Q9Y4K3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor
GOA
curator
UniProt
UniProt protein ID
Q9Y4K3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation
GOA
curator
UniProt
UniProt protein ID
Q9Y4K3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes
GOA
curator
UniProt
UniProt protein ID
Q9Y4K3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability
GOA
curator
UniProt
UniProt protein ID
Q9Y4K3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway
GOA
curator
UniProt
UniProt protein ID
Q9Y4K3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6
GOA
curator
UniProt
UniProt protein ID
Q9Y4K3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Tetraspanin 6 (TSPAN6) negatively regulates retinoic acid-inducible gene I-like receptor-mediated immune signaling in a ubiquitination-dependent manner
GOA
curator
UniProt
UniProt protein ID
Q9Y4K3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner
GOA
curator
UniProt
UniProt protein ID
Q9Y4K3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
TRAF family proteins link PKR with NF-kappa B activation
GOA
curator
UniProt
UniProt protein ID
Q9Y4K3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification
GOA
curator
UniProt
UniProt protein ID
Q9Y4K3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling
GOA
curator
UniProt
UniProt protein ID
Q9Y4K3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
TRAF Family Member-associated NF-κかっぱB Activator (TANK) Inhibits Genotoxic Nuclear Factor κかっぱB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase
GOA
curator
UniProt
UniProt protein ID
Q9Y4K3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
NUMBL interacts with TRAF6 and promotes the degradation of TRAF6
GOA
curator
UniProt
UniProt protein ID
Q9Y4K3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains
GOA
curator
UniProt
UniProt protein ID
Q9Y4K3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1
GOA
curator
UniProt
UniProt protein ID
Q9Y4K3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
INNATE IMMUNITY. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Vaccinia virus protein A52R activates p38 mitogen-activated protein kinase and potentiates lipopolysaccharide-induced interleukin-10
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Distinct molecular mechanism for initiating TRAF6 signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
The germinal center kinase TNIK is required for canonical NF-κかっぱB and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
The UL144 gene product of human cytomegalovirus activates NFkappaB via a TRAF6-dependent mechanism
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
NESCA: a new NEMO/IKKgamma and TRAF6 interacting protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
T6BP, a TRAF6-interacting protein involved in IL-1 signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Isolation and characterization of two novel A20-like proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Protein kinase C-δでるた negatively regulates T cell receptor-induced NF-κかっぱB activation by inhibiting the assembly of CARMA1 signalosome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Direct activation of protein kinases by unanchored polyubiquitin chains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Next-generation sequencing to generate interactome datasets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
E2 interaction and dimerization in the crystal structure of TRAF6
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Sphingosine 1-phosphate as a regulator of osteoclast differentiation and osteoclast-osteoblast coupling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Pooled-matrix protein interaction screens using Barcode Fusion Genetics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Isolation and characterization of two novel A20-like proteins
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
retrieved
8 April 2019
stated in
Equine herpesvirus protein E10 induces membrane recruitment and phosphorylation of its cellular homologue, bcl-10
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IPI
ubiquitin-protein transferase activity
determination method
EXP
IDA
TAS
IEA
8 references
retrieved
5 June 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4K3&geneProductId=UniProtKB:Q9Y4K3
determination method
TAS
retrieved
5 June 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4K3&geneProductId=UniProtKB:Q9Y4K3
determination method
IEA
retrieved
5 June 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4K3&geneProductId=UniProtKB:Q9Y4K3
determination method
IEA
retrieved
5 June 2018
stated in
The E3 ligase TRAF6 regulates Akt ubiquitination and activation
GOA
curator
UniProt
UniProt protein ID
Q9Y4K3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4K3&geneProductId=UniProtKB:Q9Y4K3
determination method
IDA
retrieved
5 June 2018
stated in
The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes
GOA
curator
UniProt
UniProt protein ID
Q9Y4K3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4K3&geneProductId=UniProtKB:Q9Y4K3
determination method
IDA
retrieved
5 June 2018
stated in
Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation
GOA
curator
UniProt
UniProt protein ID
Q9Y4K3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4K3&geneProductId=UniProtKB:Q9Y4K3
determination method
IDA
retrieved
5 June 2018
stated in
Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4K3&geneProductId=UniProtKB:Q9Y4K3
determination method
EXP
retrieved
5 June 2018
stated in
Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4K3&geneProductId=UniProtKB:Q9Y4K3
determination method
EXP
ubiquitin-protein transferase activity
determination method
EXP
IBA
IDA
IEA
TAS
9 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IEA
retrieved
8 April 2019
stated in
Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation
GOA
curator
UniProt
UniProt protein ID
Q9Y4K3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IDA
retrieved
8 April 2019
stated in
The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes
GOA
curator
UniProt
UniProt protein ID
Q9Y4K3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IDA
retrieved
8 April 2019
stated in
The E3 ligase TRAF6 regulates Akt ubiquitination and activation
GOA
curator
UniProt
UniProt protein ID
Q9Y4K3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
IBA
retrieved
8 April 2019
stated in
Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
EXP
retrieved
8 April 2019
stated in
Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3
determination method
EXP
cell component
biological process
positive regulation of NF-kappaB transcription factor activity
determination method
IDA
TAS
IMP
IEA
6 references
retrieved
5 June 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4K3&geneProductId=UniProtKB:Q9Y4K3
determination method
TAS
retrieved
5 June 2018
stated in
TAK1-dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-kappaB
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4K3&geneProductId=UniProtKB:Q9Y4K3
determination method
IMP
retrieved
5 June 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4K3&geneProductId=UniProtKB:Q9Y4K3
determination method
IEA
retrieved
5 June 2018
stated in
Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling
GOA
curator
UniProt
UniProt protein ID
Q9Y4K3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4K3&geneProductId=UniProtKB:Q9Y4K3
determination method
IDA
retrieved
5 June 2018
stated in
A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains
GOA
curator
UniProt
UniProt protein ID
Q9Y4K3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4K3&geneProductId=UniProtKB:Q9Y4K3
determination method
IDA
retrieved
5 June 2018
stated in
A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4K3&geneProductId=UniProtKB:Q9Y4K3
determination method
IDA