Hyperforin (Q412742)

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chemical compound
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Language Label Description Also known as
English
Hyperforin
chemical compound

    Statements

    chemical structure
    Hyperforin-skeletal.png
    963 × 1,033; 20 KB
    0 references
    mass
    536.386560144 dalton
    1 reference
    based on heuristic
    inferred from SMILES
    canonical SMILES
    CCCC(=O)C12C(=O)C(=C(C(C1=O)(CC(C2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C
    1 reference
    stated in
    PubChem
    isomeric SMILES
    CC(C)=CCC[C@]1(C)[C@@H](CC=C(C)C)C[C@@]2(CC=C(C)C)C(=O)[C@]1(C(=O)C(C)C)C(=O)C(CC=C(C)C)=C2O
    0 references
    found in taxon
    Hypericum perforatum
    55 references
    stated in
    Current St John's wort research from mode of action to clinical efficacy
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    Treatment with Hypericum perforatum L. does not trigger decreased resistance in Staphylococcus aureus against antibiotics and Hyperforin
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    High performance liquid chromatography/electrospray mass spectrometry of Hypericum perforatum extracts
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    Identification of the major constituents of Hypericum perforatum by LC/SPE/NMR and/or LC/MS.
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    Hypericum perforatum--chemical profiling and quantitative results of St. John's Wort products by an improved high-performance liquid chromatography method
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    Improved procedure for the quality control of Hypericum perforatum L.
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    Quantitative analysis of the active components and the by-products of eight dry extracts of Hypericum perforatum L. (St John's Wort).
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    Fast high-performance liquid chromatographic analysis of naphthodianthrones and phloroglucinols from Hypericum perforatum extracts
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    Comparative evaluation of St. John's wort from different Italian regions
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    Evaluation of major active components in St. John's Wort dietary supplements by high-performance liquid chromatography with photodiode array detection and electrospray mass spectrometric confirmation
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    Identification by high-performance liquid chromatography–diode array detection–mass spectrometry and quantification by high-performance liquid chromatography–UV absorbance detection of active constituents of Hypericum perforatum
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    Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity
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    Step by step removal of hyperforin and hypericin: activity profile of different Hypericum preparations in behavioral models
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    The structure of hyperforin
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    The content of hypericins and phloroglucinols in Hypericum perforatum L. seedlings at early stage of development
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    Hypericum perforatum L. - chemotype without rutin from Italy
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    High performance liquid chromatographic analysis of St. John's wort with photodiode array detection.
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    Evaluation of chemical stability of St. John's wort commercial extract and some preparations
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    Development of a simple, rapid and reproducible HPLC assay for the simultaneous determination of hypericins and stabilized hyperforin in commercial St. John's wort preparations
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    Separation of hypericins and hyperforins in extracts of Hypericum perforatum L. using non-aqueous capillary electrophoresis with reversed electro-osmotic flow
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    Supercritical extraction of herbs I: Saw Palmetto, St John's Wort, Kava Root, and Echinacea
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    Clinical significance of hyperforin for the efficacy of Hypericum extracts on depressive disorders of different severities
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    Comparison of German St. John's wort products according to hyperforin and total hypericin content.
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    High-Performance Liquid Chromatography On-Line Coupled to High-Field NMR and Mass Spectrometry for Structure Elucidation of Constituents ofHypericum perforatumL.
    stated in
    Supercritical fluid extraction and high-performance liquid chromatographic determination of phloroglucinols in St. John's Wort (Hypericum perforatum L.).
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    Quantitative changes of dianthrones, hyperforin and flavonoids content in the flower ontogenesis of Hypericum perforatum
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    Phenolic compounds from Hypericum perforatum
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    Hypericum perforatum subspecies angustifolium shows a protective activity on the consequences of unavoidable stress exposure at lower doses than Hypericum perforatum perforatum.
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    Effect of acute drought stress and time of harvest on phytochemistry and dry weight of St. John's wort leaves and flowers
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    Significance of genetic and environmental aspects in the field cultivation of Hypericum perforatum
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    Quantitative phytochemical analyses of six hypericum species growing in slovenia
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    Adhyperforin: A Homologue of Hyperforin from Hypericum perforatum
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    Analysis and stability of Hyperici oleum
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    Hyperforin, possibly the major non-nitrogenous secondary metabolite of Hypericum perforatum L
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    Antidepressant activity of hypericum perforatum and hyperforin: the neglected possibility
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    Activity profiles of two hyperforin-containing hypericum extracts in behavioral models
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    Effects of a methanolic extract and a hyperforin-enriched CO2 extract of St. John's Wort (Hypericum perforatum) on intracerebral field potentials in the freely moving rat (Tele-Stereo-EEG).
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    Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers
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    Determination of Major Constituents in St. John's Wort Under Different Extraction Conditions
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    THE DEVELOPMENT AND EVALUATION OF AN HPLC-DAD METHOD FOR THE ANALYSIS OF THE PHENOLIC FRACTIONS FROMIN VIVOANDIN VITROBIOMASS OFHYPERICUMSPECIES
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    Determining hyperforin and hypericin content in eight brands of St. John's wort.
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    A Simple and Reliable Semipreparative High-Performance Liquid Chromatography Technique for the Isolation of Marker-Grade Hyperforin from Hypericum perforatum L. Extract
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    Simultaneous Determination of the Predominant Hyperforins and Hypericins in St. John's Wort (Hypericum perforatum L.) by Liquid Chromatography
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    Determination of St. John's Wort Components in Dietary Supplements and Functional Foods by Liquid Chromatography
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    Pharmaceutical quality of hypericum extracts
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    Isolation, purity analysis and stability of hyperforin as a standard material from Hypericum perforatum L.
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    Ontogenetic Variation Regarding Hypericin and Hyperforin Levels in Four Accessions ofHypericum perforatumL.
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    Hyperforin a constituent of St John's wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines
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    Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis.
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    Biosynthesis of hyperforin in Hypericum perforatum
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    Studies on the antioxidative activity of phloroglucinol derivatives isolated from hypericum species
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    Bisanthraquinone glycosides of Hypericum perforatum with binding inhibition to CRH-1 receptors
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    Pharmaceutical Quality of Hypericum Extracts
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    Variability in the content of the constituents of Hypericum perforatum L. and some commercial extracts
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    Investigations on the Infraspecific Variability of Hypericum perforatum L.
    Commons category
    Hyperforin
    0 references

    Identifiers

    Reaxys registry number
    6785663
    0 references
    HSDB ID
    7646
    1 reference
    stated in
    Hazardous Substances Data Bank
    HSDB ID
    7646
    publication date
    28 October 2019
    title
    HYPERFORIN (English)
    retrieved
    10 May 2021
    EC number
    601-000-9
    1 reference
    stated in
    ECHA Substance Infocard database
    ECHA Substance Infocard ID
    100.112.565
    retrieved
    27 December 2018
    title
    Bicyclo[3.3.1]non-3-ene-2,9-dione, 4-hydroxy-6-methyl-1,3,7-tris(3-methyl-2-buten-1-yl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-penten-1-yl)-, (1R,5S,6R,7S)- (English)
    quotation
    CAS no.: 11079-53-1 (English)
    ECHA Substance Infocard ID
    100.112.565
    1 reference
    stated in
    ECHA Substance Infocard database
    ECHA Substance Infocard ID
    100.112.565
    retrieved
    27 December 2018
    title
    Bicyclo[3.3.1]non-3-ene-2,9-dione, 4-hydroxy-6-methyl-1,3,7-tris(3-methyl-2-buten-1-yl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-penten-1-yl)-, (1R,5S,6R,7S)- (English)
    quotation
    CAS no.: 11079-53-1 (English)
    DrugBank ID
    DB01892
    0 references
    KNApSAcK ID
    C00034542
    0 references
    UNII
    RM741E34FP
    0 references
    NALT ID
    46555
    0 references
     
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