A vaccine targeting mutant IDH1 induces antitumour immunity. (Q48649314)

13 February 2018

title

A vaccine targeting mutant IDH1 induces antitumour immunity. (English)

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13 February 2018

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4

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Angelika B. Riemer

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Uğur Şahin

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Manuel A. Friese

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Michael Platten

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Lukas Bunse

Lukas Bunse

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Stefan Pusch

Stefan Pusch

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Stefan Eichmüller

Stefan B Eichmüller

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Wolfgang Wick

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Wolfgang Wick

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25

Andreas von Deimling

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Stefan Stevanović

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Matthias Osswald

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Matthias Osswald

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Theresa Schumacher

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Theresa Schumacher

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Iris Oezen

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Iris Oezen

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Katharina J Rauschenbach

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Katharina Rauschenbach

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Martina Ott

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Martina Ott

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Jürgen G Okun

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Jürgen Okun

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Philipp Beckhove

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Philipp Beckhove

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author name string

Benedikt Wiestler

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Jasmin Quandt

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Oliver Menn

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Melanie Keil

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Jörg Balß

12

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Agnieszka K Grabowska

14

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Isabel Vogler

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Jan Diekmann

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Nico Trautwein

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language of work or name

English

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publication date

25 June 2014

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13 February 2018

published in

Nature

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volume

512

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13 February 2018

issue

7514

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13 February 2018

page(s)

324-327

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13 February 2018

https://scigraph.springernature.com/pub.10.1038/nature13387

exact match

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cites work

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

1 reference

12 December 2020

HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis

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12 December 2020

IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas

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12 December 2020

Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

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12 December 2020

Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

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12 December 2020

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

1 reference

12 December 2020

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

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12 December 2020

Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1

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12 December 2020

An integrated genomic analysis of human glioblastoma multiforme

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12 December 2020

SYFPEITHI: database for MHC ligands and peptide motifs

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12 December 2020

Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors

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12 December 2020

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

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12 December 2020

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

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12 December 2020

Recurring mutations found by sequencing an acute myeloid leukemia genome

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12 December 2020

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

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12 December 2020

Enzymatic assay for quantitative analysis of (D)-2-hydroxyglutarate

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12 December 2020

Analysis of the IDH1 codon 132 mutation in brain tumors

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12 December 2020

Monoclonal antibody specific for IDH1 R132H mutation

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12 December 2020

Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities

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12 December 2020

IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

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12 December 2020

IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours

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12 December 2020

IDH1 and IDH2 mutations in gliomas

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12 December 2020

NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide

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12 December 2020

A mouse model of human adaptive immune functions: HLA-A2.1-/HLA-DR1-transgenic H-2 class I-/class II-knockout mice

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12 December 2020

Molecular pathology in adult gliomas: diagnostic, prognostic, and predictive markers

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12 December 2020

Accurate approximation method for prediction of class I MHC affinities for peptides of length 8, 10 and 11 using prediction tools trained on 9mers.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NATURE13387

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13 February 2018

PubMed ID

25043048

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13 February 2018