Twist family bHLH transcription factor 1 (Q575849)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

1 reference

8 April 2019

protein homodimerization activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

protein domain specific binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

DNA-binding transcription factor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

bHLH transcription factor binding

1 reference

8 April 2019

Saethre-Chotzen mutations cause TWIST protein degradation or impaired nuclear location

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

E-box binding

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

protein binding

8 references

8 April 2019

Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

Twist and p53 reciprocally regulate target genes via direct interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

In silico prediction of physical protein interactions and characterization of interactome orphans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

A "twist box" code of p53 inactivation: twist box: p53 interaction promotes p53 degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

protein heterodimerization activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

DNA-binding transcription factor activity, RNA polymerase II-specific

A census of human transcription factors: function, expression and evolution

4 references

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

Norwegian University of Science and Technology, Systems Biology team

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

ISA

8 April 2019

Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

cell component

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

HOXA5-twist interaction alters p53 homeostasis in breast cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

Saethre-Chotzen mutations cause TWIST protein degradation or impaired nuclear location

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

1 reference

8 April 2019

positive regulation of transcription regulatory region DNA binding

biological process

1 reference

8 April 2019

TWIST inactivation reduces CBFA1/RUNX2 expression and DNA binding to the osteocalcin promoter in osteoblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

embryonic skeletal system morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

positive regulation of fatty acid beta-oxidation

1 reference

8 April 2019

A possible inflammatory role of twist1 in human white adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

roof of mouth development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

positive regulation of cell motility

Twist and epithelial-mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinoma

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15672&geneProductId=UniProtKB:Q15672

1 reference

27 March 2018

negative regulation of molecular function

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

rhythmic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

1 reference

8 April 2019

positive regulation of epithelial cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

negative regulation of striated muscle tissue development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

regulation of bone mineralization

1 reference

8 April 2019

Association of TWIST1 gene polymorphisms with bone mineral density in postmenopausal women

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

negative regulation of cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

cardiac neural crest cell migration involved in outflow tract morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

cellular response to growth factor stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

positive regulation of monocyte chemotactic protein-1 production

1 reference

8 April 2019

A possible inflammatory role of twist1 in human white adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

muscle organ development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

1 reference

8 April 2019

negative regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

neuron migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

in utero embryonic development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

outer ear morphogenesis

1 reference

8 April 2019

The sonic hedgehog-patched-gli pathway in human development and disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

eyelid development in camera-type eye

1 reference

8 April 2019

Ocular phenotype correlations in patients with TWIST versus FGFR3 genetic mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

mitral valve morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

positive regulation of DNA-templated transcription, initiation

1 reference

8 April 2019

Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

negative regulation of DNA-binding transcription factor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15672&geneProductId=UniProtKB:Q15672

1 reference

27 March 2018

positive regulation of angiogenesis

1 reference

8 April 2019

Up-regulation of Twist induces angiogenesis and correlates with metastasis in hepatocellular carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

hindlimb morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

negative regulation of phosphatidylinositol 3-kinase signaling

1 reference

8 April 2019

Down-regulation of ubiquitin ligase Cbl induced by twist haploinsufficiency in Saethre-Chotzen syndrome results in increased PI3K/Akt signaling and osteoblast proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

odontogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

endocardial cushion morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

negative regulation of double-strand break repair

1 reference

8 April 2019

Role of p14ARF in TWIST-mediated senescence in prostate epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

1 reference

8 April 2019

cardiac neural crest cell development involved in outflow tract morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

neural tube closure

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

positive regulation of gene expression

1 reference

8 April 2019

Down-regulation of ubiquitin ligase Cbl induced by twist haploinsufficiency in Saethre-Chotzen syndrome results in increased PI3K/Akt signaling and osteoblast proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

negative regulation of DNA damage response, signal transduction by p53 class mediator

1 reference

8 April 2019

Role of p14ARF in TWIST-mediated senescence in prostate epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

negative regulation of skeletal muscle tissue development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

embryonic limb morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

negative regulation of oxidative phosphorylation uncoupler activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

osteoblast differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

positive regulation of tumor necrosis factor production

1 reference

8 April 2019

A possible inflammatory role of twist1 in human white adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

embryonic cranial skeleton morphogenesis

Mutations of the TWIST gene in the Saethre-Chotzen syndrome

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

Mutations in TWIST, a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

negative regulation of tumor necrosis factor production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

negative regulation of peroxisome proliferator activated receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

negative regulation of histone acetylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

embryonic camera-type eye formation

1 reference

8 April 2019

Ocular phenotype correlations in patients with TWIST versus FGFR3 genetic mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

bone development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

embryonic forelimb morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

positive regulation of transcription by RNA polymerase II

TWIST inactivation reduces CBFA1/RUNX2 expression and DNA binding to the osteocalcin promoter in osteoblasts

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

negative regulation of cellular senescence

1 reference

8 April 2019

Role of p14ARF in TWIST-mediated senescence in prostate epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

embryonic hindlimb morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

negative regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

Functional Analysis of Two Novel Mutations in TWIST1 Protein Motifs Found in Ventricular Septal Defect Patients

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

cytokine-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

1 reference

8 April 2019

http://purl.uniprot.org/uniprot/Q15672

Gene Atlas image

PBB GE TWIST1 213943 at fs.png
732 × 530; 11 KB

0 references

exact match

1 reference

Myc-type, basic helix-loop-helix (bHLH) domain

Identifiers.org

has part(s)

2 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15672

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/H7C4D7

Identifiers

MeSH descriptor ID

D051879

subject named as

Twist-Related Protein 1

0 references

MeSH tree code

D12.776.260.103.906.250

0 references

D12.776.930.125.906.250

0 references

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

20 March 2016

language of work or name

1 reference

1 reference

1 reference

0 references

Microsoft Academic ID

0 references

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

20 March 2016

language of work or name

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023