XRCC4

XRCC4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1FU1, 1IK9, 3II6, 3MUD, 3Q4F, 3RWR, 3SR2, 3W03, 4XA4, 5CHX, 5CJ0, 5CJ4, 5E50
Dynodwyr
Cyfenwau	XRCC4, SSMED, X-ray repair complementing defective repair in Chinese hamster cells 4, X-ray repair cross complementing 4, hXRCC4
Dynodwyr allanol	OMIM: 194363 HomoloGene: 2555 GeneCards: XRCC4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • ligase activity • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • identical protein binding Cydrannau o'r gell • cytosol • nucleoplasm • DNA-dependent protein kinase-DNA ligase 4 complex • DNA ligase IV complex • nonhomologous end joining complex • condensed chromosome • cnewyllyn cell Prosesau biolegol • DNA recombination • cellular response to lithium ion • cellular response to DNA damage stimulus • establishment of integrated proviral latency • DNA ligation involved in DNA repair • positive regulation of ligase activity • double-strand break repair via nonhomologous end joining • response to X-ray • double-strand break repair • GO:0100026 DNA repair Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7518	n/a
Ensembl	ENSG00000152422	n/a
UniProt	Q13426	n/a
RefSeq (mRNA)	NM_003401 NM_022406 NM_022550 NM_001318012 NM_001318013	n/a
RefSeq (protein)	NP_001304941 NP_001304942 NP_003392 NP_071801 NP_072044 NP_071801.1 NP_001304941.1 NP_001304942.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn XRCC4 yw XRCC4 a elwir hefyd yn X-ray repair complementing defective repair in Chinese hamster cells 4, isoform CRA_b (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q14.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn XRCC4.

• SSMED

Llyfryddiaeth

• "Association between single nucleotide polymorphisms of X-ray repair cross-complementing protein 4 gene and development of pancreatic cancer. ". Genet Mol Res. 2015. PMID 26345895.
• "XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency. ". J Allergy Clin Immunol. 2015. PMID 26255102.
• "Influence of XRCC4 expression in esophageal cancer cells on the response to radiotherapy. ". Med Mol Morphol. 2017. PMID 27338590.
• "Mutations in XRCC4 cause primordial dwarfism without causing immunodeficiency. ". J Hum Genet. 2016. PMID 27169690.
• "Association between insertion/deletion polymorphism in intron 3 of XRCC4 and susceptibility to type I bipolar disorder.". Psychiatr Genet. 2016. PMID 26484731.