γがんま-Endorphin

γがんま-Endorphin
Names
	Other names Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu
Identifiers
CAS Number	61512-77-4 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:80246;
ChemSpider	17294517;
KEGG	C16018;
PubChem CID	16138008;
UNII	A65G32VJ2M ;
	InChI InChI=1S/C83H131N19O27S/c1-41(2)33-55(75(120)98-65(43(5)6)79(124)100-67(45(8)106)80(125)95-57(83(128)129)34-42(3)4)94-78(123)60-20-16-31-102(60)82(127)68(46(9)107)101-72(117)52(25-27-61(86)109)91-76(121)58(39-103)96-70(115)51(19-14-15-30-84)90-71(116)53(26-28-64(112)113)92-77(122)59(40-104)97-81(126)66(44(7)105)99-73(118)54(29-32-130-10)93-74(119)56(36-47-17-12-11-13-18-47)89-63(111)38-87-62(110)37-88-69(114)50(85)35-48-21-23-49(108)24-22-48/h11-13,17-18,21-24,41-46,50-60,65-68,103-108H,14-16,19-20,25-40,84-85H2,1-10H3,(H2,86,109)(H,87,110)(H,88,114)(H,89,111)(H,90,116)(H,91,121)(H,92,122)(H,93,119)(H,94,123)(H,95,125)(H,96,115)(H,97,126)(H,98,120)(H,99,118)(H,100,124)(H,101,117)(H,112,113)(H,128,129)/t44-,45-,46-,50+,51+,52+,53+,54+,55+,56+,57+,58+,59+,60+,65+,66+,67+,68+/m1/s1 Key: GASYAMBJHBRTOE-WHDBNHDESA-N;
	SMILES C[C@H]([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)CNC(=O)CNC(=O)[C@H](CC3=CC=C(C=C3)O)N)O;
Properties
Chemical formula	C83H131N19O27S
Molar mass	1859.10434
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

γがんま-Endorphin (gamma-endorphin) is an opioid peptide that is characterized by the presence of 17 amino acids. The first 16 amino acids are identical to αあるふぁ-endorphin; leucine added at the end. In addition, γがんま-endorphin is identical to the first 17 amino acids of βべーた-endorphin. Similar to other endorphins, research focusing upon γがんま-endorphin has been ongoing since its discovery in the 1970s. Yet, most of the information about the substance's exact role within the body is speculation that has yet to be proven. Some studies have indicated, however, that the polypeptide has antipsychotic effects on a certain category of patients with schizophrenia, while others suggest that γがんま-endorphin may act to help regulate blood pressure. Further research is needed, but if γがんま-endorphin does indeed possess such characteristics, the substance could eventually be utilized as a useful means of medical treatment.^[1]

It has been hypothesized^{[by whom?]} that γがんま-endorphin may play a role in substance abuse, as well as neurological problems.^{[citation needed]} The DRD2 gene regulates dopamine^{[citation needed]} to which any mutation in this gene can lead to neurological and psychological disorders. It has been shown in a that a lack of γがんま-endorphin in utero leads to the DRD2-A2 allele over-expression. The DRD2-A1 allele increases the desire for alcohol and has been shown to be associated with a low γがんま-endorphin count.^[2] The argument of γがんま-endorphin relating to psychological issues is strong; however, more testing would need to be done to confirm this.

γがんま-Endorphin resides in the pituitary gland of humans, as well as in other animals such as rats. An experiment was performed where two human pituitary glands were made available, and through various procedures like gel filtration chromatography and high-performance chromatography, 0.7 nmol of gamma-endorphin was found.^[3]

References[edit]

^ "Molecular Expressions: Images from the Microscope". Micro.magnet.fsu.edu. Retrieved 2012-07-25.
^ Blum, Kenneth; Oscar-Berman, Marlene; Badgaiyan, Rajendra D.; Palomo, Tomas; Gold, Mark S. (May 2014). "Hypothesizing dopaminergic genetic antecedents in schizophrenia and substance seeking behavior". Medical Hypotheses. 82 (5): 606–614. doi:10.1016/j.mehy.2014.02.019. ISSN 0306-9877. PMC 4039414. PMID 24636783.
^ Burbach, J.Peter H.; Wiegant, Victor M. (1984-01-30). "Isolation and characterization of αあるふぁ-endorphin and γがんま-endorphin from single human pituitary glands". FEBS Letters. 166 (2): 267–272. doi:10.1016/0014-5793(84)80093-9. ISSN 0014-5793. PMID 6198214. S2CID 83851413.

[1] "Molecular Expressions: Images from the Microscope". Micro.magnet.fsu.edu. Retrieved 2012-07-25.

[2] Blum, Kenneth; Oscar-Berman, Marlene; Badgaiyan, Rajendra D.; Palomo, Tomas; Gold, Mark S. (May 2014). "Hypothesizing dopaminergic genetic antecedents in schizophrenia and substance seeking behavior". Medical Hypotheses. 82 (5): 606–614. doi:10.1016/j.mehy.2014.02.019. ISSN 0306-9877. PMC 4039414. PMID 24636783.

[3] Burbach, J.Peter H.; Wiegant, Victor M. (1984-01-30). "Isolation and characterization of αあるふぁ-endorphin and γがんま-endorphin from single human pituitary glands". FEBS Letters. 166 (2): 267–272. doi:10.1016/0014-5793(84)80093-9. ISSN 0014-5793. PMID 6198214. S2CID 83851413.

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