LY-2459989
Clinical data | |
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Routes of administration | Oral, intravenous |
ATC code |
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Pharmacokinetic data | |
Elimination half-life | 15 minutes (in rhesus monkeys)[1] |
Identifiers | |
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CAS Number | |
PubChem CID | |
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CompTox Dashboard (EPA) | |
Chemical and physical data | |
Formula | C23H22FN3O2 |
Molar mass | 391.446 g·mol−1 |
3D model (JSmol) | |
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LY-2459989 is a silent antagonist of the
Earlier analogues of LY-2459989 besides LY-2795050 with similar actions and potential uses have also been described.[3]
See also
References
- ^ a b c d e f Zheng MQ, Kim SJ, Holden D, Lin SF, Need A, Rash K, Barth V, Mitch C, Navarro A, Kapinos M, Maloney K, Ropchan J, Carson RE, Huang Y (2014). "An Improved Antagonist Radiotracer for the
κ -Opioid Receptor: Synthesis and Characterization of (11)C-LY2459989". J. Nucl. Med. 55 (7): 1185–91. doi:10.2967/jnumed.114.138701. PMC 4826283. PMID 24854795. - ^ Cai Z, Li S, Pracitto R, Navarro A, Shirali A, Ropchan J, Huang Y (2017). "Fluorine-18-Labeled Antagonist for PET Imaging of Kappa Opioid Receptors". ACS Chem Neurosci. 8 (1): 12–16. doi:10.1021/acschemneuro.6b00268. PMID 27741398.
- ^ Mitch CH, Quimby SJ, Diaz N, Pedregal C, de la Torre MG, Jimenez A, Shi Q, Canada EJ, Kahl SD, Statnick MA, McKinzie DL, Benesh DR, Rash KS, Barth VN (2011). "Discovery of aminobenzyloxyarylamides as
κ opioid receptor selective antagonists: application to preclinical development of aκ opioid receptor antagonist receptor occupancy tracer". J. Med. Chem. 54 (23): 8000–12. doi:10.1021/jm200789r. PMID 21958337.
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