Aromatase

Cytochrome P450, family 19, subfamily A, polypeptide 1 (Aromatase)
	Renderização PDB baseada em 3EQM.
Estruturas disponíveis
PDB	Busca de ortólogos: PDBe, RCSB
Lista de códigos PDB
	1TQA, 3EQM, 3S79, 3S7S, 4GL5, 4GL7, 4KQ8
Identificadores
Símbolos	CYP19A1; ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM
IDs externos	OMIM: 107910 MGI: 97567 HomoloGene: 30955 IUPHAR: ChEMBL: 208 GeneCards: CYP19A1 Gene
Número EC	1.14.14.14
Ontologia do gene
Função molecular	•iron ion binding; •electron carrier activity; •oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; •oxygen binding; •heme binding; •aromatase activity;
Componente celular	•endoplasmic reticulum; •endoplasmic reticulum membrane; •membrane;
Processo biológico	•steroid biosynthetic process; •estrogen biosynthetic process; •xenobiotic metabolic process; •steroid metabolic process; •androgen metabolic process; •sterol metabolic process; •small molecule metabolic process; •oxidation-reduction process; •prostate gland growth;
	Sources: Amigo / QuickGO
Padrões de expressão do ARN
	Mais dados de expressão
Ortólogos
	v; d; e;

A aromatase pertence ao grupo molecular das enzimas do citocromo p450 e age como mediador da aromatização de andrógenos em estrógenos.

Aromatase convetendo a testosterona em estradiol

Aromatase convertendo a androstenediona em estrona

Leitura de apoio

Attar E, Bulun SE (maio de 2006). «Aromatase inhibitors: the next generation of therapeutics for endometriosis?». Fertil. Steril. 85 (5): 1307–18. PMID 16647373. doi:10.1016/j.fertnstert.2005.09.064
Chen S (2004). «Aromatase and breast cancer». Front. Biosci. 3: d922–33. PMID 9696881
Strobel HW, Thompson CM, Antonovic L (2001). «Cytochromes P450 in brain: function and significance». Curr. Drug Metab. 2 (2): 199–214. PMID 11469726. doi:10.2174/1389200013338577
Simpson ER, Clyne C, Rubin G; et al. (2002). «Aromatase--a brief overview». Annu. Rev. Physiol. 64: 93–127. PMID 11826265. doi:10.1146/annurev.physiol.64.081601.142703
Bulun SE, Yang S, Fang Z; et al. (2002). «Role of aromatase in endometrial disease». J. Steroid Biochem. Mol. Biol. 79 (1-5): 19–25. PMID 11850203. doi:10.1016/S0960-0760(01)00134-0
Balthazart J, Baillien M, Ball GF (2002). «Phosphorylation processes mediate rapid changes of brain aromatase activity». J. Steroid Biochem. Mol. Biol. 79 (1-5): 261–77. PMID 11850233. doi:10.1016/S0960-0760(01)00143-1
Richards JA, Petrel TA, Brueggemeier RW (2002). «Signaling pathways regulating aromatase and cyclooxygenases in normal and malignant breast cells». J. Steroid Biochem. Mol. Biol. 80 (2): 203–12. PMID 11897504. doi:10.1016/S0960-0760(01)00187-X
Balthazart J, Baillien M, Ball GF (2002). «Interactions between aromatase (estrogen synthase) and dopamine in the control of male sexual behavior in quail». Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 132 (1): 37–55. PMID 11997208. doi:10.1016/S1096-4959(01)00531-0
Meinhardt U, Mullis PE (2002). «The aromatase cytochrome P-450 and its clinical impact». Horm. Res. 57 (5-6): 145–52. PMID 12053085. doi:10.1159/000058374
Carreau S, Bourguiba S, Lambard S; et al. (2003). «Reproductive system: aromatase and estrogens». Mol. Cell. Endocrinol. 193 (1-2): 137–43. PMID 12161013. doi:10.1016/S0303-7207(02)00107-7
Meinhardt U, Mullis PE (2003). «The essential role of the aromatase/p450arom». Semin. Reprod. Med. 20 (3): 277–84. PMID 12428207. doi:10.1055/s-2002-35374
Carreau S, Bourguiba S, Lambard S, Galeraud-Denis I (2003). «[Testicular aromatase]». J. Soc. Biol. 196 (3): 241–4. PMID 12462076
Carani C, Fabbi M, Zirilli L, Sgarbi I (2003). «[Estrogen resistance and aromatase deficiency in humans]». J. Soc. Biol. 196 (3): 245–8. PMID 12462077
Kragie L (2003). «Aromatase in primate pregnancy: a review». Endocr. Res. 28 (3): 121–8. PMID 12489562. doi:10.1081/ERC-120015041
Simpson ER (2004). «Biology of aromatase in the mammary gland». Journal of mammary gland biology and neoplasia. 5 (3): 251–8. PMID 14973387. doi:10.1023/A:1009590626450
Bulun SE, Takayama K, Suzuki T; et al. (2004). «Organization of the human aromatase p450 (CYP19) gene». Semin. Reprod. Med. 22 (1): 5–9. PMID 15083376. doi:10.1055/s-2004-823022
Simpson ER (2004). «Aromatase: biologic relevance of tissue-specific expression». Semin. Reprod. Med. 22 (1): 11–23. PMID 15083377. doi:10.1055/s-2004-823023
Bulun SE, Fang Z, Imir G; et al. (2004). «Aromatase and endometriosis». Semin. Reprod. Med. 22 (1): 45–50. PMID 15083380. doi:10.1055/s-2004-823026
Shozu M, Murakami K, Inoue M (2004). «Aromatase and leiomyoma of the uterus». Semin. Reprod. Med. 22 (1): 51–60. PMID 15083381. doi:10.1055/s-2004-823027
Chen S, Ye J, Kijima I; et al. (2005). «Positive and negative transcriptional regulation of aromatase expression in human breast cancer tissue». J. Steroid Biochem. Mol. Biol. 95 (1-5): 17–23. PMID 15955695. doi:10.1016/j.jsbmb.2005.04.002
Lambard S, Silandre D, Delalande C; et al. (2005). «Aromatase in testis: expression and role in male reproduction». J. Steroid Biochem. Mol. Biol. 95 (1-5): 63–9. PMID 16019206. doi:10.1016/j.jsbmb.2005.04.020
Bulun SE, Imir G, Utsunomiya H; et al. (2005). «Aromatase in endometriosis and uterine leiomyomata». J. Steroid Biochem. Mol. Biol. 95 (1-5): 57–62. PMID 16024248. doi:10.1016/j.jsbmb.2005.04.012
Lambard S, Carreau S (2005). «Aromatase and oestrogens in human male germ cells». Int. J. Androl. 28 (5): 254–9. PMID 16128984. doi:10.1111/j.1365-2605.2005.00546.x
Ellem SJ, Risbridger GP (2006). «Aromatase and prostate cancer». Minerva Endocrinol. 31 (1): 1–12. PMID 16498360
Brueggemeier RW, Díaz-Cruz ES (2006). «Relationship between aromatase and cyclooxygenases in breast cancer: potential for new therapeutic approaches». Minerva Endocrinol. 31 (1): 13–26. PMID 16498361
Jongen VH, Hollema H, Van Der Zee AG, Heineman MJ (2006). «Aromatase in the context of breast and endometrial cancer. A review». Minerva Endocrinol. 31 (1): 47–60. PMID 16498363
Hiltunen M, Iivonen S, Soininen H (2006). «Aromatase enzyme and Alzheimer's disease». Minerva Endocrinol. 31 (1): 61–73. PMID 16498364

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