Cardiovascular disease remains the leading cause of morbidity and mortality in the
developed world. In recent decades, extraordinary effort has been devoted to defining the …

Human aging affects the entire organism, but aging of the brain must undoubtedly be
different from that of all other organs, as neurons are highly differentiated postmitotic cells …

Hutchinson–Gilford progeria syndrome (HGPS or progeria) is typically caused by a
dominant-negative C• G-to-T• A mutation (c. 1824 C> T; p. G608G) in LMNA, the gene that …

Importance Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare fatal
premature aging disease. There is no approved treatment. Objective To evaluate the …

Hutchinson–Gilford progeria syndrome (HGPS) is a rare lethal genetic disorder
characterized by symptoms reminiscent of accelerated aging. The major underlying genetic …

Originally identified as an outcome of continuous culture of primary cells, cellular
senescence has moved beyond the culture dish and is now a bona fide driver of aging and …

LMNA encodes nuclear Lamin A/C that tethers lamina-associated domains (LADs) to the
nuclear periphery. Mutations in LMNA cause degenerative disorders including the …

Purpose To examine current evidence of the known effects of advanced paternal age on
sperm genetic and epigenetic changes and associated birth defects and diseases in …

Hutchinson–Gilford progeria syndrome (HGPS) is an extremely rare, uniformly fatal,
segmental “premature aging” disease in which children exhibit phenotypes that may give us …

Skin, as the outermost organ of the body, is constantly exposed to both intrinsic and extrinsic
causative factors of aging. Intrinsic aging is related to compromised cellular proliferative …