Amibegron
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(IUPAC) ime | |||
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Etil ([(7S)-7-([(2R)-2-(3-hlorofenil)-2-hidroksietil]amino)-5,6,7,8-tetrahidronaftalen-2-il]oksi)acetat | |||
Klinički podaci | |||
Identifikatori | |||
CAS broj | 121524-09-2 | ||
ATC kod | nije dodeljen | ||
PubChem[1][2] | 3035442 | ||
ChemSpider[3] | 108738 | ||
UNII | PDQ3ME68U3 ![]() | ||
KEGG[4] | D08851 ![]() | ||
ChEMBL[5] | CHEMBL545437 ![]() | ||
Hemijski podaci | |||
Formula | C22H26ClNO4 | ||
Mol. masa | 403,898 g/mol | ||
SMILES | eMolekuli & PubHem | ||
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Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
Amibegron (SR-58,611A) je lek koji je razvio Sanofi. On je selektivni agonist
Sanofi-Aventis je 31. jula 2008. objavio da je razvoj amibegrona prekinut.[8]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Stemmelin J, Cohen C, Terranova JP, Lopez-Grancha M, Pichat P, Bergis O, Decobert M, Santucci V, Françon D, Alonso R, Stahl SM, Keane P, Avenet P, Scatton B, le Fur G, Griebel G. Stimulation of the beta3-Adrenoceptor as a novel treatment strategy for anxiety and depressive disorders. Neuropsychopharmacology. 2008 Feb;33(3):574-87. PMID 17460614
- ↑ Overstreet DH, Stemmelin J, Griebel G. Confirmation of antidepressant potential of the selective beta3 adrenoceptor agonist amibegron in an animal model of depression. Pharmacology, Biochemistry and Behaviour. 2008 Jun;89(4):623-6. DOI:10.1016/j.pbb.2008.02.020 PMID 18358519
- ↑ Second quarter 2008 results Arhivirano 2011-08-07 na Archive.is-u. July 31, 2008, retrieved March 9, 2009.