Mitogenom-aktivirana proteinska kinaza kinaza
(Preusmjereno sa stranice MKK4)
| Mitogenom-aktivirana proteinska kinaza kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.12.2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Mitogenom-aktivirane proteinske kinaze kinaze (MAP2K) je enzim koji fosforiliše mitogenom-aktiviranu proteinsku kinazu (MAPK). MAP2K je klasifikovana kao EC 2.7.12.2.
Poznato je sedam gena:
- MAP2K1 (aka MEK1)
- MAP2K2 (aka MEK2)
- MAP2K3 (aka MKK3)
- MAP2K4 (aka MKK4}
- MAP2K5 (aka MKK5)
- MAP2K6 (aka MKK6)
- MAP2K7 (aka MKK7)
Aktivatori p38 (MKK3 i MKK6), JNK (MKK4 i MKK7), i ERK (MEK1 i MEK2) kinaza definišu nezavisne MAP kinazne puteve prenosa signala.[1][2]
- ↑ Dérijard B, et al. (1995). „Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms”. Science 267 (5198): 682–5. DOI:10.1126/science.7839144. PMID 7839144.
- ↑ Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K, Cobb MH (2001). „Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions”. Endocr. Rev. 22 (2): 153–83. DOI:10.1210/er.22.2.153. PMID 11294822.
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- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
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