Research
- Research Topics
- Cell Biology and Tumor Biology
- Stem Cells and Cancer
- Inflammatory Stress in Stem Cells
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- Advancement of clinical proteomics for systems medicine
- Bridging from the single cell to the cell population – Epo-induced cellular responses and erythroleukemia
- Deciphering tumor microenvironment interactions determining lung cancer development
- Mechanisms controlling the compensation of liver injury and towards model-based biomarkers for early detection of liver cancer
- Application of dynamic pathway modelling for personalized medicine
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Visualization of the Energy Metabolism: Oxygen-17 (17O) MR Imaging
Dynamic 17O MRI utilizes the stable and MR-detectable oxygen isotope (17O) to quantify the functional parameter of the cerebral metabolic rate of oxygen consumption (CMRO2), reflecting the energy metabolism in the human brain. The CMRO2 parameter is an indicator of cell viability. In many diseases such as Parkinson’s or in Alzheimer’s disease or cancer (‘Warburg Effect’) CMRO2 is reduced and might therefore be an important diagnostic parameter. The method, which includes inhalation of 17O2 gas, was first validated in a volunteer study, where we could verify our results and show reproducibility (Niesporek et al. Magn Reson Med 2018). Measuring various glioma patients demonstrated the capability of dynamic 17O MRI for direct metabolic imaging generating a functional contrast between healthy and malignant tissue (Paech et al. Radiology 2020). Moreover, this complex method was applied in a first patient with early subacute stroke (Ebersberger et al. Frontiers in Neuroscience 2023).
References
- Ebersberger L, Kratzer FJ, Potreck A, Niesporek SC, Keymling M, Nagel AM, ... Paech D & Platt T. First application of dynamic oxygen-17 (17O) magnetic resonance imaging at 7 Tesla in a patient with early subacute stroke. Frontiers in Neuroscience 2023.
- Paech D, Nagel AM, Schultheiss MN, Umathum R, Regnery S, Scherer M, ... & Niesporek SC. Quantitative dynamic oxygen 17 MRI at 7.0 T for the cerebral oxygen metabolism in glioma. Radiology 2020; 295(1): 181-189.
- Niesporek SC, Umathum R, Lommen JM, Behl NGR, Paech D, Bachert P, Ladd ME, Nagel AM. Reproducibility of CMRO2 determination using dynamic (17) O MRI. Magn Reson Med 2018; 79(6):2923-2934.
- Niesporek SC, Umathum R, Fiedler TM, Bachert P, Ladd ME, Nagel AM. Improved T2* determination in 23Na, 35Cl, and 17O MRI using iterative partial volume correction based on 1H MRI segmentation. Magnetic Resonance Materials in Physics, Biology and Medicine 2017:1-18.
- Niesporek SC, Hoffmann SH, Berger MC, Benkhedah N, Kujawa A, Bachert P, Nagel AM. Partial volume correction for in vivo (23)Na-MRI data of the human brain. Neuroimage 2015; 112:353-363.
- Hoffmann SH, Radbruch A, Bock M, Semmler W, Nagel AM. Direct (17)O MRI with partial volume correction: first experiences in a glioblastoma patient. MAGMA 2014; 27(6):579-587.
- Hoffmann SH, Begovatz P, Nagel AM, Umathum R, Schommer K, Bachert P, Bock M. A measurement setup for direct 17O MRI at 7 T. Magn Reson Med 2011;66(4):1109-1115.
- Nagel AM, Laun FB, Weber MA, Matthies C, Semmler W, Schad LR. Sodium MRI using a density-adapted 3D radial acquisition technique. Magn Reson Med 2009; 62(6):1565-1573.