Entry Name Viral myocarditis - Nyctereutes procyonoides (raccoon dog)
Description Myocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is still considered the dominant etiological agent. Myocarditis may be caused by direct cytopathic effects of virus, a pathologic immune response to persistent virus, or autoimmunity triggered by the viral infection. The virus enters the myocyte through internalization of the coxsackie-adenoviral receptor (CAR) and its coreceptor, decay-accelerating factor (DAF). Viral proteases cleave various proteins in the host cell. One example is viral protease 2A, which cleaves eukaryote initiation factor 4G (eIF4G) and the dystrophin protein, resulting in a complete shutdown of cap-dependent RNA translation and cytoskeletal destruction in infected cardiomyocytes, respectively. CVB3 also cleaves the member of the Bcl-2 family Bid, leading to apoptosis. CVB3 infection also induces the cleavage of cyclin D protein through a proteasome-dependent pathway, leading to the host cell-growth arrest. Viral infection and necrosis of myocytes may lead to the release of intracellular antigens, resulting in activation of self-reactive T cells. CVB infection is a significant cause of dilated cardiomyopathy (DCM) as well as myocarditis. Epidemiologically, myocarditis underlies a significant portion of patients with DCM.
Class Human Diseases; Cardiovascular diseaseBRITE hierarchy
Pathway map Ortholog table Organism Nyctereutes procyonoides (raccoon dog) [GN:
npo ]
Gene 129502319 CXADR; coxsackievirus and adenovirus receptor isoform X1 [KO:K06788 ]
129505928 CD55; complement decay-accelerating factor isoform X1 [KO:K04006 ]
129519689 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
129511656 RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860 ]
129513923 RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
129504810 EIF4G2; eukaryotic translation initiation factor 4 gamma 2 [KO:K03260 ]
129498523 EIF4G1; eukaryotic translation initiation factor 4 gamma 1 isoform X1 [KO:K03260 ]
129513383 EIF4G3; eukaryotic translation initiation factor 4 gamma 3 isoform X1 [KO:K03260 ]
129521609 CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
129512314 HLA class II histocompatibility antigen, DO beta chain [KO:K06752 ]
129512546 HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752 ]
129512547 HLA class II histocompatibility antigen, DM beta chain [KO:K06752 ]
129512797 HLA class II histocompatibility antigen, DO alpha chain [KO:K06752 ]
129512799 LOW QUALITY PROTEIN: RLA class II histocompatibility antigen, DP alpha-1 chain [KO:K06752 ]
129513026 DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752 ]
129513027 HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752 ]
129513028 SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752 ]
129513030 HLA class II histocompatibility antigen, DR alpha chain [KO:K06752 ]
129499223 class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X1 [KO:K06751 ]
129512639 DLA class I histocompatibility antigen, A9/A9 alpha chain [KO:K06751 ]
129512971 DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751 ]
129513138 DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751 ]
129513147 DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751 ]
129503626 CD80; T-lymphocyte activation antigen CD80 isoform X1 [KO:K05412 ]
129503613 CD86; LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD86 [KO:K05413 ]
Reference Authors Esfandiarei M, McManus BM
Title Molecular biology and pathogenesis of viral myocarditis.
Journal Reference Authors Badorff C, Knowlton KU
Title Dystrophin disruption in enterovirus-induced myocarditis and dilated cardiomyopathy: from bench to bedside.
Journal Reference Authors Maekawa Y, Ouzounian M, Opavsky MA, Liu PP
Title Connecting the missing link between dilated cardiomyopathy and viral myocarditis: virus, cytoskeleton, and innate immunity.
Journal Reference Authors Pankuweit S, Portig I, Maisch B
Title Pathophysiology of cardiac inflammation: molecular mechanisms.
Journal Reference Authors Gao G, Luo H
Title The ubiquitin-proteasome pathway in viral infections.
Journal Reference Authors Coyne CB, Bergelson JM
Title Virus-induced Abl and Fyn kinase signals permit coxsackievirus entry through epithelial tight junctions.
Journal Reference Authors Badorff C, Lee GH, Knowlton KU
Title Enteroviral cardiomyopathy: bad news for the dystrophin-glycoprotein complex.
Journal Reference Authors Knowlton KU
Title CVB infection and mechanisms of viral cardiomyopathy.
Journal Reference Authors Castellano G, Affuso F, Di Conza P, Fazio S
Title Myocarditis and dilated cardiomyopathy: possible connections and treatments.
Journal Reference Authors Cooper LT Jr
Title Myocarditis.
Journal Reference Authors Kawai C
Title From myocarditis to cardiomyopathy: mechanisms of inflammation and cell death: learning from the past for the future.
Journal Reference Authors Liu PP, Mason JW
Title Advances in the understanding of myocarditis.
Journal Reference Authors Mason JW
Title Myocarditis and dilated cardiomyopathy: an inflammatory link.
Journal Reference Authors Tam PE
Title Coxsackievirus myocarditis: interplay between virus and host in the pathogenesis of heart disease.
Journal Related npo04612 Antigen processing and presentation
npo04660 T cell receptor signaling pathway
KO pathway LinkDB All DBs
