(Translated by https://www.hiragana.jp/)
KEGG PATHWAY: rno05164
KEGG   PATHWAY: rno05164
Entry
rno05164                    Pathway                                
Name
Influenza A - Rattus norvegicus (rat)
Description
Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains that cause pandemics arise from avian influenza virus by genetic reassortment among influenza viruses and two surface glycoproteins HA and NA form the basis of serologically distinct virus types. The innate immune system recognizes invaded virus through multiple mechanisms. Viral non-structural NS1 protein is a multifunctional virulence factor that interfere IFN-mediated antiviral response. It inhibits IFN production by blocking activation of transcription factors such as NF-kappa B and IRF3. NS1 further inhibits the activation of IFN-induced antiviral genes. PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.
Class
Human Diseases; Infectious disease: viral
Pathway map
rno05164  Influenza A
rno05164

Organism
Rattus norvegicus (rat) [GN:rno]
Gene
29268  Tpsb2; tryptase beta-2 precursor [KO:K01340] [EC:3.4.21.59]
54271  Tpsab1; tryptase precursor [KO:K01340] [EC:3.4.21.59]
85253  Plg; plasminogen precursor [KO:K01315] [EC:3.4.21.7]
24691  Prss1; serine protease 1 precursor [KO:K01312] [EC:3.4.21.4]
25052  Prss2; anionic trypsin-2 precursor [KO:K01312] [EC:3.4.21.4]
362347  Prss3; serine protease 3 precursor [KO:K01312] [EC:3.4.21.4]
286960  1810009J06Rikl; trypsin-4 precursor [KO:K01312] [EC:3.4.21.4]
286911  Prss3b; cationic trypsin-3 precursor [KO:K01312] [EC:3.4.21.4]
683849  Prss2l1; anionic trypsin-2 [KO:K01312] [EC:3.4.21.4]
103690254  Try5; trypsin-4 isoform X1 [KO:K01312] [EC:3.4.21.4]
408247  Try10; trypsin 10 precursor [KO:K01312] [EC:3.4.21.4]
312273  Prss3bl1; trypsin V-A precursor [KO:K01312] [EC:3.4.21.4]
102554637  anionic trypsin-2 [KO:K01312] [EC:3.4.21.4]
156435  Tmprss2; transmembrane protease serine 2 [KO:K09633] [EC:3.4.21.122]
367074  Tmprss4; transmembrane protease serine 4 [KO:K09635] [EC:3.4.21.-]
64565  Tmprss11d; transmembrane protease serine 11D isoform a [KO:K09641] [EC:3.4.21.-]
25023  Prkcb; protein kinase C beta type isoform 2 [KO:K19662] [EC:2.7.11.13]
192281  Oas1a; 2'-5'-oligoadenylate synthase 1A [KO:K14216] [EC:2.7.7.84]
363938  Oas2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
494202  Oas3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
246268  Oas1b; inactive 2'-5'-oligoadenylate synthase 1B [KO:K14216] [EC:2.7.7.84]
304507  Oas1i; 2 ' -5 ' oligoadenylate synthetase 1I [KO:K14216] [EC:2.7.7.84]
359726  Rnasel; 2-5A-dependent ribonuclease [KO:K01165]
361384  Dnajb1; dnaJ homolog subfamily B member 1 [KO:K09507]
63880  Dnajc3; dnaJ homolog subfamily C member 3 precursor [KO:K09523]
54287  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
54318  Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
494338  Trim25; E3 ubiquitin/ISG15 ligase TRIM25 [KO:K10652] [EC:2.3.2.27]
287824  Trim80; tripartite motif protein 80 [KO:K10652] [EC:2.3.2.27]
297989  Rig1; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
499801  Ifih1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
315599  Nlrx1; NLR family member X1 precursor [KO:K12653]
311430  Mavs; mitochondrial antiviral-signaling protein [KO:K12648]
309361  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
84351  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
309295  Ikbkg; NF-kappa-B essential modulator [KO:K07210]
81525  Nfkbib; NF-kappa-B inhibitor beta [KO:K02581]
25493  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
81736  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580]
309165  Rela; transcription factor p65 [KO:K04735]
303479  Calcoco2; calcium-binding and coiled-coil domain-containing protein 2 [KO:K21348]
364594  Tlr3; toll-like receptor 3 precursor [KO:K05401]
363328  Ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
362788  Traf3; TNF receptor-associated factor 3 [KO:K03174]
299827  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
363984  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
292892  Irf3; interferon regulatory factor 3 [KO:K05411]
54244  Crebbp; histone lysine acetyltransferase CREBBP [KO:K04498] [EC:2.3.1.48]
170915  Ep300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
29260  Tlr4; toll-like receptor 4 precursor [KO:K10160]
317468  Tlr7; toll-like receptor 7 [KO:K05404]
301059  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
300177  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
293624  Irf7; interferon regulatory factor 7 [KO:K09447]
24493  Il1a; interleukin-1 alpha [KO:K04383]
24494  Il1b; interleukin-1 beta [KO:K04519]
24498  Il6; interleukin-6 precursor [KO:K05405]
84405  Il12a; interleukin-12 subunit alpha precursor [KO:K05406]
64546  Il12b; interleukin-12 subunit beta precursor [KO:K05425]
24835  Tnf; tumor necrosis factor [KO:K03156]
287562  Ccl12; C-C motif chemokine ligand 12 precursor [KO:K14624]
24770  Ccl2; C-C motif chemokine 2 precursor [KO:K14624]
81780  Ccl5; C-C motif chemokine 5 precursor [KO:K12499]
245920  Cxcl10; C-X-C motif chemokine 10 precursor [KO:K12671]
25464  Icam1; intercellular adhesion molecule 1 precursor [KO:K06490]
298205  Ifna4; interferon, alpha 4 precursor [KO:K05414]
298213  Ifna2; interferon alpha family, gene 2 precursor [KO:K05414]
298210  Ifna5; interferon alpha-1 precursor [KO:K05414]
690894  Ifna1; interferon alpha family, gene 5 precursor [KO:K05414]
100912314  interferon alpha-1-like [KO:K05414]
502961  Ifna4l2; similar to Interferon alpha-1 precursor [KO:K05414]
500491  Ifna16l1; interferon, alpha 16-like 1 precursor [KO:K05414]
134487075  interferon alpha-1-like [KO:K05414]
134487077  interferon alpha-1-like [KO:K05414]
100911527  Ifna4l1; interferon alpha-11-like [KO:K05414]
100912356  interferon alpha-1-like precursor [KO:K05414]
502959  Ifna1l1; similar to put. precursor MuIFN-alpha 5 precursor [KO:K05414]
24481  Ifnb1; interferon beta precursor [KO:K05415]
288264  Ifnar1; interferon alpha/beta receptor 1 isoform 1 precursor [KO:K05130]
686326  Ifnar2; interferon alpha and beta receptor subunit 2 isoform 1 precursor [KO:K05131]
84598  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
100361294  Tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
89829  Socs3; suppressor of cytokine signaling 3 [KO:K04696]
25124  Stat1; signal transducer and activator of transcription 1-alpha/beta isoform beta [KO:K11220]
288774  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
305896  Irf9; interferon regulatory factor 9 [KO:K04693]
286918  Mx2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
24575  Mx1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
81635  Adar; double-stranded RNA-specific adenosine deaminase [KO:K12968] [EC:3.5.4.37]
315713  Pml; PML nuclear body scaffold [KO:K10054] [EC:2.3.2.-]
25712  Ifng; interferon gamma precursor [KO:K04687]
116465  Ifngr1; interferon gamma receptor 1 precursor [KO:K05132]
360697  Ifngr2; interferon gamma receptor 2 precursor [KO:K05133]
24514  Jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
85483  Ciita; MHC class II transactivator isoform 2 [KO:K08060] [EC:2.7.11.1]
294274  RT1-DMa; RT1 class II, DM alpha precursor [KO:K06752]
294273  RT1-DMb; RT1 class II, DM beta precursor [KO:K06752]
24984  RT1-DOa; RT1 class II, locus DOa precursor [KO:K06752]
24986  RT1-Ha; RT1 class II, locus Ha precursor [KO:K06752]
294269  RT1-Da; RT1 class II, locus Da precursor [KO:K06752]
294270  RT1-Db1; rano class II histocompatibility antigen, D-1 beta chain precursor [KO:K06752]
309621  RT1-Ba; rano class II histocompatibility antigen, B alpha chain precursor [KO:K06752]
309622  RT1-Bb; rano class II histocompatibility antigen, B-1 beta chain precursor [KO:K06752]
365542  RT1-DOb; RT1 class II, DO beta isoform 1 [KO:K06752]
24981  RT1-Db2; RT1 class II, locus Db2 precursor [KO:K06752]
287362  Nlrp3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
282817  Pycard; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
25166  Casp1; caspase-1 [KO:K01370] [EC:3.4.22.36]
29197  Il18; interleukin-18 [KO:K05482]
361749  Il33; interleukin-33 [KO:K12967]
25513  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
60664  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
29741  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
85243  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
170911  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
366508  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
134484121  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
24185  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
25233  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
29414  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
25193  Ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
94201  Cdk4; cyclin-dependent kinase 4 isoform 1 [KO:K02089] [EC:2.7.11.22]
114483  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
246775  Tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
25385  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
246097  Fas; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
25625  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
246756  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
266610  Fadd; FAS-associated death domain protein [KO:K02373]
64044  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
64625  Bid; BH3-interacting domain death agonist [KO:K04726]
24887  Bax; apoptosis regulator BAX [KO:K02159]
367149  Bax-ps1; apoptosis regulator BAX-like [KO:K02159]
681314  apoptosis regulator BAX-like [KO:K02159]
116502  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
83529  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
25176  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
85333  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
689108  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
498885  Slc25a6; solute carrier family 25 member 6 [KO:K05863]
500871  Slc25a5l1; ADP/ATP translocase 2-like [KO:K05863]
25309  Cycs; cytochrome c, somatic [KO:K08738]
25310  Cyct; cytochrome c, testis-specific [KO:K08738]
120099910  cytochrome c, somatic-like [KO:K08738]
690675  Cycsl2; cytochrome c, somatic-like [KO:K08738]
679794  Cycsl1; cytochrome c, somatic-like [KO:K08738]
290019  Cycsl3; cytochrome c, somatic-like [KO:K08738]
78963  Apaf1; apoptotic protease-activating factor 1 [KO:K02084]
58918  Casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
25402  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
304277  Cpsf4; cleavage and polyadenylation specificity factor subunit 4 isoform 1 [KO:K14404]
100360200  Cpsf4l2; cleavage and polyadenylation specificity factor subunit 4-like [KO:K14404]
116697  Pabpn1; polyadenylate-binding protein 2 [KO:K14396]
307920  Pabpn1l; embryonic polyadenylate-binding protein 2 [KO:K14396]
59087  Nxf1; nuclear RNA export factor 1 [KO:K14284]
501621  Nxf7; nuclear RNA export factor 7 [KO:K14284]
308653  Nxf2; nuclear RNA export factor 2 isoform X1 [KO:K14284]
302591  Nxf3; nuclear RNA export factor 3 [KO:K14284]
296219  Nxt1; NTF2-related export protein 1 [KO:K14285]
315352  Nxt2; NTF2-related export protein 2 [KO:K14285]
361522  Hnrnpul1; heterogeneous nuclear ribonucleoprotein U-like protein 1 [KO:K15047]
362281  Rae1; mRNA export factor [KO:K14298]
81738  Nup98; nuclear pore complex protein Nup98-Nup96 proprotein [KO:K14297]
65190  Rsad2; S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 [KO:K15045]
83791  Fdps; farnesyl pyrophosphate synthase [KO:K00787] [EC:2.5.1.1 2.5.1.10]
102552980  Fdps-ps3; farnesyl pyrophosphate synthase-like [KO:K00787] [EC:2.5.1.1 2.5.1.10]
24680  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
24703  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
170851  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
58960  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
116590  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
50689  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100361457  Actg1l1; actin, gamma 1 propeptide-like [KO:K05692]
81822  Actb; actin, cytoplasmic 1 [KO:K05692]
287876  Actg1; actin, cytoplasmic 2 [KO:K05692]
120098222  POTE ankyrin domain family member F [KO:K05692]
81830  Rab11a; ras-related protein Rab-11A [KO:K07904]
79434  Rab11b; ras-related protein Rab-11B [KO:K07905]
85252  Xpo1; exportin-1 [KO:K14290]
288064  Kpna1; importin subunit alpha-5 [KO:K23940]
85245  Kpna2; importin subunit alpha-1 [KO:K15043]
690504  Kpna7; importin subunit alpha-8 [KO:K15043]
100359600  Kpna2l1; importin subunit alpha-1 [KO:K15043]
294392  Kpna5; importin subunit alpha-6 [KO:K15042]
362607  Kpna6; importin subunit alpha-7 [KO:K15042]
Compound
C00027  Hydrogen peroxide
C00080  H+
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:24225499
  Authors
Edinger TO, Pohl MO, Stertz S
  Title
Entry of influenza A virus: host factors and antiviral targets.
  Journal
J Gen Virol 95:263-77 (2014)
DOI:10.1099/vir.0.059477-0
Reference
PMID:19565019
  Authors
Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M
  Title
Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.
  Journal
J Mol Genet Med 3:167-75 (2008)
Reference
PMID:27751627
  Authors
Ramakrishnan B, Viswanathan K, Tharakaraman K, Dancik V, Raman R, Babcock GJ, Shriver Z, Sasisekharan R
  Title
A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.
  Journal
Trends Microbiol 24:933-943 (2016)
DOI:10.1016/j.tim.2016.09.003
Reference
PMID:18588994
  Authors
Thanh TT, van Doorn HR, de Jong MD
  Title
Human H5N1 influenza: current insight into pathogenesis.
  Journal
Int J Biochem Cell Biol 40:2671-4 (2008)
DOI:10.1016/j.biocel.2008.05.019
Reference
PMID:23977434
  Authors
Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
  Title
Influenza A induced cellular signal transduction pathways.
  Journal
J Thorac Dis 5 Suppl 2:S132-41 (2013)
DOI:10.3978/j.issn.2072-1439.2013.07.42
Reference
PMID:20020828
  Authors
Hale BG, Albrecht RA, Garcia-Sastre A
  Title
Innate immune evasion strategies of influenza viruses.
  Journal
Future Microbiol 5:23-41 (2010)
DOI:10.2217/fmb.09.108
Reference
PMID:21698289
  Authors
Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK
  Title
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
  Journal
PLoS One 6:e20215 (2011)
DOI:10.1371/journal.pone.0020215
Reference
PMID:19782761
  Authors
Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
  Title
Interplay between influenza A virus and the innate immune signaling.
  Journal
Microbes Infect 12:81-7 (2010)
DOI:10.1016/j.micinf.2009.09.007
Reference
PMID:23170167
  Authors
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
  Title
Evasion of influenza A viruses from innate and adaptive immune responses.
  Journal
Viruses 4:1438-76 (2012)
DOI:10.3390/v4091438
Reference
PMID:30487536
  Authors
Long JS, Mistry B, Haslam SM, Barclay WS
  Title
Host and viral determinants of influenza A virus species specificity.
  Journal
Nat Rev Microbiol 17:67-81 (2019)
DOI:10.1038/s41579-018-0115-z
Reference
PMID:29556226
  Authors
Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen JL
  Title
Host Immune Response to Influenza A Virus Infection.
  Journal
Front Immunol 9:320 (2018)
DOI:10.3389/fimmu.2018.00320
Reference
PMID:20130137
  Authors
Lu X, Masic A, Li Y, Shin Y, Liu Q, Zhou Y
  Title
The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1.
  Journal
J Gen Virol 91:1439-49 (2010)
DOI:10.1099/vir.0.018465-0
Reference
PMID:18980544
  Authors
Ichinohe T, Iwasaki A, Hasegawa H
  Title
Innate sensors of influenza virus: clues to developing better intranasal vaccines.
  Journal
Expert Rev Vaccines 7:1435-45 (2008)
DOI:10.1586/14760584.7.9.1435
Reference
PMID:27231932
  Authors
Le Sage V, Cinti A, Amorim R, Mouland AJ
  Title
Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
  Journal
Viruses 8:E152 (2016)
DOI:10.3390/v8060152
Reference
PMID:30510918
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
PMID:21971186
  Authors
Varga ZT, Palese P
  Title
The influenza A virus protein PB1-F2: killing two birds with one stone?
  Journal
Virulence 2:542-6 (2011)
DOI:10.4161/viru.2.6.17812
Reference
PMID:30254192
  Authors
Atkin-Smith GK, Duan M, Chen W, Poon IKH
  Title
The induction and consequences of Influenza A virus-induced cell death.
  Journal
Cell Death Dis 9:1002 (2018)
DOI:10.1038/s41419-018-1035-6
Reference
PMID:30545063
  Authors
Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML
  Title
Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.
  Journal
Viruses 10:E708 (2018)
DOI:10.3390/v10120708
Reference
PMID:21253874
  Authors
Dai X, Zhang L, Hong T
  Title
Host cellular signaling induced by influenza virus.
  Journal
Sci China Life Sci 54:68-74 (2011)
DOI:10.1007/s11427-010-4116-z
Reference
PMID:26008706
  Authors
Li J, Yu M, Zheng W, Liu W
  Title
Nucleocytoplasmic shuttling of influenza A virus proteins.
  Journal
Viruses 7:2668-82 (2015)
DOI:10.3390/v7052668
Reference
PMID:30079062
  Authors
Dou D, Revol R, Ostbye H, Wang H, Daniels R
  Title
Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
  Journal
Front Immunol 9:1581 (2018)
DOI:10.3389/fimmu.2018.01581
Reference
PMID:23236273
  Authors
Paterson D, Fodor E
  Title
Emerging roles for the influenza A virus nuclear export protein (NEP).
  Journal
PLoS Pathog 8:e1003019 (2012)
DOI:10.1371/journal.ppat.1003019
Related
pathway
rno00900  Terpenoid backbone biosynthesis
rno03013  Nucleocytoplasmic transport
rno03015  mRNA surveillance pathway
rno04010  MAPK signaling pathway
rno04110  Cell cycle
rno04144  Endocytosis
rno04210  Apoptosis
rno04620  Toll-like receptor signaling pathway
rno04621  NOD-like receptor signaling pathway
rno04622  RIG-I-like receptor signaling pathway
rno04630  JAK-STAT signaling pathway
rno05416  Viral myocarditis
KO pathway
ko05164   
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