The unfolded protein response: integrating stress signals through the stress sensor IRE1 α あるふぁ (Q24293771)

negative regulation of PERK-mediated unfolded protein response

GO:0036498

1 reference

regulation of PERK-mediated unfolded protein response

GO:1903898

1 reference

positive regulation of ATF6-mediated unfolded protein response

GO:1903897

1 reference

positive regulation of IRE1-mediated unfolded protein response

GO:1903893

1 reference

regulation of IRE1-mediated unfolded protein response

GO:1903896

1 reference

negative regulation of ATF6-mediated unfolded protein response

GO:1903894

1 reference

PERK-mediated unfolded protein response

GO:1903892

1 reference

ATF6-mediated unfolded protein response

GO:0036499

1 reference

positive regulation of PERK-mediated unfolded protein response

GO:0036500

1 reference

regulation of ATF6-mediated unfolded protein response

GO:1903899

1 reference

negative regulation of IRE1-mediated unfolded protein response

GO:1903891

1 reference

ubiquitin-dependent ERAD pathway

GO:1903895

1 reference

HLA-B27 up-regulation causes accumulation of misfolded heavy chains and correlates with the magnitude of the unfolded protein response in transgenic rats: Implications for the pathogenesis of spondylarthritis-like disease

GOA release 2020-03-11

Fabio Martinon

2

0 references

Laurie Glimcher

series ordinal

4

object named as

Laurie H Glimcher

0 references

author name string

Claudio Hetz

series ordinal

1

0 references

Diego Rodriguez

series ordinal

3

0 references

language of work or name

English

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publication date

October 2011

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published in

Physiological Reviews

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volume

91

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issue

4

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page(s)

1219-43

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cites work

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Protein folding in the ER.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Visiting the ER: the endoplasmic reticulum as a target for therapeutics in traffic related diseases

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

ER and aging-Protein folding and the ER stress response

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Attenuated BDNF-induced upregulation of GABAergic markers in neurons lacking Xbp1.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

USP14 inhibits ER-associated degradation via interaction with IRE1alpha

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Endoplasmic reticulum protein BI-1 modulates unfolded protein response signaling and protects against stroke and traumatic brain injury

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

ERAD and ERAD tuning: disposal of cargo and of ERAD regulators from the mammalian ER.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Participation of lectin chaperones and thiol oxidoreductases in protein folding within the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Signaling cell death from the endoplasmic reticulum stress response

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Protein folding stress in neurodegenerative diseases: a glimpse into the ER.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

ER stress triggers apoptosis by activating BH3-only protein Bim

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Circadian clock-coordinated 12 Hr period rhythmic activation of the IRE1alpha pathway controls lipid metabolism in mouse liver

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Targeting the endoplasmic reticulum-stress response as an anticancer strategy

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

The proteostasis boundary in misfolding diseases of membrane traffic

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Direct proteasome binding and subsequent degradation of unspliced XBP-1 prevent its intracellular aggregation

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Positive contribution of the IRE1alpha-XBP1 pathway to placental expression of CEA family genes.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Autophagy and the Integrated Stress Response

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Regulation of mRNA translation by protein folding in the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Functionality of unspliced XBP1 is required to explain evolution of overlapping reading frames

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Activation of mammalian IRE1alpha upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

ER stress in cardiovascular disease

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocon pore before and early in translocation

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Cell death: critical control points

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Plasma cell differentiation requires the transcription factor XBP-1

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Mitochondrial apoptosis induced by BH3-only molecules in the exclusive presence of endoplasmic reticular Bak

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

The unfolded protein response transducer IRE1αあるふぁ prevents ER stress-induced hepatic steatosis

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Autophagy fights disease through cellular self-digestion

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Messenger RNA targeting to endoplasmic reticulum stress signalling sites.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

The unfolded protein response signals through high-order assembly of Ire1

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

An essential role for XBP-1 in host protection against immune activation in C. elegans

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Organelle-specific initiation of cell death pathways

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Protein accumulation and neurodegeneration in the woozy mutant mouse is caused by disruption of SIL1, a cochaperone of BiP

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

The gene disrupted in Marinesco-Sjögren syndrome encodes SIL1, an HSPA5 cochaperone

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Mutations in SIL1 cause Marinesco-Sjögren syndrome, a cerebellar ataxia with cataract and myopathy

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

The role of the unfolded protein response in tumour development: friend or foe?

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

The endoplasmic reticulum stress response in immunity and autoimmunity

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Quality control in the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Signal integration in the endoplasmic reticulum unfolded protein response

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Self-eating and self-killing: crosstalk between autophagy and apoptosis

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

The BCL-2 protein family: opposing activities that mediate cell death

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

One step at a time: endoplasmic reticulum-associated degradation

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Pathogenesis of ankylosing spondylitis.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Modeling the endoplasmic reticulum unfolded protein response

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

ER stress and neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

SUMO modification regulates the transcriptional activity of XBP1

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic-leucine zipper motif is required for the unfolded protein-response pathway

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

XBP1 Controls Maturation of Gastric Zymogenic Cells by Induction of MIST1 and Expansion of the Rough Endoplasmic Reticulum

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Cytoprotective gene bi-1 is required for intrinsic protection from endoplasmic reticulum stress and ischemia-reperfusion injury

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

On the mechanism of sensing unfolded protein in the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Insulin gene mutations as a cause of permanent neonatal diabetes

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Bifunctional Apoptosis Regulator (BAR), an Endoplasmic Reticulum (ER)-associated E3 Ubiquitin Ligase, Modulates BI-1 Protein Stability and Function in ER Stress

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Central role of the scaffold protein tumor necrosis factor receptor-associated factor 2 in regulating endoplasmic reticulum stress-induced apoptosis

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Proinsulin and the genetics of diabetes mellitus

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteins

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

The transcription factor XBP-1 is essential for the development and survival of dendritic cells

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Amyotrophic lateral sclerosis pathogenesis: a journey through the secretory pathway.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

ERp57 functions as a subunit of specific complexes formed with the ER lectins calreticulin and calnexin

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Genetic evidence for a role of BiP/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Nck-dependent activation of extracellular signal-regulated kinase-1 and regulation of cell survival during endoplasmic reticulum stress

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Seipinopathy: a novel endoplasmic reticulum stress-associated disease

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Alteration of the unfolded protein response modifies neurodegeneration in a mouse model of Marinesco-Sjögren syndrome

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

The unfolded protein response in familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Regulatory roles of JNK in programmed cell death

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Identification of a consensus element recognized and cleaved by IRE1 alpha.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Endoplasmic reticulum stress: implications for inflammatory bowel disease pathogenesis

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Wolfram syndrome and WFS1 gene

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

XBP1 induces WFS1 through an endoplasmic reticulum stress response element-like motif in SH-SY5Y cells

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesis

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Adapting proteostasis for disease intervention

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

IRE1 signaling affects cell fate during the unfolded protein response

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Regulation of hepatic lipogenesis by the transcription factor XBP1

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Translational pausing ensures membrane targeting and cytoplasmic splicing of XBP1u mRNA.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

XBP-1, a novel human T-lymphotropic virus type 1 (HTLV-1) tax binding protein, activates HTLV-1 basal and tax-activated transcription

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Autophagy is activated for cell survival after endoplasmic reticulum stress

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Activating transcription factor 4 is translationally regulated by hypoxic stress

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

The mammalian unfolded protein response

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Regulation mechanisms and signaling pathways of autophagy

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

ER stress and the unfolded protein response in intestinal inflammation.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

In and Out of the ER: Protein Folding, Quality Control, Degradation, and Related Human Diseases

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Integrated endoplasmic reticulum stress responses in cancer

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

The Role of Endoplasmic Reticulum Stress in the Progression of Atherosclerosis

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

The cellular response to aggregated proteins associated with human disease

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Genome-scale approaches for discovering novel nonconventional splicing substrates of the Ire1 nuclease

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Beyond lectins: the calnexin/calreticulin chaperone system of the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Control of mitochondrial apoptosis by the Bcl-2 family

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during the mammalian unfolded protein response

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Divergent effects of PERK and IRE1 signaling on cell viability

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathway

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

IRE1αあるふぁ Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Activation of the unfolded protein response is required for defenses against bacterial pore-forming toxin in vivo.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

ER stress, hypoxia tolerance and tumor progression.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Endoplasmic reticulum stress-induced apoptosis and auto-immunity in diabetes

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

The stress rheostat: an interplay between the unfolded protein response (UPR) and autophagy in neurodegeneration

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Association of amino acid variants in the activating transcription factor 6 gene (ATF6) on 1q21-q23 with type 2 diabetes in Pima Indians

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

The inositol trisphosphate receptor in the control of autophagy

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

XBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagy

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021

Targeting XBP-1 as a novel anti-cancer strategy.

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00001.2011

7 January 2021