无机焦こげ磷酸酶

焦こげ磷酸酶（无机）2
識別しきべつ
符號ふごう	PPA2
Entrez	27068
HUGO	28883
OMIM	609988
RefSeq	NM_176869
UniProt	Q9H2U2
其他資料しりょう
基もと因いん座ざ	4 q25

焦こげ磷酸酶（无机）1
	从嗜热高温こうおん球菌きゅうきん中分なかぶん离得到いた的てき无机焦こげ磷酸酶的结构
識別しきべつ
符號ふごう	PPA1
替かえ換かわ符號ふごう	PP
Entrez	5464
HUGO	9226
OMIM	179030
RefSeq	NM_021129
UniProt	Q15181
其他資料しりょう
EC編へん號ごう	3.6.1.1
基もと因いん座ざ	10 q11.1-q24

无机焦こげ磷酸酶（英語えいご：Inorganic Pyrophosphatase，简称为焦こげ磷酸酶）是ぜ一いち种催化か一いち分子ぶんし焦こげ磷酸盐转化为两分子ぶんし磷酸盐离子的てき酶^[1]。这是一いち个高放ひ能のう的てき反はん应，因いん此此反はん应可偶联到一些热力学上不利的转化，以便驱动这些转化进行到いた完全かんぜん^[2]。此酶的てき功こう能のう乃是在ざい脂あぶら代だい谢（包括ほうかつ脂あぶら合成ごうせい与あずか降くだ解かい）、钙吸收きゅうしゅう以及骨こつ形成けいせい^[3]^[4]和かずDNA合成ごうせい^[5]中ちゅう扮ふん演えんじ重要じゅうよう角かく色しょく，其他生物せいぶつ化学かがく转化也是如此^[6]^[7]。

外部がいぶ链接

醫學いがく主題しゅだい詞し表ひょう（MeSH）：pyrophosphatases

参考さんこう文献ぶんけん

^ Harold FM. Inorganic polyphosphates in biology: structure, metabolism, and function. Bacteriol Rev. December 1966, 30 (4): 772–94. PMC 441015 . PMID 5342521.
^ Terkeltaub RA. Inorganic pyrophosphate generation and disposition in pathophysiology. Am. J. Physiol., Cell Physiol. July 2001, 281 (1): C1–C11. PMID 11401820.
^ Orimo H, Ohata M, Fujita T. Role of inorganic pyrophosphatase in the mechanism of action of parathyroid hormone and calcitonin. Endocrinology. September 1971, 89 (3): 852–8. PMID 4327778. doi:10.1210/endo-89-3-852.
^ Poole KE, Reeve J. Parathyroid hormone - a bone anabolic and catabolic agent. Curr Opin Pharmacol. December 2005, 5 (6): 612–7. PMID 16181808. doi:10.1016/j.coph.2005.07.004.
^ Nelson, David L.; Cox, Michael M. Lehninger Principles of Biochemistry, 3rd ed.. New York: Worth Publishers. 2000: 937. ISBN 1-57259-153-6.
^ Ko KM, Lee W, Yu JR, Ahnn J. PYP-1, inorganic pyrophosphatase, is required for larval development and intestinal function in C. elegans. FEBS Lett. November 2007, 581 (28): 5445–53. PMID 17981157. doi:10.1016/j.febslet.2007.10.047.
^ Usui Y, Uematsu T, Uchihashi T; et al. Inorganic polyphosphate induces osteoblastic differentiation. J. Dent. Res. May 2010, 89 (5): 504–9. PMID 20332330. doi:10.1177/0022034510363096.

[pmid5342521-1] Harold FM. Inorganic polyphosphates in biology: structure, metabolism, and function. Bacteriol Rev. December 1966, 30 (4): 772–94. PMC 441015 . PMID 5342521.

[pmid11401820-2] Terkeltaub RA. Inorganic pyrophosphate generation and disposition in pathophysiology. Am. J. Physiol., Cell Physiol. July 2001, 281 (1): C1–C11. PMID 11401820.

[pmid4327778-3] Orimo H, Ohata M, Fujita T. Role of inorganic pyrophosphatase in the mechanism of action of parathyroid hormone and calcitonin. Endocrinology. September 1971, 89 (3): 852–8. PMID 4327778. doi:10.1210/endo-89-3-852.

[pmid16181808-4] Poole KE, Reeve J. Parathyroid hormone - a bone anabolic and catabolic agent. Curr Opin Pharmacol. December 2005, 5 (6): 612–7. PMID 16181808. doi:10.1016/j.coph.2005.07.004.

[lehninger-5] Nelson, David L.; Cox, Michael M. Lehninger Principles of Biochemistry, 3rd ed.. New York: Worth Publishers. 2000: 937. ISBN 1-57259-153-6.

[pmid17981157-6] Ko KM, Lee W, Yu JR, Ahnn J. PYP-1, inorganic pyrophosphatase, is required for larval development and intestinal function in C. elegans. FEBS Lett. November 2007, 581 (28): 5445–53. PMID 17981157. doi:10.1016/j.febslet.2007.10.047.

[pmid20332330-7] Usui Y, Uematsu T, Uchihashi T; et al. Inorganic polyphosphate induces osteoblastic differentiation. J. Dent. Res. May 2010, 89 (5): 504–9. PMID 20332330. doi:10.1177/0022034510363096.

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