RBM15

RNA binding motif protein 15
RNA结合基もと序じょ蛋白たんぱく15
RNA binding motif protein 15; RNA结合基もと序じょ蛋白たんぱく15
标识
代だい号ごう	RBM15; OTT; OTT1; SPEN
扩展标识	遗传学がく：606077 鼠ねずみ基もと因いん：2443205 同どう源みなもと基はじめ因いん：23383 GeneCards: RBM15 Gene
基もと因いん本体ほんたい论描述じゅつ
分子ぶんし功こう能のう	· nucleotide binding; · protein binding; · poly(A) RNA binding;
细胞成分せいぶん	· nucleus; · nucleolus; · nuclear membrane;
生物せいぶつ过程	· patterning of blood vessels; · positive regulation of transcription of Notch receptor target; · viral process; · negative regulation of myeloid cell differentiation; · negative regulation of transcription, DNA-templated; · spleen development; · ventricular septum morphogenesis; · placenta blood vessel development;
	Sources: Amigo / QuickGO
RNA表ひょう达模式しき
	更さら多た表ひょう达数据すえ
直系ちょっけい同どう源みなもと体たい
物もの种	人ひと类
Entrez	64783
Ensembl	ENSG00000162775
UniProt	Q96T37
mRNA序列じょれつ	NM_001201545
蛋白たんぱく序列じょれつ	NP_001188474
基もと因いん位置いち	Chr 1:; 110.88 – 110.89 Mb
PubMed查询	[1]
	查; 论; 编;

假定かてい的てき的てきRNA结合蛋白たんぱく15（Putative RNA-binding protein 15）是ぜ一いち种由人じん类基もと因いん RBM15 编码的てき蛋白たんぱく质^[1]^[2]^[3] 。

参考さんこう文献ぶんけん

^ Ma Z, Morris SW, Valentine V, Li M, Herbrick JA, Cui X, Bouman D, Li Y, Mehta PK, Nizetic D, Kaneko Y, Chan GC, Chan LC, Squire J, Scherer SW, Hitzler JK. Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet. Jun 2001, 28 (3): 220–1. PMID 11431691. doi:10.1038/90054.
^ Mercher T, Coniat MB, Monni R, Mauchauffe M, Nguyen Khac F, Gressin L, Mugneret F, Leblanc T, Dastugue N, Berger R, Bernard OA. Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia. Proc Natl Acad Sci U S A. May 2001, 98 (10): 5776–9. PMC 33289 . PMID 11344311. doi:10.1073/pnas.101001498.
^ Entrez Gene: RBM15 RNA binding motif protein 15.

延伸えんしん阅读

Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Ota T, Suzuki Y, Nishikawa T; et al. Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Beausoleil SA, Jedrychowski M, Schwartz D; et al. Large-scale characterization of HeLa cell nuclear phosphoproteins.. Proc. Natl. Acad. Sci. U.S.A. 2004, 101 (33): 12130–5. PMC 514446 . PMID 15302935. doi:10.1073/pnas.0404720101.
Gerhard DS, Wagner L, Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Hsiao HH, Yang MY, Liu YC; et al. RBM15-MKL1 (OTT-MAL) fusion transcript in an adult acute myeloid leukemia patient.. Am. J. Hematol. 2005, 79 (1): 43–5. PMID 15849773. doi:10.1002/ajh.20298.
Gregory SG, Barlow KF, McLay KE; et al. The DNA sequence and biological annotation of human chromosome 1.. Nature. 2006, 441 (7091): 315–21. PMID 16710414. doi:10.1038/nature04727.
Beausoleil SA, Villén J, Gerber SA; et al. A probability-based approach for high-throughput protein phosphorylation analysis and site localization.. Nat. Biotechnol. 2006, 24 (10): 1285–92. PMID 16964243. doi:10.1038/nbt1240.
Lindtner S, Zolotukhin AS, Uranishi H; et al. RNA-binding motif protein 15 binds to the RNA transport element RTE and provides a direct link to the NXF1 export pathway.. J. Biol. Chem. 2007, 281 (48): 36915–28. PMID 17001072. doi:10.1074/jbc.M608745200.
Olsen JV, Blagoev B, Gnad F; et al. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.. Cell. 2006, 127 (3): 635–48. PMID 17081983. doi:10.1016/j.cell.2006.09.026.

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[pmid11431691-1] Ma Z, Morris SW, Valentine V, Li M, Herbrick JA, Cui X, Bouman D, Li Y, Mehta PK, Nizetic D, Kaneko Y, Chan GC, Chan LC, Squire J, Scherer SW, Hitzler JK. Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet. Jun 2001, 28 (3): 220–1. PMID 11431691. doi:10.1038/90054.

[pmid11344311-2] Mercher T, Coniat MB, Monni R, Mauchauffe M, Nguyen Khac F, Gressin L, Mugneret F, Leblanc T, Dastugue N, Berger R, Bernard OA. Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia. Proc Natl Acad Sci U S A. May 2001, 98 (10): 5776–9. PMC 33289 . PMID 11344311. doi:10.1073/pnas.101001498.

[entrez-3] Entrez Gene: RBM15 RNA binding motif protein 15.

[1]

[2]

[3]