Naloxazone
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IUPAC name
(5
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Other names
Naloxone- 6-hydrazone
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Identifiers | |
3D model (JSmol)
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ChEMBL | |
PubChem CID
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Properties | |
C19H23N3O3 | |
Molar mass | 341.40422 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Naloxazone is an irreversible
Naloxazone is the hydrazone analog of naloxone. It has been reported that naloxazone is unstable in acidic solution, dimerizing into the more stable and much more potent antagonist naloxonazine via the free NH2 of the hydrazone to form an azine linkage.[3] Under conditions in which no naloxonazine formation could be detected, naloxazone did not display irreversible
See also
[edit]- Chlornaltrexamine, an irreversible mixed agonist-antagonist
- Oxymorphazone, an irreversible
μ -opioid full agonist
References
[edit]- ^ Pasternak, G.; Childers; Snyder, S. (1980). "Opiate analgesia: Evidence for mediation by a subpopulation of opiate receptors". Science. 208 (4443): 514–6. Bibcode:1980Sci...208..514P. doi:10.1126/science.6245448. PMID 6245448.
- ^ Ling, Geoffrey S.F.; Simantov, Ronit; Clark, Janet A.; Pasternak, Gavril W. (1986). "Naloxonazine actions in vivo". European Journal of Pharmacology. 129 (1–2): 33–8. doi:10.1016/0014-2999(86)90333-X. PMID 3021478.
- ^ a b Hahn, Elliot F.; Pasternak, Gavril W. (1982). "Naloxonazine, a potent, long-lasting inhibitor of opiate binding sites". Life Sciences. 31 (12–13): 1385–8. doi:10.1016/0024-3205(82)90387-3. PMID 6292633.