Ro 3-0422
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| Names | |
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| Preferred IUPAC name
3-[(Diethoxyphosphoryl)oxy]-1-methylquinolin-1-ium methyl sulfate | |
| Other names
3-(Diethoxyphosphinyloxy)-1-methylquinolinium methylsulfate
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| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
PubChem CID
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CompTox Dashboard (EPA)
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| Properties | |
| C15H22NO8PS | |
| Molar mass | 407.37 g·mol−1 |
| Hazards | |
| Occupational safety and health (OHS/OSH): | |
Main hazards
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Extremely toxic |
| Lethal dose or concentration (LD, LC): | |
LD50 (median dose)
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20 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Ro 3-0422 is an extremely potent organophosphate acetylcholinesterase inhibitor. It is extremely toxic. The intravenous LD50 is 20
See also
[edit]References
[edit]- ^ HOBBIGER, F (June 1954). "The inhibition of cholinesterases by 3-(diethoxyphosphinyloxy)-N-methylquinolinium methylsulphate and its tertiary base". British Journal of Pharmacology and Chemotherapy. 9 (2): 159–65. doi:10.1111/j.1476-5381.1954.tb00835.x. PMC 1509437. PMID 13172424.
- ^ Andrews, K. J. M.; Atherton, F. R.; Bergel, F.; Morrison, A. L. (1954). "Hydroxypyridine and hydroxyquinoline phosphates as anti-cholinesterases". Journal of the Chemical Society (Resumed): 1638. doi:10.1039/jr9540001638.
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