EAAT2
EAAT2（excitatory amino acid transporter 2）、SLC1A2（solute carrier family 1 member 2）またはGLT-1（glutamate transporter 1）は、ヒトではSLC1A2
機能
EAAT2（SLC1A2）は、SLCファミリーの
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臨床 的 意義
EAAT2の
EAAT2のアップレギュレーションは、プレパルスインヒビションの
相互 作用
薬剤 標的 として
EAAT2は
DL-TBOA（DL-threo-
出典
- ^ a b c GRCh38: Ensembl release 89: ENSG00000110436 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005089 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
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- ^ a b c d “Entrez Gene: SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2”. 2023
年 5月 11日 閲覧 。 - ^ a b “Designing Novel Nanoformulations Targeting Glutamate Transporter Excitatory Amino Acid Transporter 2: Implications in Treating Drug Addiction”. J. Pers. Nanomed. 1 (1): 3–9. (July 2015). PMC 4666545. PMID 26635971. "The glutamate transporter 1 (GLT1)/ excitatory amino acid transporter 2 (EAAT2) is responsible for the reuptake of more than 90% glutamate in the CNS [12–14]."
- ^ Holmseth S; Scott HA; Real K; Lehre KP; Leergaard TB; Bjaalie JG; Danbolt NC (2009). “The concentrations and distributions of three C-terminal variants of the GLT1 (EAAT2; slc1a2) glutamate transporter protein in rat brain tissue suggest differential regulation”. Neuroscience 162 (4): 1055–71. doi:10.1016/j.neuroscience.2009.03.048. PMID 19328838.
- ^ “Riluzole elevates GLT-1 activity and levels in striatal astrocytes”. Neurochem. Int. 60 (1): 31–8. (2012). doi:10.1016/j.neuint.2011.10.017. PMC 3430367. PMID 22080156.
- ^ “Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes”. J. Biol. Chem. 283 (19): 13116–23. (May 2008). doi:10.1074/jbc.M707697200. PMC 2442320. PMID 18326497.
- ^ “Using glutamate homeostasis as a target for treating addictive disorders”. Behav Pharmacol 21 (5–6): 514–22. (2010). doi:10.1097/FBP.0b013e32833d41b2. PMC 2932669. PMID 20634691.
- ^ “GLT-1 upregulation impairs prepulse inhibition of the startle reflex in adult rats”. Glia 57 (7): 703–13. (2009). doi:10.1002/glia.20798. PMID 18985735.
- ^ “The mGluR2/3 agonist LY379268 blocks the effects of GLT-1 upregulation on prepulse inhibition of the startle reflex in adult rats”. Neuropsychopharmacology 35 (6): 1253–60. (2010). doi:10.1038/npp.2009.225. PMC 3055342. PMID 20072121.
- ^ “Decreased gene expression of glial and neuronal glutamate transporters after chronic antipsychotic treatment in rat brain”. Neurosci. Lett. 347 (2): 81–4. (2003). doi:10.1016/S0304-3940(03)00653-0. PMID 12873733.
- ^ “Clozapine reduces GLT-1 expression and glutamate uptake in astrocyte cultures”. Glia 50 (3): 276–9. (2005). doi:10.1002/glia.20172. PMID 15739191.
- ^ “The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba”. Mol. Cell. Neurosci. 19 (2): 152–64. (February 2002). doi:10.1006/mcne.2001.1066. PMID 11860269.
- ^ “Current approaches to enhance glutamate transporter function and expression.”. Journal of Neurochemistry 134 (6): 982–1007. (June 20, 2015). doi:10.1111/jnc.13200. PMID 26096891.
- ^ KEIKO SHIMAMOTO, BRUNO LEBRUN, YOSHIMI YASUDA-KAMATANI, MASAHIRO SAKAITANI, YASUSHI SHIGERI, NOBORU YUMOTO, and TERUMI NAKAJIMA (February 1998). “DL-threo-b-Benzyloxyaspartate, A Potent Blocker of Excitatory Amino Acid Transporters”. Molecular Pharmacology 53 (2): 195–201. doi:10.1124/mol.53.2.195. PMID 9463476.
- ^ a b c d “Potential role of N-acetylcysteine in the management of substance use disorders”. CNS Drugs 28 (2): 95–106. (2014). doi:10.1007/s40263-014-0142-x. PMC 4009342. PMID 24442756.
関連 文献
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- “Assignment of the gene SLC1A2 coding for the human glutamate transporter EAAT2 to human chromosome 11 bands p13-p12”. Cytogenet. Cell Genet. 71 (3): 212–3. (1995). doi:10.1159/000134111. PMID 7587378.
- “Molecular cloning of human brain glutamate/aspartate transporter II”. Biochim. Biophys. Acta 1191 (2): 393–6. (1994). doi:10.1016/0005-2736(94)90192-9. PMID 8172925.
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- “Large-scale concatenation cDNA sequencing”. Genome Res. 7 (4): 353–8. (1997). doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- “Expression of the glial glutamate transporter EAAT2 in the human CNS: an immunohistochemical study”. Brain Res. Mol. Brain Res. 52 (1): 17–31. (1997). doi:10.1016/S0169-328X(97)00233-7. PMID 9450673.
- “DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters”. Mol. Pharmacol. 53 (2): 195–201. (1998). doi:10.1124/mol.53.2.195. PMID 9463476.
- “Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis”. Neuron 20 (3): 589–602. (1998). doi:10.1016/S0896-6273(00)80997-6. PMID 9539131.
- “Mutations in the glutamate transporter EAAT2 gene do not cause abnormal EAAT2 transcripts in amyotrophic lateral sclerosis”. Ann. Neurol. 43 (5): 645–53. (1998). doi:10.1002/ana.410430514. PMID 9585360.
- “Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity”. J. Biol. Chem. 276 (1): 576–82. (2001). doi:10.1074/jbc.M003779200. PMID 11031254.
- “Differential RNA cleavage and polyadenylation of the glutamate transporter EAAT2 in the human brain”. Brain Res. Mol. Brain Res. 80 (2): 244–51. (2000). doi:10.1016/S0169-328X(00)00139-X. PMID 11038258.
- “Glutamate transporter EAAT2 splice variants occur not only in ALS, but also in AD and controls”. Neurology 55 (8): 1082–8. (2000). doi:10.1212/wnl.55.8.1082. PMID 11071482.
- “Intron 7 retention and exon 9 skipping EAAT2 mRNA variants are not associated with amyotrophic lateral sclerosis”. Ann. Neurol. 49 (5): 643–9. (2001). doi:10.1002/ana.1029. PMID 11357955.
- “Role of glutamate transporters in the regulation of glutathione levels in human macrophages”. Am. J. Physiol., Cell Physiol. 281 (6): C1964-70. (2001). doi:10.1152/ajpcell.2001.281.6.C1964. PMID 11698255.
- “Role of glial glutamate transporters in the facilitatory action of FK960 on hippocampal neurotransmission”. Brain Res. Mol. Brain Res. 97 (1): 7–12. (2001). doi:10.1016/S0169-328X(01)00304-7. PMID 11744157.
- “Benzodiazepines differently modulate EAAT1/GLAST and EAAT2/GLT1 glutamate transporters expressed in CHO cells”. Neurochem. Int. 40 (4): 321–6. (2002). doi:10.1016/S0197-0186(01)00087-0. PMID 11792462.
- “The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba”. Mol. Cell. Neurosci. 19 (2): 152–64. (2002). doi:10.1006/mcne.2001.1066. PMID 11860269.
- “Distribution of two splice variants of the glutamate transporter GLT1 in the retinas of humans, monkeys, rabbits, rats, cats, and chickens”. J. Comp. Neurol. 445 (1): 1–12. (2002). doi:10.1002/cne.10095. PMID 11891650.