NXF1
| NXF1 | |||||||||||||||||||||||||
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| NXF1, MEX67, TAP, nuclear RNA export factor 1 | |||||||||||||||||||||||||
| OMIM: 602647 MGI: 1858330 HomoloGene: 38176 GeneCards: NXF1 | |||||||||||||||||||||||||
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| オルソログ | |||||||||||||||||||||||||
| ヒト | マウス | ||||||||||||||||||||||||
| Entrez | |||||||||||||||||||||||||
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| RefSeq (mRNA) | |||||||||||||||||||||||||
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(UCSC) | Chr 11: 62.79 – 62.81 Mb | Chr 11: 8.73 – 8.75 Mb | |||||||||||||||||||||||
| PubMed | [3] | [4] | |||||||||||||||||||||||
| ウィキデータ | |||||||||||||||||||||||||
NXF1（nuclear RNA export factor 1）は、ヒトではNXF1
機能
[| TAP_C | |||||||||
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 complex between tap uba domain and fxfg nucleoporin peptide | |||||||||
| TAP_C | |||||||||
| Pfam | PF03943 | ||||||||
| Pfam clan | CL0214 | ||||||||
| InterPro | IPR005637 | ||||||||
| SCOP | 1go5 | ||||||||
| SUPERFAMILY | 1go5 | ||||||||
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NXF1は
相互 作用
[NXF1は、TNPO2[13]、MAGOH[14]、U2AF1[15]、DHX9[16]、HuD[17]、NUP214[18][19]と
出典
[- ^ a b c GRCh38: Ensembl release 89: ENSG00000162231 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000010097 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Tap: a novel cellular protein that interacts with tip of herpesvirus saimiri and induces lymphocyte aggregation”. Immunity 6 (5): 571–82. (May 1997). doi:10.1016/S1074-7613(00)80345-3. PMID 9175835.
- ^ a b “TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus”. Molecular Cell 1 (5): 649–59. (April 1998). doi:10.1016/S1097-2765(00)80065-9. PMID 9660949.
- ^ “The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human”. The EMBO Journal 18 (9): 2593–609. (May 1999). doi:10.1093/emboj/18.9.2593. PMC 1171339. PMID 10228171.
- ^ a b “Structure of the C-terminal FG-nucleoporin binding domain of Tap/NXF1”. Nature Structural Biology 9 (4): 247–51. (April 2002). doi:10.1038/nsb773. PMID 11875519.
- ^ a b “Prediction of structural domains of TAP reveals details of its interaction with p15 and nucleoporins”. EMBO Reports 1 (1): 53–8. (July 2000). doi:10.1093/embo-reports/kvd009. PMC 1083685. PMID 11256625.
- ^ “Entrez Gene: NXF1 nuclear RNA export factor 1”. 2020
年 12月 20日 閲覧 。 - ^ “A natural allele of Nxf1 suppresses retrovirus insertional mutations”. Nature Genetics 35 (3): 221–8. (November 2003). doi:10.1038/ng1247. PMC 2756099. PMID 14517553.
- ^ “Multipotent genetic suppression of retrotransposon-induced mutations by Nxf1 through fine-tuning of alternative splicing”. PLOS Genetics 5 (5): e1000484. (May 2009). doi:10.1371/journal.pgen.1000484. PMC 2674570. PMID 19436707.
- ^ “Karyopherin beta 2B participates in mRNA export from the nucleus”. Proceedings of the National Academy of Sciences of the United States of America 99 (22): 14195–9. (October 2002). Bibcode: 2002PNAS...9914195S. doi:10.1073/pnas.212518199. PMC 137860. PMID 12384575.
- ^ “Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex”. The EMBO Journal 20 (22): 6424–33. (November 2001). doi:10.1093/emboj/20.22.6424. PMC 125744. PMID 11707413.
- ^ “U2AF participates in the binding of TAP (NXF1) to mRNA”. The Journal of Biological Chemistry 277 (6): 3935–42. (February 2002). doi:10.1074/jbc.M107598200. PMID 11724776.
- ^ “Specific interaction between RNA helicase A and Tap, two cellular proteins that bind to the constitutive transport element of type D retrovirus”. The Journal of Biological Chemistry 275 (42): 32694–700. (October 2000). doi:10.1074/jbc.M003933200. PMID 10924507.
- ^ “TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD”. Biochemical and Biophysical Research Communications 321 (2): 291–7. (August 2004). doi:10.1016/j.bbrc.2004.06.140. PMID 15358174.
- ^ “TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture”. Molecular and Cellular Biology 20 (23): 8996–9008. (December 2000). doi:10.1128/MCB.20.23.8996-9008.2000. PMC 86553. PMID 11073998.
- ^ “In vitro analysis of nuclear transport mediated by the C-terminal shuttle domain of Tap”. The Journal of Biological Chemistry 276 (45): 42355–63. (November 2001). doi:10.1074/jbc.M103916200. PMID 11551912.
外部 リンク
[- PDBe-KB - ヒトNXF1に
関 してPDBで利用 可能 な全 構造 の概要