Eikozanoidni receptor

Eikozanoidni receptor je integralni membranski protein koji detektuje prisustvo eikozanoidnih signalnih molekula. Većina, mada ne svi, su G protein spregnuti receptori. Primer ne-GPCR receptora koji vezuje eikozanoide je PPAR-γがんま.^[1]

Ovo su poznati humani eikozanoidni GPCR receptori grupisani po tipu eikozanoidnog liganda koji vezuju:^[2]^[3]

Leukotrien

PGD₂: DP-(PGD₂)
- DP₁ (Prostaglandin D2 receptor) - PTGDR
- DP₂ (GPR44) - GPR44
PGE₂:
- EP₁-(PGE₂) (PTGER1) - PTGER1
- EP₂-(PGE₂) (PTGER2) - PTGER2
- EP₃-(PGE₂) (PTGER3) - PTGER3
- EP₄-(PGE₂) (PTGER4) - PTGER4
PGF_{2αあるふぁ}: FP-(PGF_{2αあるふぁ}) (PTGFR) - PTGFR
PGI₂ (prostaciklin): IP-(PGI₂) (PTGIR) - PTGIR
TXA₂ (tromboksan): TP-(TXA₂) (TBXA2R) - TBXA2R

^ DuBois RN, Gupta R, Brockman J, Reddy BS, Krakow SL, Lazar MA (1998). „The nuclear eicosanoid receptor, PPAR-γがんま, is aberrantly expressed in colonic cancers”. Carcinogenesis. 19 (1): 49—53. PMID 9472692. doi:10.1093/carcin/19.1.49.
^ Coleman RA, Smith WL, Narumiya S (1994). „International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes”. Pharmacol. Rev. 46 (2): 205—29. PMID 7938166.
^ Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Nicosia S, Serhan CN, Shimizu T, Yokomizo T (2003). „International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors”. Pharmacol. Rev. 55 (1): 195—227. PMID 12615958. doi:10.1124/pr.55.1.8.
^ Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Rovati GE, Serhan CN, Shimizu T, Yokomizo T (2004). „International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor”. Pharmacol. Rev. 56 (1): 149—57. PMID 15001665. doi:10.1124/pr.56.1.4.

„Leukotriene Receptors”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.
„Prostanoid Receptors”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 15. 04. 2021. г.
Eicosanoid+receptors на US National Library of Medicine Medical Subject Headings (MeSH)