维基百科,自由的百科全书
依米妥珠单抗[註 1](INN:Emibetuzumab[1];开发代号:LY2875358)是一种人源化单克隆抗体,设计用于治疗癌症。[2]目前正处于针对非小细胞肺癌患者的II期试验中。[3]
该药物由礼来公司开发。
- ^ World Health Organization. International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 111 (PDF). WHO Drug Information. 2014, 28 (2) [2024-03-12]. (原始内容存档 (PDF)于2020-08-15).
- ^ Statement On A Nonproprietary Name Adopted By The USAN Council - Emibetuzumab, American Medical Association.
- ^ Camidge DR, Moran T, Demedts I, Grosch H, Di Mercurio JP, Mileham KF, et al. A randomized, open-label, phase 2 study of emibetuzumab plus erlotinib (LY+E) and emibetuzumab monotherapy (LY) in patients with acquired resistance to erlotinib and MET diagnostic positive (MET Dx+) metastatic NSCLC.. [2024-03-12]. (原始内容存档于2017-03-29).
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| 血管生成素 | |
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| CNTF | |
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| EGF(ErbB)
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| FGF | FGFR1 | |
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| FGFR2 |
- 受體激動劑:Ersofermin
- FGF (1, 2 (bFGF), 3, 4, 5, 6, 7 (KGF), 8, 9, 10 (KGF2), 17, 18, 22)
- Palifermin
- Repifermin
- Sprifermin
- Trafermin
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| FGFR3 | |
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| FGFR4 | |
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| Unsorted | |
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| HGF (c-Met) | |
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| IGF | |
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| LNGF (p75NTR) | |
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| PDGF | |
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| RET (GFL) | |
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| SCF (c-Kit) | |
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| TGFβ | |
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| Trk | TrkA |
- Negative allosteric modulators: VM-902A
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| TrkB |
- 受體激動劑:3,7-DHF
- 3,7,8,2'-THF
- 4'-DMA-7,8-DHF
- 7,3'-DHF
- 7,8-DHF
- 7,8,2'-THF
- 7,8,3'-THF
- 阿米替林
- BDNF
- BNN-20
- Deoxygedunin
- Deprenyl
- Diosmetin
- DMAQ-B1
- HIOC
- LM22A-4
- N-乙酰血清素
- NT-3
- NT-4
- Norwogonin (5,7,8-THF)
- R7
- TDP6
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| TrkC | |
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| VEGF | |
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| 其他 |
- Additional growth factors: Adrenomedullin
- Colony-stimulating factors (see here instead)
- Connective tissue growth factor (CTGF)
- Ephrins (A1, A2, A3, A4, A5, B1, B2, B3)
- 紅血球生成素 (see here instead)
- 葡萄糖-6-磷酸異構酶(GPI; PGI, PHI, AMF)
- Glia maturation factor (GMF)
- Hepatoma-derived growth factor (HDGF)
- 白细胞介素/T-cell growth factors (see here instead)
- 白血病抑制因子(LIF)
- Macrophage-stimulating protein (MSP; HLP, HGFLP)
- Midkine (NEGF2)
- Migration-stimulating factor (MSF; PRG4)
- Oncomodulin
- Pituitary adenylate cyclase-activating peptide (PACAP)
- Pleiotrophin
- Renalase
- 促血小板生成素 (see here instead)
- Wnt信号通路
- Additional growth factor receptor modulators: Cerebrolysin (neurotrophin mixture)
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