维基百科,自由的百科全书
昂妥昔珠单抗(INN:Ontuxizumab[1])是一种人源化兔单克隆抗体,[2]设计用于治疗癌症。它与内皮唾液酸蛋白(也称TEM1或CD248)结合。[3]该药物的I期试验已经完成,该药物被美国食品药品监督管理局授予治疗肉瘤的孤儿药地位。目前正处于黑色素瘤、结直肠癌、肉瘤和淋巴瘤的II期试验中。[4]
该药物由Morphotek和路德维希癌症研究所开发。[4]
- ^ World Health Organization. International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 109 (PDF). WHO Drug Information. 2013, 27 (2) [2024-01-23]. (原始内容存档 (PDF)于2022-01-20).
- ^ US 20100260769,Sass PM, Kline B, Nicolaides N, Grasso L, Harley S,「Endosialin binding molecules」,发表于2010-04-08,指定于Morphotek Inc
- ^ Kiyohara E, Donovan N, Takeshima L, Huang S, Wilmott JS, Scolyer RA, et al. Endosialin Expression in Metastatic Melanoma Tumor Microenvironment Vasculature: Potential Therapeutic Implications. Cancer Microenvironment. August 2015, 8 (2): 111–8. PMC 4542822
. PMID 26085332. doi:10.1007/s12307-015-0168-8.
- ^ 4.0 4.1 Ontuxizumab. Adis Insight. Springer Nature Switzerland AG. [2024-01-23]. (原始内容存档于2024-01-23).