氟-18
![]() 氟-18 | |
18F | |
氟-18、F-18、氟-18 | |
9 | |
9 | |
CAS | 13981-56-1 ![]() |
109.771(20) min | |
18O | |
18.0009380(6) u | |
1+ | |
过剩 | 873.431± 0.593 keV |
结合 | 137369.199± 0.593 keV |
0.6335 | |
电子 | 1.6555 |
氟的 |
氟-18(18F)
氟-18
制 备
[编辑]氟-18
水溶液 製 備
[编辑]氣體 製 備
[编辑]另一種合成方法是以含有氧-18
化学 性 质
[编辑]应用
[编辑]氟-18
氟化钠於1972
氟代
此外,
参考 资料
[编辑]- ^ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Volterrani, Duccio; Erba, Paola Anna; Carrió, Ignasi; William Strauss, H.; Mariani, Giuliano. Nuclear Medicine Textbook: Methodology and Clinical Applications. 10 August 2019. ISBN 978-3-319-95564-3.
- ^ Fowler J. S. and Wolf A. P. (1982) The synthesis of carbon-11, fluorine-18 and nitrogen-13 labeled radiotracers for biomedical applications. Nucl. Sci. Ser. Natl Acad. Sci. Natl Res. Council Monogr. 1982.
- ^ Casella, V., Ido, T., Wolf, A. P., Fowler, J. S., MacGegor, R. R., & Ruth, T. J. Anhydrous F-18 labeled elemental fluorine for radiopharmaceutical preparation (PDF). Journal of Nuclear Medicine. 1980, (21): 750–757 [2020-10-08].
- ^ Lagunas-Solar, Manuel C.; Carvacho, Omar F. Cyclotron production of PET radionuclides: No-carrier-added fluorine-18 with high-energy protons on natural neon gas targets. Applied Radiation and Isotopes. 1995, 46 (9): 833–838. doi:10.1016/0969-8043(95)00148-7.
- ^ Chirakal, R.; Adams, R.M.; Firnau, G.; Schrobilgen, G.J.; Coates, G.; Garnett, E.S. Electrophilic 18F from a siemens 11 MeV proton-only cyclotron. Nuclear Medicine and Biology. 1995, 22 (1): 111–116. PMID 7735160. doi:10.1016/0969-8051(94)E0064-P.
- ^ Guillaume, Marcel; Luxen, Andre; Nebeling, Bruno; Argentini, Mario; Clark, John C.; Pike, Victor W. Recommendations for fluorine-18 production. International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes. 1991, 42 (8): 749–762. doi:10.1016/0883-2889(91)90179-5.
- ^ Mettler, Fred A.; Guiberteau, Milton J. Essentials of Nuclear Medicine and Molecular Imaging E-Book. 17 August 2018. ISBN 9780323567893.
- ^ Blau, Monte; Ganatra, Ramanik; Bender, Merrill A. 18F-fluoride for bone imaging. Seminars in Nuclear Medicine. January 1972, 2 (1): 31–37. doi:10.1016/S0001-2998(72)80005-9.
- ^ Ordonez, A. A.; DeMarco, V. P.; Klunk, M. H.; Pokkali, S.; Jain, S.K. Imaging Chronic Tuberculous Lesions Using Sodium [18F]Fluoride Positron Emission Tomography in Mice.. Molecular Imaging and Biology. October 2015, 17 (5): 609–614. PMC 4561601
. PMID 25750032. doi:10.1007/s11307-015-0836-6.
- ^ Yen, Ruoh-Fang; Chen, Chih-Yu; Cheng, Mei-Fang; Wu, Yen-Wen; Shiau, Yu-Chien; Wu, Karl; Hong, Ruey-Long; Yu, Chong-Jen; Wang, Kao-Lun; Yang, Rong-Sen. The diagnostic and prognostic effectiveness of F-18 sodium fluoride PET-CT in detecting bone metastases for hepatocellular carcinoma patients. Nuclear Medicine Communications. 2010, 31 (7): 637–645. PMID 20389259. doi:10.1097/MNM.0b013e3283399120.
- ^ Som, P.; Atkins, H. L.; Bandoypadhyay, D.; Fowler, J. S.; MacGregor, R. R.; Matsui, K.; Oster, Z. H.; Sacker, D. F.; Shiue, C. Y.; Turner, H.; Wan, C. N.; Wolf, A. P.; Zabinski, S. V. A fluorinated glucose analog, 2-fluoro-2-deoxy-D-glucose (F-18): Nontoxic tracer for rapid tumor detection. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 1980, 21 (7): 670–5. PMID 7391842.
- ^ Kubota, Kazuo. From tumor biology to clinical PET: A review of positron emission tomography (PET) in oncology. Annals of Nuclear Medicine. 2001, 15 (6): 471–486. PMID 11831394. doi:10.1007/BF02988499.
- ^ Grech-Sollars, Matthew; Ordidge, Katherine L.; Vaqas, Babar; Davies, Claire; Vaja, Vijay; Honeyfield, Lesley; Camp, Sophie; Towey, David; Mayers, Helen; Peterson, David; o'Neill, Kevin; Roncaroli, Federico; Barwick, Tara D.; Waldman, Adam D. Imaging and Tissue Biomarkers of Choline Metabolism in Diffuse Adult Glioma: 18F-Fluoromethylcholine PET/CT, Magnetic Resonance Spectroscopy, and Choline Kinase
α . Cancers. 2019, 11 (12): 1969. PMC 6966628. PMID 31817833. doi:10.3390/cancers11121969.
- ^ Hara, T.; Kosaka, N.; Kishi, H. Development of (18)F-fluoroethylcholine for cancer imaging with PET: Synthesis, biochemistry, and prostate cancer imaging. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 2002, 43 (2): 187–99. PMID 11850483.
- ^ Lapa, C.; Linsenmann, T.; Monoranu, C. M.; Samnick, S.; Buck, A. K.; Bluemel, C.; Czernin, J.; Kessler, A. F.; Homola, G. A.; Ernestus, R.-I.; Lohr, M.; Herrmann, K. Comparison of the Amino Acid Tracers 18F-FET and 18F-DOPA in High-Grade Glioma Patients. Journal of Nuclear Medicine. 2014, 55 (10): 1611–1616. PMID 25125481. doi:10.2967/jnumed.114.140608.
- ^ Shields, A. F. PET imaging with 18F-FLT and thymidine analogs: Promise and pitfalls. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 2003, 44 (9): 1432–4. PMID 12960188.
- ^ Guo, Hua; Harikrishna, Kommidi; Vedvyas, Yogindra; McCloskey, Jaclyn E; Zhang, Weiqi; Chen, Nandi; Nurili, Fuad; Wu, Amy P; Sayman, Haluk B. A fluorescent, [ 18 F]-positron-emitting agent for imaging PMSA allows genetic reporting in adoptively-transferred, genetically-modified cells. ACS Chemical Biology. 2019-05-23, 14: 1449–1459. ISSN 1554-8929. PMC 6775626
. PMID 31120734. doi:10.1021/acschembio.9b00160 (
英 语). - ^ Vandenberghe, Rik; Van Laere, Koen; Ivanoiu, Adrian; Salmon, Eric; Bastin, Christine; Triau, Eric; Hasselbalch, Steen; Law, Ian; Andersen, Allan; Korner, Alex; Minthon, Lennart; Garraux, Gaëtan; Nelissen, Natalie; Bormans, Guy; Buckley, Chris; Owenius, Rikard; Thurfjell, Lennart; Farrar, Gill; Brooks, David J. 18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: A phase 2 trial. Annals of Neurology. 2010, 68 (3): 319–329. PMID 20687209. doi:10.1002/ana.22068.
- ^ Hendrickson, Kristi; Phillips, Mark; Smith, Wade; Peterson, Lanell; Krohn, Kenneth; Rajendran, Joseph. Hypoxia imaging with [F-18] FMISO-PET in head and neck cancer: Potential for guiding intensity modulated radiation therapy in overcoming hypoxia-induced treatment resistance. Radiotherapy and Oncology. 2011, 101 (3): 369–375. PMC 3225491
. PMID 21872957. doi:10.1016/j.radonc.2011.07.029.
- ^ Rodriguez, Erik A.; Wang, Ye; Crisp, Jessica L.; Vera, David R.; Tsien, Roger Y.; Ting, Richard. New Dioxaborolane Chemistry Enables [18F]-Positron-Emitting, Fluorescent [18F]-Multimodality Biomolecule Generation from the Solid Phase. Bioconjugate Chemistry. 2016-04-27, 27 (5): 1390–1399. PMC 4916912
. PMID 27064381. doi:10.1021/acs.bioconjchem.6b00164 (
英 语).
氟-17 |
氟-18 氟 |
氟-19 |
氖-18 |
氟-18 |
氧-18 |