MASP-1

Mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
有效ゆうこう结构
PDB	直系ちょっけい同どう源みなもと检索：PDBe, RCSB
PDB查询代だい码列表ひょう
	3DEM, 3GOV, 4AQB, 4DJZ, 4IGD, 4IW4, 4KKD
标识
代だい号ごう	MASP1; 3MC1; CRARF; CRARF1; MAP1; MASP; MASP3; MAp44; PRSS5; RaRF
扩展标识	遗传学がく：600521 同どう源みなもと基はじめ因いん：89143 GeneCards: MASP1 Gene
EC編へん號ごう	3.4.21.-
基もと因いん本体ほんたい论描述じゅつ
分子ぶんし功こう能のう	· serine-type endopeptidase activity; · calcium ion binding; · protein binding; · peptidase activity; · protein homodimerization activity; · calcium-dependent protein binding;
细胞成分せいぶん	· extracellular region; · extracellular space;
生物せいぶつ过程	· complement activation, lectin pathway; · proteolysis; · receptor-mediated endocytosis; · complement activation; · innate immune response; · negative regulation of complement activation;
	Sources: Amigo / QuickGO
直系ちょっけい同どう源みなもと体たい
	查; 论; 编;

甘露かんろ糖とう结合凝集ぎょうしゅう素もと丝氨酸さん蛋白たんぱく酶1 （Mannan-binding lectin serine protease 1，也被称しょう为 甘露かんろ糖とう相しょう关丝氨酸蛋白たんぱく酶1，mannose-associated serine protease 1，缩写MASP-1）是ぜ由人よしと类基もと因いん MASP1 编码的てき一いち种酶。^[1]^[2]^[3]

MASP-1参与さんよ补体系けい统的てき凝集ぎょうしゅう素もと途と径みち，负责的てき切きり割わりC4和わC2形成けいせいC4b2a，作さく为C3-转化酶参与さんよ下か一いち步ほ的てき反はん应。^[4]

另见

甘露かんろ聚糖结合凝集ぎょうしゅう素もと

参考さんこう文献ぶんけん

^ A new member of the C1s family of complement proteins found in a bactericidal factor, Ra-reactive factor, in human serum. Biochemical and Biophysical Research Communications. Oct 1993, 196 (2): 1003–9. PMID 8240317. doi:10.1006/bbrc.1993.2349.
^ Molecular characterization of a novel serine protease involved in activation of the complement system by mannose-binding protein. International Immunology. Apr 1994, 6 (4): 665–9. PMID 8018603. doi:10.1093/intimm/6.4.665.
^ Entrez Gene: mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor).
^ Proteolytic activities of two types of mannose-binding lectin-associated serine protease. Journal of Immunology. Sep 2000, 165 (5): 2637–42 [2016-11-24]. PMID 10946292. doi:10.4049/jimmunol.165.5.2637. （原始げんし内容ないよう存そん档于2009-01-09）.

外部がいぶ链接

醫學いがく主題しゅだい詞し表ひょう（MeSH）：MASP+Proteases

MASP-1引用いんよう了りょう美国びくに国家こっか医学いがく图书馆提供ていきょう的てき資料しりょう，这些資料しりょう属ぞく于公共こうきょう领域。

[pmid8240317-1] A new member of the C1s family of complement proteins found in a bactericidal factor, Ra-reactive factor, in human serum. Biochemical and Biophysical Research Communications. Oct 1993, 196 (2): 1003–9. PMID 8240317. doi:10.1006/bbrc.1993.2349.

[pmid8018603-2] Molecular characterization of a novel serine protease involved in activation of the complement system by mannose-binding protein. International Immunology. Apr 1994, 6 (4): 665–9. PMID 8018603. doi:10.1093/intimm/6.4.665.

[entrez-3] Entrez Gene: mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor).

[pmid10946292-4] Proteolytic activities of two types of mannose-binding lectin-associated serine protease. Journal of Immunology. Sep 2000, 165 (5): 2637–42 [2016-11-24]. PMID 10946292. doi:10.4049/jimmunol.165.5.2637. （原始げんし内容ないよう存そん档于2009-01-09）.

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