サイクリンF
CCNF | |||||||||||||||||||||||||
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CCNF, FBX1, FBXO1, cyclin F, FTDALS5 | |||||||||||||||||||||||||
OMIM: 600227 MGI: 102551 HomoloGene: 1335 GeneCards: CCNF | |||||||||||||||||||||||||
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オルソログ | |||||||||||||||||||||||||
ヒト | マウス | ||||||||||||||||||||||||
Entrez | |||||||||||||||||||||||||
Ensembl | |||||||||||||||||||||||||
UniProt | |||||||||||||||||||||||||
RefSeq (mRNA) | |||||||||||||||||||||||||
RefSeq ( | |||||||||||||||||||||||||
(UCSC) | Chr 16: 2.43 – 2.46 Mb | Chr 16: 24.44 – 24.47 Mb | |||||||||||||||||||||||
PubMed | [3] | [4] | |||||||||||||||||||||||
ウィキデータ | |||||||||||||||||||||||||
サイクリンF(
機能
[サイクリンFはサイクリンファミリーのメンバーである。サイクリンはサイクリン
発見 と特性
[CCNF
発現 パターン
[サイクリンFのmRNAはヒトの
役割
[サイクリンFは、
RRM2
[RRM2はリボヌクレオチドレダクターゼであり、リボヌクレオチドからデオキシリボヌクレオチドへの
CP110
[NuSAP
[NuSAPはサイクリンFの
SLBP
[SLBPは
E2F
[E2F1、E2F2、E2F3aは、E2Fファミリー
臨床 的 意義
[神経 変性 疾患
[CCNF
がん
[サイクリンFの
出典
[- ^ a b c GRCh38: Ensembl release 89: ENSG00000162063 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000072082 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “A novel cyclin gene (CCNF) in the region of the polycystic kidney disease gene (PKD1)”. Genomics 24 (1): 27–33. (November 1994). doi:10.1006/geno.1994.1578. PMID 7896286.
- ^ a b “Entrez Gene: CCNF cyclin F”. 2024
年 7月 14日 閲覧 。 - ^ a b c d e f g h i “Human cyclin F”. The EMBO Journal 13 (24): 6087–98. (December 1994). doi:10.1002/j.1460-2075.1994.tb06955.x. PMC 395587. PMID 7813445 .
- ^ “A novel cyclin gene (CCNF) in the region of the polycystic kidney disease gene (PKD1)”. Genomics 24 (1): 27–33. (November 1994). doi:10.1006/geno.1994.1578. PMID 7896286.
- ^ a b c “A cyclin without cyclin-dependent kinases: cyclin F controls genome stability through ubiquitin-mediated proteolysis”. Trends in Cell Biology 23 (3): 135–40. (March 2013). doi:10.1016/j.tcb.2012.10.011. PMC 3597434. PMID 23182110 .
- ^ “Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase”. Genes & Development 24 (4): 333–8. (February 2010). doi:10.1101/gad.1863810. PMC 2816732. PMID 20159953 .
- ^ “Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair”. Cell 149 (5): 1023–34. (May 2012). doi:10.1016/j.cell.2012.03.043. PMC 3616325. PMID 22632967 .
- ^ a b “SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation”. Nature 466 (7302): 138–42. (July 2010). Bibcode: 2010Natur.466..138D. doi:10.1038/nature09140. PMC 2946399. PMID 20596027 .
- ^ “Global identification of modular cullin-RING ligase substrates”. Cell 147 (2): 459–74. (October 2011). doi:10.1016/j.cell.2011.09.019. PMC 3226719. PMID 21963094 .
- ^ “NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules”. Molecular Biology of the Cell 17 (6): 2646–60. (June 2006). doi:10.1091/mbc.E05-12-1178. PMC 1474800. PMID 16571672 .
- ^ “NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization”. The Journal of Cell Biology 162 (6): 1017–29. (September 2003). doi:10.1083/jcb.200302129. PMC 2172854. PMID 12963707 .
- ^ “Cyclin F-Mediated Degradation of SLBP Limits H2A.X Accumulation and Apoptosis upon Genotoxic Stress in G2”. Molecular Cell 64 (3): 507–519. (November 2016). doi:10.1016/j.molcel.2016.09.010. PMC 5097008. PMID 27773672 .
- ^ “Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs”. Molecular Cell 74 (6): 1264–1277.e7. (June 2019). doi:10.1016/j.molcel.2019.04.010. PMC 6588466. PMID 31130363 .
- ^ “E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition”. The EMBO Journal 38 (20): e101443. (August 2019). doi:10.15252/embj.2018101443. PMC 6792013. PMID 31424118 .
- ^ a b c “CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia”. Nature Communications 7: 11253. (April 2016). Bibcode: 2016NatCo...711253W. doi:10.1038/ncomms11253. PMC 4835537. PMID 27080313 .
- ^ “Cyclin F: A component of an E3 ubiquitin ligase complex with roles in neurodegeneration and cancer”. The International Journal of Biochemistry & Cell Biology 89: 216–220. (August 2017). doi:10.1016/j.biocel.2017.06.011. PMID 28652210.
- ^ a b “ALS-linked CCNF variant disrupts motor neuron ubiquitin homeostasis.”. Human Molecular Genetics ddad063 (14): 2386–2398. (May 2023). doi:10.1093/hmg/ddad063. PMC 10652331. PMID 37220877 .
- ^ “CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia”. Nature Communications 7: 11253. (April 2016). Bibcode: 2016NatCo...711253W. doi:10.1038/ncomms11253. PMC 4835537. PMID 27080313 .
- ^ “Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex.”. Open Biology 7 (10): 170058. (Oct 2017). doi:10.1098/rsob.170058. PMC 5666078. PMID 29021214 .
- ^ “Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy.”. Cellular and Molecular Life Sciences 75 (2): 335–354. (Jan 2018). doi:10.1007/s00018-017-2632-8. PMC 11105586. PMID 28852778 .
- ^ “Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype”. Human Molecular Genetics 26 (14): 2616–2626. (July 2017). doi:10.1093/hmg/ddx136. PMID 28444311.
- ^ “Roles of F-box proteins in cancer”. Nature Reviews. Cancer 14 (4): 233–47. (April 2014). doi:10.1038/nrc3700. PMC 4306233. PMID 24658274 .
- ^ “Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis”. Molecular Cancer 8: 11. (February 2009). doi:10.1186/1476-4598-8-11. PMC 2662784. PMID 19250552 .
関連 文献
[- “YAC/P1 contigs defining the location of 56 microsatellite markers and several genes across a 3.4-cM interval on mouse chromosome 11”. Mammalian Genome 6 (5): 321–31. (May 1995). doi:10.1007/BF00364794. PMID 7626882.
- “Human cyclin F”. The EMBO Journal 13 (24): 6087–98. (December 1994). doi:10.1002/j.1460-2075.1994.tb06955.x. PMC 395587. PMID 7813445 .
- “SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box”. Cell 86 (2): 263–74. (July 1996). doi:10.1016/S0092-8674(00)80098-7. PMID 8706131.
- “Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction”. The EMBO Journal 19 (6): 1378–88. (March 2000). doi:10.1093/emboj/19.6.1378. PMC 305678. PMID 10716937 .
- “Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins”. The Journal of Biological Chemistry 277 (38): 35140–9. (September 2002). doi:10.1074/jbc.M205503200. PMID 12122006.
- “Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes”. Genome Research 16 (1): 55–65. (January 2006). doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560 .
外部 リンク
[- Human CCNF genome location and CCNF gene details page in the UCSC Genome Browser.