E2F
E2Fは、
E2Fファミリー[編集 ]
E2Fファミリーのメンバーの
| ファミリーのメンバー | |
|---|---|
|
構造 [編集 ]
E2Fファミリーの
細胞 周期 における役割 [編集 ]
E2Fファミリーのメンバーは
E2Fファミリーは、
E2Fアクチベーターのレベルは
転写 標的 [編集 ]
細胞 周期 : CCNA1、CCNA2、CCND1、CCND2、CDK2、MYB、 E2F1、E2F2、E2F3、TFDP1、CDC25A負 の調節 因子 : E2F7、RB1、TP107、TP21細胞 周期 チェックポイント: TP53、BRCA1、BRCA2、BUB1- アポトーシス: TP73、APAF1、CASP3、CASP7、CASP8、MAP3K5、MAP3K14
- ヌクレオチド
合成 : チミジンキナーゼ（tk）、チミジル酸 シンターゼ（ts）、DHFR - DNA
修復 : BARD1、RAD51、UNG1,2、FANCA、FANCC、FANCJ - DNA
複製 : PCNA、ヒストンH2A、DNAポリメラーゼα 、DNAポリメラーゼδ 、RPA1、RPA2、RPA3、CDC6、MCM2、MCM3、MCM4、MCM5、MCM6、MCM7
出典 [編集 ]
- ^ “Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP”. Genes & Development 13 (6): 666–74. (March 1999). doi:10.1101/gad.13.6.666. PMC 316551. PMID 10090723.
- ^ a b c “E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control”. Molecular Cell 6 (3): 729–35. (September 2000). doi:10.1016/S1097-2765(00)00071-X. PMID 11030352.
- ^ “Mouse development with a single E2F activator”. Nature 454 (7208): 1137–41. (August 2008). Bibcode: 2008Natur.454.1137T. doi:10.1038/nature07066. PMC 4288824. PMID 18594513.
- ^ “Interplay between Arabidopsis activating factors E2Fb and E2Fa in cell cycle progression and development”. Plant Physiology 140 (4): 1355–66. (April 2006). doi:10.1104/pp.106.077990. PMC 1435807. PMID 16514015.
- ^ “Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation”. The Journal of Biological Chemistry 280 (18): 18211–20. (May 2005). doi:10.1074/jbc.M501410200. PMID 15722552.
- ^ “Emerging roles of E2Fs in cancer: an exit from cell cycle control”. Nature Reviews. Cancer 9 (11): 785–97. (November 2009). doi:10.1038/nrc2696. PMC 3616489. PMID 19851314.
- ^ “Expression of transcription factor E2F1 induces quiescent cells to enter S phase”. Nature 365 (6444): 349–52. (September 1993). Bibcode: 1993Natur.365..349J. doi:10.1038/365349a0. PMID 8377827.
- ^ “E2f1, E2f2, and E2f3 control E2F target expression and cellular proliferation via a p53-dependent negative feedback loop”. Molecular and Cellular Biology 27 (1): 65–78. (January 2007). doi:10.1128/MCB.02147-06. PMC 1800646. PMID 17167174.
- ^ “Pocket proteins and cell cycle control”. Oncogene 24 (17): 2796–809. (April 2005). doi:10.1038/sj.onc.1208619. PMID 15838516.
- ^ “Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation”. The Journal of Biological Chemistry 280 (18): 18211–20. (May 2005). doi:10.1074/jbc.M501410200. PMID 15722552.
- ^ “A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells”. Science 296 (5570): 1132–6. (May 2002). Bibcode: 2002Sci...296.1132O. doi:10.1126/science.1069861. PMID 12004135.
- ^ “In vivo structure of the human cdc2 promoter: release of a p130-E2F-4 complex from sequences immediately upstream of the transcription initiation site coincides with induction of cdc2 expression”. Molecular and Cellular Biology 15 (12): 6901–13. (December 1995). doi:10.1128/mcb.15.12.6901. PMC 230945. PMID 8524257.
- ^ “Cell cycle regulation of E2F site occupation in vivo”. Science 271 (5255): 1595–7. (March 1996). Bibcode: 1996Sci...271.1595Z. doi:10.1126/science.271.5255.1595. PMID 8599118.
- ^ “Systems Biology-Based Identifi cation of Crosstalk between E2F Transcription Factors and the Fanconi Anemia Pathway”. Gene Regulation and Systems Biology 1 (1): 1–7. (2007). doi:10.1177/117762500700100001. PMC 2759144. PMID 19936073.