eIF4F
![](https://upload.wikimedia.org/wikipedia/commons/thumb/0/04/EIF4G-eIF4E-m7G_solution_structure.png/300px-EIF4G-eIF4E-m7G_solution_structure.png)
eIF4F(eukaryotic initiation factor 4F)は、mRNAの5'キャップに
機能
[eIF4Fは、キャップ
構造
[eIF4Fの
サブユニット
[eIF4Fを
サブユニット | アイソフォーム | ||
---|---|---|---|
eIF4A | 46k | eIF4A1, eIF4A2, eIF4A3 | DEADボックスRNAヘリカーゼ。mRNA、eIF4G、eIF4B、eIF4H、PDCD4に |
eIF4E | 25k | eIF4E1, eIF4E2, eIF4E3 | キャップ |
eIF4G | 175k | eIF4G1, eIF4G3 |
A ヒト
eIF4F
調節
[eIF4FのeIF4Eサブユニットは、eIF4E
出典
[- ^ Gross, John D.; Moerke, Nathan J.; von der Haar, Tobias; Lugovskoy, Alexey A.; Sachs, Alan B.; McCarthy, John E.G.; Wagner, Gerhard (2003). “Ribosome Loading onto the mRNA Cap Is Driven by Conformational Coupling between eIF4G and eIF4E”. Cell (Elsevier BV) 115 (6): 739–750. doi:10.1016/s0092-8674(03)00975-9. ISSN 0092-8674. PMID 14675538.
- ^ “A mechanistic overview of translation initiation in eukaryotes”. Nature Structural & Molecular Biology 19 (6): 568–76. (June 2012). doi:10.1038/nsmb.2303. PMID 22664984.
- ^ a b c d e f g h “eIF4F: a retrospective”. The Journal of Biological Chemistry 290 (40): 24091–9. (October 2015). doi:10.1074/jbc.R115.675280. PMC 4591800. PMID 26324716 .
- ^ “Quantitative studies of mRNA recruitment to the eukaryotic ribosome”. Biochimie 114: 58–71. (July 2015). doi:10.1016/j.biochi.2015.02.017. PMC 4458453. PMID 25742741 .
- ^ “Circularization of mRNA by eukaryotic translation initiation factors”. Molecular Cell 2 (1): 135–40. (July 1998). doi:10.1016/S1097-2765(00)80122-7. PMID 9702200.
- ^ “Hippuristanol - A potent steroid inhibitor of eukaryotic initiation factor 4A”. Translation 4 (1): e1137381. (January 2016). doi:10.1080/21690731.2015.1137381. PMC 4909409. PMID 27335721 .
- ^ “Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor”. Nature 534 (7608): 558–61. (June 2016). Bibcode: 2016Natur.534..558I. doi:10.1038/nature17978. PMC 4946961. PMID 27309803 .
- ^ “Inhibition of eukaryotic translation initiation by the marine natural product pateamine A”. Molecular Cell 20 (5): 709–22. (December 2005). doi:10.1016/j.molcel.2005.10.008. PMID 16337595.