IRS4

IRS4
識別子しきべつし
記号きごう	IRS4, IRS-4, PY160, insulin receptor substrate 4, CHNG9
外部がいぶID	OMIM: 300904 MGI: 1338009 HomoloGene: 136777 GeneCards: IRS4
遺伝子いでんしの位置いち (ヒト)
染色せんしょく体たい	X染色せんしょく体たい
終点しゅうてん	108,736,563 bp
遺伝子いでんしの位置いち (マウス)
染色せんしょく体たい	X染色せんしょく体たい (マウス)
終点しゅうてん	140,508,259 bp
RNA発現はつげんパターン
	さらなる参照さんしょう発現はつげんデータ
遺伝子いでんしオントロジー
分子ぶんし機能きのう	• phosphatidylinositol 3-kinase binding; • 血漿けっしょうタンパク結合けつごう; • シグナルトランスデューサー活性かっせい; • insulin receptor binding;
細胞さいぼうの構成こうせい要素ようそ	• 細胞さいぼう質しつ基質きしつ; • 膜まく; • 細胞さいぼう膜まく;
生物せいぶつ学がく的てきプロセス	• insulin receptor signaling pathway; • regulation of lipid metabolic process; • シグナル伝達でんたつ; • positive regulation of signal transduction;
	出典しゅってん:Amigo / QuickGO
オルソログ
	8471
	16370
	ENSG00000133124
	ENSMUSG00000054667
	O14654
	Q9Z0Y7
	NM_003604; NM_001379150
	NM_010572
	NP_003595; NP_001366079
	NP_034702
	ウィキデータ
閲覧えつらん/編集へんしゅうヒト	閲覧えつらん/編集へんしゅうマウス

IRS4（insulin receptor substrate 4、インスリン受容じゅよう体たい基質きしつ4）は、ヒトではIRS4遺伝子いでんしによってコードされるタンパク質たんぱくしつである^[5]^[6]^[7]。

IRS4は細胞さいぼう質しつに位置いちするタンパク質たんぱくしつで、リン酸化さんかが行おこなわれる可能かのう性せいがあるチロシン、セリン/スレオニン残ざん基もとを多おおく持もつ。チロシンリン酸化さんかIRS4タンパク質たんぱくしつはSH2ドメインを持もつ細胞さいぼう質しつのシグナル伝達でんたつ分子ぶんしと結合けつごうすることが示しめされている。IRS4はインスリン受容じゅよう体たいの刺激しげきに伴ともなってリン酸化さんかされる^[7]。

相互そうご作用さよう

ISR4はCRK（英語えいご版ばん）^[8]^[9]、NISCH（英語えいご版ばん）^[10]と相互そうご作用さようすることが示しめされている。

出典しゅってん

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000133124 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054667 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ “A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family”. J Biol Chem 272 (34): 21403–7. (Sep 1997). doi:10.1074/jbc.272.34.21403. PMID 9261155.
^ “Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells”. J Biol Chem 273 (17): 10726–32. (May 1998). doi:10.1074/jbc.273.17.10726. PMID 9553137.
^ ^a ^b “Entrez Gene: IRS4 insulin receptor substrate 4”. 2021年ねん9月がつ7日にち閲覧えつらん。
^ Karas, M; Koval A P; Zick Y; LeRoith D (May 2001). “The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II”. Endocrinology (United States) 142 (5): 1835–40. doi:10.1210/en.142.5.1835. ISSN 0013-7227. PMID 11316748.
^ Koval, A P; Karas M; Zick Y; LeRoith D (Jun 1998). “Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction”. J. Biol. Chem. (UNITED STATES) 273 (24): 14780–7. doi:10.1074/jbc.273.24.14780. ISSN 0021-9258. PMID 9614078.
^ Sano, Hiroyuki; Liu Simon C H; Lane William S; Piletz John E; Lienhard Gustav E (May 2002). “Insulin receptor substrate 4 associates with the protein IRAS”. J. Biol. Chem. (United States) 277 (22): 19439–47. doi:10.1074/jbc.M111838200. ISSN 0021-9258. PMID 11912194.

関連かんれん文献ぶんけん

White MF (1999). “The IRS-signalling system: a network of docking proteins that mediate insulin action.”. Mol. Cell. Biochem. 182 (1–2): 3–11. doi:10.1023/A:1006806722619. PMID 9609109.
“Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction.”. J. Biol. Chem. 273 (24): 14780–7. (1998). doi:10.1074/jbc.273.24.14780. PMID 9614078.
“IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis.”. Mol. Cell. Biol. 20 (1): 126–38. (2000). doi:10.1128/MCB.20.1.126-138.2000. PMC 85068. PMID 10594015.
“The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II.”. Endocrinology 142 (5): 1835–40. (2001). doi:10.1210/en.142.5.1835. PMID 11316748.
“Insulin receptor substrate 4 associates with the protein IRAS.”. J. Biol. Chem. 277 (22): 19439–47. (2002). doi:10.1074/jbc.M111838200. PMID 11912194.
“SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.”. Mol. Cell. Biol. 22 (13): 4567–78. (2002). doi:10.1128/MCB.22.13.4567-4578.2002. PMC 133908. PMID 12052866.
“Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor.”. Endocrinology 144 (4): 1211–8. (2003). doi:10.1210/en.2002-220723. PMID 12639902.
“Insulin receptor substrate-4 signaling in quiescent rat hepatocytes and in regenerating rat liver.”. Hepatology 37 (6): 1461–9. (2003). doi:10.1053/jhep.2003.50245. PMID 12774026.
“Selective alterations in insulin receptor substrates-1, -2 and -4 in theca but not granulosa cells from polycystic ovaries.”. Mol. Hum. Reprod. 10 (7): 473–9. (2005). doi:10.1093/molehr/gah066. PMID 15155816.
“Tyrosine phosphoproteomics of fibroblast growth factor signaling: a role for insulin receptor substrate-4.”. J. Biol. Chem. 279 (45): 46438–47. (2004). doi:10.1074/jbc.M404537200. PMID 15316024.
“Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.”. Curr. Biol. 14 (16): 1436–50. (2004). doi:10.1016/j.cub.2004.07.051. PMID 15324660.
“Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation.”. J. Biol. Chem. 279 (45): 46588–94. (2004). doi:10.1074/jbc.M408067200. PMID 15331607.
“Interaction between Brk kinase and insulin receptor substrate-4.”. Oncogene 24 (36): 5656–64. (2005). doi:10.1038/sj.onc.1208721. PMID 15870689.
“Role of insulin receptor substrate-4 in IGF-I-stimulated HEPG2 proliferation.”. J. Hepatol. 46 (6): 1089–98. (2007). doi:10.1016/j.jhep.2007.01.031. PMID 17408801.

この項目こうもくは、生物せいぶつ学がくに関連かんれんした書かきかけの項目こうもくです。この項目こうもくを加筆かひつ・訂正ていせいなどしてくださる協力きょうりょく者しゃを求もとめています（プロジェクト:生命せいめい科学かがく／Portal:生物せいぶつ学がく）。

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000133124 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054667 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

[pmid9261155-5] “A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family”. J Biol Chem 272 (34): 21403–7. (Sep 1997). doi:10.1074/jbc.272.34.21403. PMID 9261155.

[pmid9553137-6] “Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells”. J Biol Chem 273 (17): 10726–32. (May 1998). doi:10.1074/jbc.273.17.10726. PMID 9553137.

[entrez-7] “Entrez Gene: IRS4 insulin receptor substrate 4”. 2021年ねん9月がつ7日にち閲覧えつらん。

[pmid11316748-8] Karas, M; Koval A P; Zick Y; LeRoith D (May 2001). “The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II”. Endocrinology (United States) 142 (5): 1835–40. doi:10.1210/en.142.5.1835. ISSN 0013-7227. PMID 11316748.

[pmid9614078-9] Koval, A P; Karas M; Zick Y; LeRoith D (Jun 1998). “Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction”. J. Biol. Chem. (UNITED STATES) 273 (24): 14780–7. doi:10.1074/jbc.273.24.14780. ISSN 0021-9258. PMID 9614078.

[pmid11912194-10] Sano, Hiroyuki; Liu Simon C H; Lane William S; Piletz John E; Lienhard Gustav E (May 2002). “Insulin receptor substrate 4 associates with the protein IRAS”. J. Biol. Chem. (United States) 277 (22): 19439–47. doi:10.1074/jbc.M111838200. ISSN 0021-9258. PMID 11912194.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]