SMARCA4
SMARCA4(SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4)もしくはBRG1(BRM/SWI2-related gene 1)は、ヒトではSMARCA4
機能
[SMARCA4
SMARCA4(BRG1)は
臨床 的 意義
[SMARCA4(BRG1)は、がんで
がんにおけるBRG1の
BRG1の
相互 作用
[
SMARCA4は
- ACTL6A[20][21]
- ARID1A[20][21]
- ARID1B[22][23]
- BRCA1[24][25]
- CTNNB1[26]
- CBX5[27]
- CREBBP[28][29]
- CCNE1[30][31]
- ESR1[28][32]
- FANCA[33][34]
- HSP90B1[33]
- ING1[35]
- Myc[36][37]
- NR3C1[38][39]
- P53[40]
- POLR2A[20][21][41]
- PHB[42]
- SIN3A[35][41]
- SMARCB1[20][21][33][41][43]
- SMARCC1[20][21][33][41]
- SMARCC2[20][21][33]
- SMARCE1[20][21]
- STAT2[44]
- STK11[45]
出典
[- ^ a b c GRCh38: Ensembl release 89: ENSG00000127616 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032187 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor”. Nucleic Acids Research 22 (10): 1815–20. (May 1994). doi:10.1093/nar/22.10.1815. PMC 308079. PMID 8208605 .
- ^ “Entrez Gene: SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4”. 2023
年 4月 30日 閲覧 。 - ^ “An essential role for a mammalian SWI/SNF chromatin-remodeling complex during male meiosis”. Development 139 (6): 1133–40. (March 2012). doi:10.1242/dev.073478. PMC 3283123. PMID 22318225 .
- ^ “SWI/SNF complexes containing Brahma or Brahma-related gene 1 play distinct roles in smooth muscle development”. Molecular and Cellular Biology 31 (13): 2618–31. (July 2011). doi:10.1128/MCB.01338-10. PMC 3133369. PMID 21518954 .
- ^ a b “The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer”. Cold Spring Harbor Perspectives in Medicine 6 (8): a026930. (August 2016). doi:10.1101/cshperspect.a026930. PMC 4968166. PMID 27413115 .
- ^ “The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest”. Cell 79 (1): 119–30. (October 1994). doi:10.1016/0092-8674(94)90405-7. PMID 7923370.
- ^ a b “Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines”. Human Mutation 29 (5): 617–22. (May 2008). doi:10.1002/humu.20730. PMID 18386774.
- ^ “Dissecting the genomic complexity underlying medulloblastoma”. Nature 488 (7409): 100–5. (August 2012). Bibcode: 2012Natur.488..100J. doi:10.1038/nature11284. PMC 3662966. PMID 22832583 .
- ^ “Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer”. Proceedings of the National Academy of Sciences of the United States of America 109 (5): E252–9. (January 2012). doi:10.1073/pnas.1114817109. PMC 3277150. PMID 22233809 .
- ^ “The spectrum of SWI/SNF mutations, ubiquitous in human cancers”. PLOS ONE 8 (1): e55119. (2013). Bibcode: 2013PLoSO...855119S. doi:10.1371/journal.pone.0055119. PMC 3552954. PMID 23355908 .
- ^ a b c d “Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers”. Nature Structural & Molecular Biology 25 (1): 61–72. (January 2018). doi:10.1038/s41594-017-0007-3. PMC 5909405. PMID 29323272 .
- ^ a b “Smarca4 ATPase mutations disrupt direct eviction of PRC1 from chromatin”. Nature Genetics 49 (2): 282–288. (February 2017). doi:10.1038/ng.3735. PMC 5373480. PMID 27941795 .
- ^ “The SWI/SNF genetic blockade: effects in cell differentiation, cancer and developmental diseases”. Oncogene 33 (21): 2681–9. (May 2014). doi:10.1038/onc.2013.227. PMID 23752187.
- ^ “The tumour suppressor and chromatin-remodelling factor BRG1 antagonizes Myc activity and promotes cell differentiation in human cancer”. EMBO Molecular Medicine 4 (7): 603–16. (July 2012). doi:10.1002/emmm.201200236. PMC 3407948. PMID 22407764 .
- ^ “The novel arsenical Darinaparsin circumvents BRG1-dependent, HO-1-mediated cytoprotection in leukemic cells”. Leukemia 27 (11): 2220–8. (November 2013). doi:10.1038/leu.2013.54. PMID 23426167.
- ^ a b c d e f g “Purification and biochemical heterogeneity of the mammalian SWI-SNF complex”. The EMBO Journal 15 (19): 5370–82. (October 1996). doi:10.1002/j.1460-2075.1996.tb00921.x. PMC 452280. PMID 8895581 .
- ^ a b c d e f g “Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling”. Cell 95 (5): 625–36. (November 1998). doi:10.1016/S0092-8674(00)81633-5. PMID 9845365.
- ^ “Cloning and characterization of hELD/OSA1, a novel BRG1 interacting protein”. The Biochemical Journal 364 (Pt 1): 255–64. (May 2002). doi:10.1042/bj3640255. PMC 1222568. PMID 11988099 .
- ^ “Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors”. The Journal of Biological Chemistry 277 (44): 41674–85. (November 2002). doi:10.1074/jbc.M205961200. PMID 12200431.
- ^ “BRCA1 interacts with dominant negative SWI/SNF enzymes without affecting homologous recombination or radiation-induced gene activation of p21 or Mdm2”. Journal of Cellular Biochemistry 91 (5): 987–98. (April 2004). doi:10.1002/jcb.20003. PMID 15034933.
- ^ “BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer”. Cell 102 (2): 257–65. (July 2000). doi:10.1016/S0092-8674(00)00030-1. PMID 10943845.
- ^ “The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation”. The EMBO Journal 20 (17): 4935–43. (September 2001). doi:10.1093/emboj/20.17.4935. PMC 125268. PMID 11532957 .
- ^ “Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1alpha”. The EMBO Journal 21 (21): 5797–806. (November 2002). doi:10.1093/emboj/cdf560. PMC 131057. PMID 12411497 .
- ^ a b “BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation”. Molecular and Cellular Biology 20 (20): 7541–9. (October 2000). doi:10.1128/MCB.20.20.7541-7549.2000. PMC 86306. PMID 11003650 .
- ^ “Factors associated with the mammalian RNA polymerase II holoenzyme”. Nucleic Acids Research 26 (3): 847–53. (February 1998). doi:10.1093/nar/26.3.847. PMC 147327. PMID 9443979 .
- ^ “BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines”. Cancer Research 60 (21): 6171–7. (November 2000). PMID 11085541.
- ^ “Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest”. Molecular and Cellular Biology 19 (2): 1460–9. (February 1999). doi:10.1128/mcb.19.2.1460. PMC 116074. PMID 9891079 .
- ^ “Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2”. Gene 188 (1): 95–100. (March 1997). doi:10.1016/S0378-1119(96)00785-8. PMID 9099865.
- ^ a b c d e “Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex”. Human Molecular Genetics 10 (23): 2651–60. (November 2001). doi:10.1093/hmg/10.23.2651. PMID 11726552.
- ^ “Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport”. Experimental Cell Research 289 (2): 211–21. (October 2003). doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
- ^ a b “Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)”. Molecular and Cellular Biology 22 (3): 835–48. (February 2002). doi:10.1128/MCB.22.3.835-848.2002. PMC 133546. PMID 11784859 .
- ^ “Large-scale mapping of human protein-protein interactions by mass spectrometry”. Molecular Systems Biology 3 (1): 89. (2007). doi:10.1038/msb4100134. PMC 1847948. PMID 17353931 .
- ^ “BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation”. Molecular and Cellular Biology 22 (5): 1307–16. (March 2002). doi:10.1128/MCB.22.5.1307-1316.2002. PMC 134713. PMID 11839798 .
- ^ “BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation”. Molecular and Cellular Biology 23 (17): 6210–20. (September 2003). doi:10.1128/MCB.23.17.6210-6220.2003. PMC 180928. PMID 12917342 .
- ^ “Recruitment of the SWI-SNF chromatin remodeling complex as a mechanism of gene activation by the glucocorticoid receptor tau1 activation domain”. Molecular and Cellular Biology 20 (6): 2004–13. (March 2000). doi:10.1128/MCB.20.6.2004-2013.2000. PMC 110817. PMID 10688647 .
- ^ “SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription”. The Journal of Biological Chemistry 277 (25): 22330–7. (June 2002). doi:10.1074/jbc.M111987200. PMID 11950834.
- ^ a b c d “Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes”. Genes & Development 15 (5): 603–18. (March 2001). doi:10.1101/gad.872801. PMC 312641. PMID 11238380 .
- ^ “Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth”. The EMBO Journal 21 (12): 3019–28. (June 2002). doi:10.1093/emboj/cdf302. PMC 126057. PMID 12065415 .
- ^ “Transcriptional activation domains of human heat shock factor 1 recruit human SWI/SNF”. Molecular and Cellular Biology 21 (17): 5826–37. (September 2001). doi:10.1128/MCB.21.17.5826-5837.2001. PMC 87302. PMID 11486022 .
- ^ “Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-alpha-inducible genes”. Nature Cell Biology 4 (10): 774–81. (October 2002). doi:10.1038/ncb855. PMID 12244326.
- ^ “LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest”. The Journal of Biological Chemistry 276 (35): 32415–8. (August 2001). doi:10.1074/jbc.C100207200. PMID 11445556.
関連 文献
[- “Involvement of the chromatin-remodeling factor BRG1/SMARCA4 in human cancer”. Epigenetics 3 (2): 64–8. (2008). doi:10.4161/epi.3.2.6153. PMID 18437052.
- “Sensing stress and responding to stress”. Stress-Inducible Cellular Responses. 77. (1996). 121–37. doi:10.1007/978-3-0348-9088-5_9. ISBN 978-3-0348-9901-7. PMID 8856972
- “Chromatin remodeling: nucleosomes bulging at the seams”. Current Biology 12 (7): R245–7. (April 2002). doi:10.1016/S0960-9822(02)00782-0. PMID 11937040.