GPR50 — разлика између измена

G protein-spregnuti receptor 50
G protein-spregnuti receptor 50
Identifikatori
Simboli	GPR50; H9; MGC125342
Vanjski ID	OMIM: 300207 MGI: 1333877 HomoloGene: 3113 IUPHAR: GPR50 GeneCards: GPR50 Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu sličnog receptora; • receptorska aktivnost;
Celularna komponenta	• integralno sa ćelijskom membranom; • membrana;
Biološki proces	• prenos signala; • signalni put G-protein spregnutog receptora; • međućelijska signalizacija;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	9248
Ensembl	ENSG00000102195
UniProt	Q13585
RefSeq (mRNA)	NM_004224
RefSeq (protein)	NP_004215
Lokacija (UCSC)	Chr X:; 150.1 - 150.1 Mb
PubMed pretraga	[1]

Интерактиван преглед историје

← Старија измена

Садржај обрисан Садржај додат

ВизуелноВикитекст

Инлајн

Тренутна верзија на датум 7. април 2024. у 23:06

GPR50, G protein-spregnuti receptor 50, je protein koji je kod čoveka kodiran GPR50 genom.^[1]^[2]^[3]

Funkcija

GPR50 je član GPCR familije integralnih membranskih proteina. On je sličan melatoninskom receptoru.^[2] GPR50 ima sposobnost formiranja heterodimera sa MT₁ i MT₂ melatoninskim receptorima. Dok GPR50 nema uticaja na MT₂ funkciju, on sprečava MT₁ da veže melatonin i formira kompleks sa G proteinima.^[4]

Klinički značaj

Određeni polimorfizmi GPR50 gena kod žena su povezani sa povišenim rizikom razvoja bipolarnog poremećaja, kliničkom depresijom, i šizofrenijom.^[5] Drugi GPR50 genski polimorfizmi uslovljavaju povišenje nivoa cirkulišućih triglicerida i sniženje nivoa cirkulišućih lipoproteina visoke gustine.^[6]

Reference

^ „Entrez Gene: GPR50 G protein-coupled receptor 50”.
^ ^а ^б Reppert SM, Weaver DR, Ebisawa T, Mahle CD, Kolakowski LF (1996). „Cloning of a melatonin-related receptor from human pituitary”. FEBS letters. 386 (2-3): 219—24. PMID 8647286. doi:10.1016/0014-5793(96)00437-1.
^ Gubitz AK, Reppert SM (1999). „Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50)”. Genomics. 55 (2): 248—51. PMID 9933574. doi:10.1006/geno.1998.5661.
^ Levoye A, Dam J, Ayoub MA, Guillaume JL, Couturier C, Delagrange P, Jockers R (2006). „The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization”. The EMBO journal. 25 (13): 3012—23. PMC 1500982 . PMID 16778767. doi:10.1038/sj.emboj.7601193.
^ Thomson PA, Wray NR, Thomson AM, Dunbar DR, Grassie MA, Condie A, Walker MT, Smith DJ, Pulford DJ, Muir W, Blackwood DH, Porteous DJ (2005). „Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor”. Molecular psychiatry. 10 (5): 470—8. PMID 15452587. doi:10.1038/sj.mp.4001593.
^ Bhattacharyya S, Luan J, Challis B, Keogh J, Montague C, Brennand J, Morten J, Lowenbeim S, Jenkins S, Farooqi IS, Wareham NJ, O'Rahilly S (2006). „Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels”. Journal of lipid research. 47 (4): 761—6. PMID 16436372. doi:10.1194/jlr.M500338-JLR200.

Literatura

Reppert SM; Weaver DR; Ebisawa T; et al. (1996). „Cloning of a melatonin-related receptor from human pituitary.”. FEBS Lett. 386 (2-3): 219—24. PMID 8647286. doi:10.1016/0014-5793(96)00437-1.
Gubitz AK, Reppert SM (1999). „Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50).”. Genomics. 55 (2): 248—51. PMID 9933574. doi:10.1006/geno.1998.5661.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Slominski A; Pisarchik A; Zbytek B; et al. (2003). „Functional activity of serotoninergic and melatoninergic systems expressed in the skin.”. J. Cell. Physiol. 196 (1): 144—53. PMID 12767050. doi:10.1002/jcp.10287.
Suzuki Y; Yamashita R; Shirota M; et al. (2004). „Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.”. Genome Res. 14 (9): 1711—8. PMC 515316 . PMID 15342556. doi:10.1101/gr.2435604.
Thomson PA; Wray NR; Thomson AM; et al. (2005). „Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor.”. Mol. Psychiatry. 10 (5): 470—8. PMID 15452587. doi:10.1038/sj.mp.4001593.
Bhattacharyya S; Luan J; Challis B; et al. (2006). „Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels.”. J. Lipid Res. 47 (4): 761—6. PMID 16436372. doi:10.1194/jlr.M500338-JLR200.
Levoye A; Dam J; Ayoub MA; et al. (2006). „The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization.”. EMBO J. 25 (13): 3012—23. PMC 1500982 . PMID 16778767. doi:10.1038/sj.emboj.7601193.

[entrez-1] „Entrez Gene: GPR50 G protein-coupled receptor 50”.

[pmid8647286-2] а ^б Reppert SM, Weaver DR, Ebisawa T, Mahle CD, Kolakowski LF (1996). „Cloning of a melatonin-related receptor from human pituitary”. FEBS letters. 386 (2-3): 219—24. PMID 8647286. doi:10.1016/0014-5793(96)00437-1.

[pmid9933574-3] Gubitz AK, Reppert SM (1999). „Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50)”. Genomics. 55 (2): 248—51. PMID 9933574. doi:10.1006/geno.1998.5661.

[pmid16778767-4] Levoye A, Dam J, Ayoub MA, Guillaume JL, Couturier C, Delagrange P, Jockers R (2006). „The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization”. The EMBO journal. 25 (13): 3012—23. PMC 1500982 . PMID 16778767. doi:10.1038/sj.emboj.7601193.

[pmid15452587-5] Thomson PA, Wray NR, Thomson AM, Dunbar DR, Grassie MA, Condie A, Walker MT, Smith DJ, Pulford DJ, Muir W, Blackwood DH, Porteous DJ (2005). „Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor”. Molecular psychiatry. 10 (5): 470—8. PMID 15452587. doi:10.1038/sj.mp.4001593.

[pmid16436372-6] Bhattacharyya S, Luan J, Challis B, Keogh J, Montague C, Brennand J, Morten J, Lowenbeim S, Jenkins S, Farooqi IS, Wareham NJ, O'Rahilly S (2006). „Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels”. Journal of lipid research. 47 (4): 761—6. PMID 16436372. doi:10.1194/jlr.M500338-JLR200.

[1]

[2]

[3]

[4]

[5]

[6]

@@ Ред 1: / Ред 1: @@
 __NOTC__
 {{PBB|geneid=9248}}
--{'''GPR50'''}-, ''G protein-spregnuti receptor 50'', je [[protein]] koji je kod čoveka kodiran -{''GPR50''}- [[gen]]om.<ref name="entrez">{{cite web | title = Entrez Gene: GPR50 G protein-coupled receptor 50| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9248| accessdate = }}</ref><ref name="pmid8647286">{{cite journal | author = Reppert SM, Weaver DR, Ebisawa T, Mahle CD, Kolakowski LF | title = Cloning of a melatonin-related receptor from human pituitary | journal = FEBS letters | volume = 386 | issue = 2-3 | pages = 219–24 | year = 1996 | month = May | pmid = 8647286 | doi = 10.1016/0014-5793(96)00437-1 | url =  | issn = }}</ref><ref name="pmid9933574">{{cite journal | author = Gubitz AK, Reppert SM | title = Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50) | journal = Genomics | volume = 55 | issue = 2 | pages = 248–51 | year = 1999 | month = January | pmid = 9933574 | doi = 10.1006/geno.1998.5661 | url = | issn = }}</ref>
+-{'''GPR50'''}-, ''G protein-spregnuti receptor 50'', je [[protein]] koji je kod čoveka kodiran -{''GPR50''}- [[gen]]om.<ref name="entrez">{{cite web | title = Entrez Gene: GPR50 G protein-coupled receptor 50| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9248| accessdate = }}</ref><ref name="pmid8647286">{{cite journal |vauthors=Reppert SM, Weaver DR, Ebisawa T, Mahle CD, Kolakowski LF | title = Cloning of a melatonin-related receptor from human pituitary | journal = FEBS letters | volume = 386 | issue = 2-3 | pages = 219–24 | year = 1996 | pmid = 8647286 | doi = 10.1016/0014-5793(96)00437-1 | url =  | issn = }}</ref><ref name="pmid9933574">{{cite journal |vauthors=Gubitz AK, Reppert SM | title = Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50) | journal = Genomics | volume = 55 | issue = 2 | pages = 248–51 | year = 1999 | pmid = 9933574 | doi = 10.1006/geno.1998.5661 | url = | issn = }}</ref>
 == Funkcija ==
--{GPR50}- je član [[GPCR]] familije [[Integralni membranski protein|integralnih membranskih proteina]]. On je sličan [[melatoninski receptor|melatoninskom receptoru]].<ref name="pmid8647286"/> -{GPR50}- ima sposobnost formiranja heterodimera sa [[melatoninski receptor 1A|MT<sub>1</sub>]] i [[melatoninski receptor 1B|MT<sub>2</sub>]] melatoninskim receptorima. Dok -{GPR50}- nema uticaja na MT<sub>2</sub> funkciju, on sprečava MT<sub>1</sub> da veže [[melatonin]] i formira kompleks sa [[G protein]]ima.<ref name="pmid16778767">{{cite journal | author = Levoye A, Dam J, Ayoub MA, Guillaume JL, Couturier C, Delagrange P, Jockers R | title = The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization | journal = The EMBO journal | volume = 25 | issue = 13 | pages = 3012–23 | year = 2006 | month = July | pmid = 16778767 | pmc = 1500982 | doi = 10.1038/sj.emboj.7601193 | url = | issn = }}</ref>
+-{GPR50}- je član [[G protein spregnuti receptori|GPCR]] familije [[Integralni membranski protein|integralnih membranskih proteina]]. On je sličan [[melatoninski receptor|melatoninskom receptoru]].<ref name="pmid8647286"/> -{GPR50}- ima sposobnost formiranja heterodimera sa [[melatoninski receptor 1A|MT<sub>1</sub>]] i [[melatoninski receptor 1B|MT<sub>2</sub>]] melatoninskim receptorima. Dok -{GPR50}- nema uticaja na MT<sub>2</sub> funkciju, on sprečava MT<sub>1</sub> da veže [[melatonin]] i formira kompleks sa [[G protein]]ima.<ref name="pmid16778767">{{cite journal |vauthors=Levoye A, Dam J, Ayoub MA, Guillaume JL, Couturier C, Delagrange P, Jockers R | title = The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization | journal = The EMBO journal | volume = 25 | issue = 13 | pages = 3012–23 | year = 2006 | pmid = 16778767 | pmc = 1500982 | doi = 10.1038/sj.emboj.7601193 | url = | issn = }}</ref>
 == Klinički značaj ==
-Određeni [[Polimorfizam (biologija)|polimorfizmi]] -{''GPR50''}- gena kod žena su povezani sa povišenim rizikom razvoja [[Bipolarni poremećaj|bipolarnog poremećaja]], [[Klinička depresija|kliničkom depresijom]], i [[šizofrenija|šizofrenijom]].<ref name="pmid15452587">{{cite journal | author = Thomson PA, Wray NR, Thomson AM, Dunbar DR, Grassie MA, Condie A, Walker MT, Smith DJ, Pulford DJ, Muir W, Blackwood DH, Porteous DJ | title = Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor | journal = Molecular psychiatry | volume = 10 | issue = 5 | pages = 470–8 | year = 2005 | month = May | pmid = 15452587 | doi = 10.1038/sj.mp.4001593 | url = | issn = }}</ref> Drugi -{''GPR50''}- genski polimorfizmi uslovljavaju povišenje nivoa cirkulišućih [[triglicerid]]a i sniženje nivoa cirkulišućih [[lipoprotein visoke gustine|lipoproteina visoke gustine]].<ref name="pmid16436372">{{cite journal | author = Bhattacharyya S, Luan J, Challis B, Keogh J, Montague C, Brennand J, Morten J, Lowenbeim S, Jenkins S, Farooqi IS, Wareham NJ, O'Rahilly S| title = Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels | journal = Journal of lipid research | volume = 47 | issue = 4 | pages = 761–6 | year = 2006 | month = April | pmid = 16436372 | doi = 10.1194/jlr.M500338-JLR200 | url = | issn = }}</ref>
+Određeni [[Polimorfizam (biologija)|polimorfizmi]] -{''GPR50''}- gena kod žena su povezani sa povišenim rizikom razvoja [[Bipolarni poremećaj|bipolarnog poremećaja]], [[Klinička depresija|kliničkom depresijom]], i [[šizofrenija|šizofrenijom]].<ref name="pmid15452587">{{cite journal |vauthors=Thomson PA, Wray NR, Thomson AM, Dunbar DR, Grassie MA, Condie A, Walker MT, Smith DJ, Pulford DJ, Muir W, Blackwood DH, Porteous DJ | title = Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor | journal = Molecular psychiatry | volume = 10 | issue = 5 | pages = 470–8 | year = 2005 | pmid = 15452587 | doi = 10.1038/sj.mp.4001593 | url = | issn = }}</ref> Drugi -{''GPR50''}- genski polimorfizmi uslovljavaju povišenje nivoa cirkulišućih [[triglicerid]]a i sniženje nivoa cirkulišućih [[lipoprotein visoke gustine|lipoproteina visoke gustine]].<ref name="pmid16436372">{{cite journal |vauthors=Bhattacharyya S, Luan J, Challis B, Keogh J, Montague C, Brennand J, Morten J, Lowenbeim S, Jenkins S, Farooqi IS, Wareham NJ, O'Rahilly S | title = Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels | journal = Journal of lipid research | volume = 47 | issue = 4 | pages = 761–6 | year = 2006 | pmid = 16436372 | doi = 10.1194/jlr.M500338-JLR200 | url =https://archive.org/details/sim_journal-of-lipid-research_2006-04_47_4/page/761| issn = }}</ref>
-==Literatura==
+== Reference ==
 {{reflist|2}}
-==Dodatna literatura==
+== Literatura ==
-{{refbegin | 2}}
+{{Литература | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Reppert SM, Weaver DR, Ebisawa T, ''et al.'' |title=Cloning of a melatonin-related receptor from human pituitary. |journal=FEBS Lett. |volume=386 |issue= 2-3 |pages= 219–24 |year= 1996 |pmid= 8647286 |doi=10.1016/0014-5793(96)00437-1  }}
+*{{cite journal  |author1=Reppert SM |author2=Weaver DR |author3=Ebisawa T |author4=''et al.'' |title=Cloning of a melatonin-related receptor from human pituitary. |journal=FEBS Lett. |volume=386 |issue= 2-3 |pages= 219–24 |year= 1996 |pmid= 8647286 |doi=10.1016/0014-5793(96)00437-1  }}
-*{{cite journal  | author=Gubitz AK, Reppert SM |title=Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50). |journal=Genomics |volume=55 |issue= 2 |pages= 248–51 |year= 1999 |pmid= 9933574 |doi= 10.1006/geno.1998.5661 }}
+*{{cite journal  |vauthors=Gubitz AK, Reppert SM |title=Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50). |journal=Genomics |volume=55 |issue= 2 |pages= 248–51 |year= 1999 |pmid= 9933574 |doi= 10.1006/geno.1998.5661 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
+*{{cite journal  |author1=Strausberg RL |author2=Feingold EA |author3=Grouse LH |author4=''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Slominski A, Pisarchik A, Zbytek B, ''et al.'' |title=Functional activity of serotoninergic and melatoninergic systems expressed in the skin. |journal=J. Cell. Physiol. |volume=196 |issue= 1 |pages= 144–53 |year= 2003 |pmid= 12767050 |doi= 10.1002/jcp.10287 }}
+*{{cite journal  |author1=Slominski A |author2=Pisarchik A |author3=Zbytek B |author4=''et al.'' |title=Functional activity of serotoninergic and melatoninergic systems expressed in the skin. |journal=J. Cell. Physiol. |volume=196 |issue= 1 |pages= 144–53 |year= 2003 |pmid= 12767050 |doi= 10.1002/jcp.10287 }}
-*{{cite journal  | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604  | pmc=515316 }}
+*{{cite journal  |author1=Suzuki Y |author2=Yamashita R |author3=Shirota M |author4=''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604  | pmc=515316 }}
-*{{cite journal  | author=Thomson PA, Wray NR, Thomson AM, ''et al.'' |title=Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor. |journal=Mol. Psychiatry |volume=10 |issue= 5 |pages= 470–8 |year= 2005 |pmid= 15452587 |doi= 10.1038/sj.mp.4001593 }}
+*{{cite journal  |author1=Thomson PA |author2=Wray NR |author3=Thomson AM |author4=''et al.'' |title=Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor. |journal=Mol. Psychiatry |volume=10 |issue= 5 |pages= 470–8 |year= 2005 |pmid= 15452587 |doi= 10.1038/sj.mp.4001593 }}
-*{{cite journal  | author=Bhattacharyya S, Luan J, Challis B, ''et al.'' |title=Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels. |journal=J. Lipid Res. |volume=47 |issue= 4 |pages= 761–6 |year= 2006 |pmid= 16436372 |doi= 10.1194/jlr.M500338-JLR200 }}
+*{{cite journal  |author1=Bhattacharyya S |author2=Luan J |author3=Challis B |author4=''et al.'' |title=Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels. |url=https://archive.org/details/sim_journal-of-lipid-research_2006-04_47_4/page/761 |journal=J. Lipid Res. |volume=47 |issue= 4 |pages= 761–6 |year= 2006 |pmid= 16436372 |doi= 10.1194/jlr.M500338-JLR200 }}
-*{{cite journal  | author=Levoye A, Dam J, Ayoub MA, ''et al.'' |title=The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. |journal=EMBO J. |volume=25 |issue= 13 |pages= 3012–23 |year= 2006 |pmid= 16778767 |doi= 10.1038/sj.emboj.7601193  | pmc=1500982 }}
+*{{cite journal  |author1=Levoye A |author2=Dam J |author3=Ayoub MA |author4=''et al.'' |title=The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. |journal=EMBO J. |volume=25 |issue= 13 |pages= 3012–23 |year= 2006 |pmid= 16778767 |doi= 10.1038/sj.emboj.7601193  | pmc=1500982 }}
 }}
+{{Литература крај}}
-{{refend}}
 {{-}}
 {{G protein spregnuti receptori-lat}}
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