(Translated by https://www.hiragana.jp/)
PANTHER Gene Information   
Gene Symbol(s): Dif
Organism: Drosophila melanogaster
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Gene Name: Dorsal-related immunity factor Dif
Gene ID: FBgn0011274
Protein ID: P98149
Persistent Id: PTN001539228
Alternate Ids:
NP_001162999(refSeq) 24584818(GI)
FBtr0081008(Ensembl_TRS) AAN10989(EMBL-CDS)
FBgn0011274(FlyBase) 35045(GeneID)
FBgn0011274(Ensembl) FBpp0290793(Ensembl_PRO)
DIF(Synonym) Q8MT54(AltAccession)
DIF_DROME(UniProtKB-ID) AE014134(EMBL)
Dif{ECO:0000312|FlyBase:FBgn0011274}(Symbol)
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PANTHER Classification
PANTHER Family: NUCLEAR FACTOR NF-KAPPA-B PROTEIN (PTHR24169)
PANTHER Subfamily: DORSAL-RELATED IMMUNITY FACTOR DIF-RELATED (PTHR24169:SF25)  
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:
PANTHER protein class: Rel homology transcription factor
Pathway Categories: Toll pathway-drosophila
   dorsal
Toll receptor signaling pathway
   Nuclear factor kappa-B
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: DNA binding, DNA-binding transcription factor activity, protein binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific
GO BP Complete: Toll signaling pathway, response to cytokine, regulation of DNA-templated transcription, salivary gland histolysis, non-canonical NF-kappaB signal transduction, canonical NF-kappaB signal transduction, positive regulation of transcription by RNA polymerase II, peripheral nervous system neuron development, regulation of transcription by RNA polymerase II, positive regulation of antimicrobial peptide production, immune response, positive regulation of gene expression, innate immune response, positive regulation of antifungal peptide production, regulation of hemocyte proliferation, cellular response to stress, defense response to fungus, defense response to Gram-positive bacterium
GO CC Complete: nucleus, cytoplasm, cytosol, nucleoplasm
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Fc epsilon receptor (FCERI) signaling, Toll Like Receptor 3 (TLR3) Cascade, TCR signaling, Signal Transduction, Signaling by Interleukins, Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex', Post-translational protein modification, Downstream signaling events of B Cell Receptor (BCR), DDX58/IFIH1-mediated induction of interferon-alpha/beta, C-type lectin receptors (CLRs), RIP-mediated NFkB activation via ZBP1, Innate Immune System, TAK1-dependent IKK and NF-kappa-B activation , Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 9 (TLR9) Cascade, FCERI mediated NF-kB activation, Toll Like Receptor TLR1:TLR2 Cascade, Immune System, Metabolism of proteins, p75NTR signals via NF-kB, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, SUMO E3 ligases SUMOylate target proteins, Signaling by the B Cell Receptor (BCR), Drosophila signaling pathways, Toll-like Receptor Cascades, Toll Like Receptor TLR6:TLR2 Cascade, Toll Like Receptor 10 (TLR10) Cascade, Interleukin-1 family signaling, MyD88-independent TLR4 cascade , Downstream TCR signaling, Activation of NF-kappaB in B cells, Toll Like Receptor 7/8 (TLR7/8) Cascade, p75 NTR receptor-mediated signalling, Interleukin-1 signaling, SUMOylation of immune response proteins, DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex', DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex', DEx/H-box helicases activate type I IFN and inflammatory cytokines production , TRIF(TICAM1)-mediated TLR4 signaling , Cytosolic sensors of pathogen-associated DNA , TRAF6 mediated NF-kB activation, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Death Receptor Signaling, Toll pathway, Degradation of NF-kappa-B inhibitor, CACT, Transcriptional activtion by phosphorylated DL/DIF dimer, Adaptive Immune System, NF-kB is activated and signals survival, Cytokine Signaling in Immune system, CD209 (DC-SIGN) signaling, SUMOylation, MyD88 cascade initiated on plasma membrane, ZBP1(DAI) mediated induction of type I IFNs, MyD88 dependent cascade initiated on endosome, Toll Like Receptor 4 (TLR4) Cascade, CLEC7A (Dectin-1) signaling, Toll Like Receptor 2 (TLR2) Cascade

Orthologs