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神経しんけい科学かがく

5-HT Receptor

(556)

AAK1 (AP2 associated kinase 1)

Melanocortin Receptor

Neuropeptide Y Receptor

Serotonin Transporter

(46)

iGluR

(113)

BACE

Beta-secretase 1 (BACE1), also known as beta-site amyloid precursor protein cleaving enzyme 1, beta-site APP cleaving enzyme 1, membrane-associated aspartic protease 2, memapsin-2, aspartyl protease 2, and ASP2, is an enzyme that in humans is encoded by the BACE1 gene. Expression of BACE1 is observed mainly in neurons.BACE1 is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells: in mice the expression of BACE1 is high in the postnatal stages, when myelination occurs.

絞しぼり込こみシグナル伝達でんたつ経路けいろ神経しんけい科学かがくBACE

Auraptene
T4115495-02-3
Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities. It inhibits leukocyte activation and induces phas
- ￥7,000
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DSS30
T61439883027-32-5在庫ざいこ
DSS30 is a P25/CDK5 inhibitor.DSS30 acts by inhibiting the phosphorylation of amyloid precursor protein cleaving enzyme 1 (BACEl), which reduces the secretion of βべーた-amyloid (Aβべーた).DSS30 can be used for the prevention and treatment of neurodegenerative diseases such as Alzheimer's disease.
- ￥80,500
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Phytic acid potassium
T5075129832-03-7
Phytic acid dipotassium salt is an endogenous metabolite that inhibits βべーた-secretase 1 (BACE1).
- ￥9,500
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SEW06622
T83616261349-28-4
SEW06622 is a potent inhibitor of acetylcholinesterase (AChE) and beta-secretase-1 (BACE-1) and is a potential candidate for the treatment of Alzheimer's disease.
- ￥45,000
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BACE-IN-1 acetate
T3161L
BACE-IN-1 acetate (BACE-IN-1 acetate (350228-37-4，Free base)) has been used as βべーた-site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) inhibitor in BACE1 inhibitor assay. βべーた-Site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1), an aspartic protease belongs to the protease family of enzymes comprises of six luminal cysteine residues. These residues help in the formation of three intermolecular disulfide bonds and N-linked glycosylation sites.
- ￥34,000
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Atabecestat
T143381200493-78-2在庫ざいこ
Atabecestat (JNJ-54861911) is a potent, brain-penetrant, and orally active βべーた-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor that achieves robust and high CSF Aβべーた reduction, is well-tolerated, and displays sustained pharmacokinetic (PK) and pharmacodynamic (PD) characteristics. Atabecestat (JNJ-54861911) has the potential for Alzheimer's Disease treatment[1].
- ￥30,500
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Loganin
T275918524-94-2
Loganin (Loganoside), an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-αあるふぁ formation. This compound also has displayed potent free-radical-scavenging activity and inhibitory effects on melanogenesis.
- ￥9,500
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使用しよう例れい
AZD3839 free base
T67721227163-84-9
AZD3839 free base is a potent and selective BACE1 inhibitor with a Ki of 26.1 nM, demonstrating approximately 14-fold selectivity over BACE2. [Phase 1]
- ￥11,000
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Verubecestat
T70111286770-55-5
Verubecestat (MK-8931) (MK-8931) is an effective and specific βべーた-secretase inhibitor and βべーた-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.
- ￥8,000
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LY2886721
T60581262036-50-9
LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.
- ￥7,500
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LX2343
T4398333745-53-2
LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μみゅーM and acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μみゅーM. Additionally, LX2343 stimulates autophagy, promoting Aβべーた clearance.
- ￥8,500
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Aloeresin D
T8179105317-67-7
Aloeresin D, a natural chromone glycoside, inhibits βべーた-Secretase (BACE1) activity (IC50: 39 μみゅーM).
- ￥13,000
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Isorubrofusarin-6-O-βべーた-gentiobioside
TN1799200127-93-1
Isorubrofusarin-6-O-βべーた-gentiobioside is derived from from Cassia obtusifolia Linn seeds and shows promising inhibitory activity against AChE and BACE1.
- ￥51,000
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AM-6494
T102921874232-80-0
AM-6494, a potent and orally active BACE1 inhibitor (IC50: 0.4 nM), exhibits in vivo selectivity over BACE2 (IC50: 18.6 nM).
- ￥900,000
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BACE1-IN-1
T104501310347-50-2
BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).
- ￥379,000
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Anatabine
TN3410581-49-7
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheimer's disease effects, it inhibits BACE-1 transcription and reduces BACE-1 protein levels in hum
- ￥133,000
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Sophoflavescenol
TN2217216450-65-6
Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , these effects might contribute to the antitumor activity without severe side effects. Sophoflaves
- ￥151,000
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Lanabecestat
TQ02381383982-64-6
Lanabecestat (AZD3293) is a highly potent and highly permeable, orally active BACE1 inhibitor (Ki: 0.4 nM) that crosses the blood-brain barrier.Lanabecestat can be used for the study of neurological diseases such as Alzheimer's disease.
- ￥34,500
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Questin
TN21313774-64-9
Questin is an antimicrobial agent derived from Aspergillus florescens with an antimicrobial activity profile that inhibits V. harveyi, V. anguillarum, V. cholerae and V. parahemolyticus with MIC values of 31.25 µg/mL, 62.5 µg/mL, 62.5 µg/mL and 125 µg/mL, respectively. Questin has good potential to inhibit AChE, BChE and BACE1 and may be used in the development of drugs for the treatment or prevention of Alzheimer's disease.
- ￥186,500
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Epiberberine
T5S23616873-09-2
1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/ERK1/2 and AMPKαあるふぁ/Akt pathways during 3T3-L1 adipocyte differentiation. 3. Epiberberine, as the brightest FSA emitter among the alkaloids, can also serve as an efficient conformation probe for HTG DNA and discriminate the DNA G-quadruplex from the RNA counterpart.
- ￥7,500
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Epiberberine chloride
T8306889665-86-5
Epiberberine chloride, a natural pro-berberine from Coptis chinensis Franch. is an AChE, BChE, and BACE1 inhibitor with IC50 values of 1.07, 6.03, and 8.55 μみゅーM, respectively.Epiberberine chloride has antioxidant effects and inhibits the effects of Ca9-22 and Fa2R. Epiberberine chloride has antioxidant effects, inhibits the motility of Ca9-22 and FaDu cell lines, and can be used to study hyperlipidemia, Alzheimer's disease and diabetes.
- ￥7,500
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Putraflavone
TN486523624-21-7
Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
- ￥450,000
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Cassiaside
TN147213709-03-0
Cassiaside is a naphthyl ketone glycoside that inhibits BACE1 (IC50= 4.45 μみゅーM; Ki=9.85 μみゅーM).Cassiaside exhibits significant hepatoprotective effects against galactosamine injury and has potential anti-Alzheimer's disease (AD) activity.
- ￥19,500
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7-O-Methylaloeresin A
TN1332329361-25-3
7-O-Methylaloeresin A shows significant antioxidant activity, it also has moderate inhibitory active on BACE.
- ￥66,500
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BACE1-IN-4
T104522361157-92-6
BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), exhibiting greater selectivity for BACE1 over BACE2.
- ￥659,000
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PF-06751979
T124291818339-66-0
- ￥282,500
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Timosaponin BII
T3394136656-07-0
Timosaponin BII (Prototimosaponin A III) exhibits anti-dementia and antioxidant activities, with potential applications in treating type 2 diabetes. It can inhibit the up-regulation of BACE1 and reduce the over-production of βべーた-CTF and Aβべーた in rat retina induced by FeCl.
- ￥7,000
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Scoulerine
TN21906451-73-6
Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.
- ￥10,000
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LY2811376
T26391194044-20-6
LY2811376, an orally available non-peptidic βべーた-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβべーた secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including pepsin, cathepsin D, or renin.
- ￥11,000
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BACE1-IN-5
T104532581114-83-0
BACE1-IN-5 (Compound 15), a potent βべーた-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, demonstrates significant efficacy with an IC50 of 9.1 nM for BACE1 inhibition and an impressive IC50 of 0.82 nM against cellular amyloid-βべーた (Aβべーた) production. Additionally, it is engineered to enhance hERG inhibition and P-gp efflux, indicating its optimized medicinal chemistry profile [1].
- ￥349,000
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Kushenol C
TN439999119-73-0
Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2). Kushenol C shows antimicrobial activity against Staphylococcus aureus and Streptococcus mutan
- ￥305,000
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Umibecestat
T132531387560-01-1
Umibecestat is an inhibitor of beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1), with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. Umibecestat can be used for the research of alzheimer's disease.
- ￥40,500
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8-Geranyloxypsoralen
TN13437437-55-0
8-Geranyloxypsoralen inhibits αあるふぁ2-secretase (BACE1) activity in non-competitive manner, with the IC(50) values <25.0 μM, it can induce vasorelaxation on rat arterial tissues. 8-Geranyloxypsoralen possesses nematicidal activities, the median lethal concentrations (LC(50)) is 188.3 mg L against B. xylophilus and is 117.5 mg L against P. redivivus.
- ￥36,000
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BACE1-IN-2
T104511352416-78-4
- ￥590,000
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Elenbecestat
T111751388651-30-6
Elenbecestat (E2609) is an effective oral bioutilization and CNS penetrating ACE-1 inhibitor for the treatment of Alzheimer's disease.
- ￥15,000
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NB-360
T121881262857-73-7
- ￥26,000
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