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DNAATM/ATR
ATM serine/threonine kinase, symbol ATM, is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks. It phosphorylates several key proteins that initiate activation of the DNA damage checkpoint, leading to cell cycle arrest, DNA repair or apoptosis. Several of these targets, including p53, CHK2, BRCA1, NBS1 and H2AX are tumor suppressors. ATR is a serine/threonine kinase and belongs to the phosphoinositide 3- kinase related protein kinases (PIKKs), particularly to ATM (ataxia telangiectasia mutated) subfamily. It functions to maintain genome integrity by stabilizing replication forks and by regulating cell cycle progression and DNA repair.
- CamonsertibT620832417489-10-0Camonsertib (RP-3500) is a selective, orally active ATR kinase inhibitor (ATRi) with an IC50: 1.00 nM in biochemical assays and exhibits potent antitumour effects. Camonsertib is 30 times more selective for ATR than mTOR (IC50: 120 nM) and is a more active inhibitor of ATM, DNA-PK and PI3K
α kinases. PK and PI3Kα kinases.- ￥39,500
在庫 ありSizeQTY
- GartisertibT104071613191-99-3
在庫 ATR inhibitor 2 is an orally active, ATP-competitive, and selective ATR inhibitor (Ki <150 pM) with antitumor activity. ATR inhibitor 2 potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation (IC50: 8 nM).- ￥275,500
SizeQTY - Ro 90-7501T16773293762-45-5
在庫 Ro 90-7501 is an amyloidβ 42 (Aβ 42) protofibrillar and TPR-dependent PP5 inhibitor, a novel radiosensitizer for cervical cancer cells, which inhibits ATM phosphorylation, promotes apoptosis, and induces cell-cycle arrest. Ro 90-7501 also exhibits antiviral activity and potential anticancer activity by inhibiting ATM phosphorylation and DNA repair, and by inhibiting HCMV.- ￥7,000
在庫 ありSizeQTY - AZ31T196712088113-98-6
在庫 AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM, respectively.AZ31 exhibits excellent ATR selectivity, PIKK family selectivity, and pan-kinase selectivity.AZ31 is a potent in vitro radiosensitizer that can be used for cancer research.- ￥10,500
在庫 ありSizeQTY - KU60019T2474925701-49-1
在庫 Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50: 6.3 nM). It is much less effective or without effect against a panel of 229 other kinases.- ￥11,000
在庫 ありSizeQTY
使用 例 - AZ32T44432288709-96-4AZ32 is an orally bioavailable, blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for the ATM enzyme and an IC50 of 0.31 μM for ATM in cells.
- ￥12,000
在庫 ありSizeQTY
使用 例 - VE-821T30321232410-49-9VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki IC50: 13 26 nM in cell-free assays).
- ￥7,000
在庫 ありSizeQTY 使用 例 - WortmanninT628319545-26-7Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible. Wortmannin is also an inhibitor of PlK1 and PlK3 (IC50=5.8/48 nM) that blocks autophagy.
- ￥7,500
在庫 ありSizeQTY 使用 例 - DactolisibT2235915019-65-7Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR, with IC50 values of 4 nM for p110
α , 5 nM for p110γ , 7 nM for p110δ , 75 nM for p110β , and 20.7 nM for mTOR.- ￥9,000
在庫 ありSizeQTY 使用 例 - Torin 2T61001223001-51-1Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic properties. The EC50 of Torin 2 for ATM/ATR/DNA-PK inhibition is 28 nM/35 nM/118 nM, respectively.
- ￥8,000
在庫 ありSizeQTY 使用 例 - AZD0156T67701821428-35-6AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.
- ￥7,500
在庫 ありSizeQTY 使用 例 - CeralasertibT33381352226-88-0Ceralasertib (AZD6738) is an orally active, selective ATR kinase inhibitor with an IC50 of 1 nM.
- ￥10,000
在庫 ありSizeQTY 使用 例 - KU-55933T2685587871-26-9KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.
- ￥10,000
在庫 ありSizeQTY 使用 例 - NU6027T6612220036-08-8NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5
μ M/1.3μ M, 0.4μ M and 2.2μ M, enter cells more readily than the 6-aminopurine-based inhibitors.- ￥9,000
在庫 ありSizeQTY - CP-466722T62611080622-86-1CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells.
- ￥7,000
在庫 ありSizeQTY - GJ103 sodium saltT42511459687-96-7GJ103 sodium salt is an active analog of GJ072, a read-through compound. It has been shown to reduce the surface tension of aqueous solutions, which makes it easier for molecules to move through the solution. It has also been shown to reduce the viscosity of aqueous solutions, which makes it easier for molecules to move through the solution. Additionally, it has been shown to reduce the pH of aqueous solutions, which can have a variety of effects on the biochemical and physiological processes of living organisms.
- ￥10,000
在庫 ありSizeQTY - ElimusertibT73181876467-74-1Elimusertib (BAY-1895344) is a potent, highly selective, and orally available ATR inhibitor with an IC50 of 7 nM, demonstrating significant anti-tumor efficacy as a monotherapy and strong combination potential with targeted alpha therapy Radium-223 dichloride.
- ￥7,500
在庫 ありSizeQTY - PIK-93T2616593960-11-3PIK-93, the first potent synthetic PI4K inhibitor, exhibits an IC50 of 19 nM and also inhibits PI3K
α with an IC50 of 39 nM.- ￥8,500
在庫 ありSizeQTY - NU 7026T2433154447-35-5NU 7026 (DNA-PK Inhibitor II) is an effective DNA-PK inhibitor (IC50: 0.23
μ M, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition against both ATM and ATR.- ￥7,500
在庫 ありSizeQTY - BerzosertibT26691232416-25-9Berzosertib (VE-822) is an ATR inhibitor (Ki<0.2 nM) that also inhibits ATM (Ki=34 nM). Berzosertib has antitumor activity and has been used in trials investigating the treatment of ovarian tumors, plasmacytoid tumors of the ovary, solid tumors in adults, advanced solid tumors, and advanced solid tumors.
- ￥7,000
在庫 ありSizeQTY - Schisandrin BT292561281-37-6Schisandrin B (Schisandrin B (Sch B)) has an antioxidant effect on rodent liver and heart.
- ￥8,000
在庫 ありSizeQTY - ETP-46464T20841345675-02-6ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).
- ￥8,000
在庫 ありSizeQTY - AZ20T19581233339-22-4AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.
- ￥7,500
在庫 ありSizeQTY - ATR-IN-22T790332905312-07-2ATR-IN-22 (Compound 34), an orally active ATR inhibitor, exhibits potent anti-proliferative effects on MIAPaCa-2 cells with an IC50 value of less than 1
μ M and demonstrates anti-tumor activity in colon cancer [1].価格 を問合 せる
SizeQTY - ATR-IN-21T790312905312-17-4ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].
価格 を問合 せる
SizeQTY - ATM Inhibitor-8T79305ATM Inhibitor-8 (Compound 10r) is a potent, selective, and orally active ATM inhibitor with anti-tumor activity, characterized by an IC50 value of 1.15 nM [1].
価格 を問合 せる
SizeQTY - A011T78711A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycle arrest when combined with CPT-11, displaying notable antitumor activity [1].
- ￥33,000
約 35 daysSizeQTY - ATR-IN-24T790582370889-43-1ATR-IN-24 (Compound 1) is an ATR inhibitor exhibiting anticancer activity [1].
- ￥349,000
SizeQTY - CGK733T1821905973-89-9CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.
- ￥7,000
在庫 ありSizeQTY - Garcinone CTN167376996-27-5Garcinone C is a xanthone derivative extracted from Garcinia oblongifolia Champ with anti-inflammatory, astringency, and granulation-promoting activities. Garcinone C is an AChE inhibitor and has potential cytotoxic effects on certain cancers.
- ￥9,000
在庫 ありSizeQTY - LartesertibT626842495096-26-7Lartesertib (ATM Inhibitor-5) is an inhibitor of serine/threonine protein kinase ATM with potential anticancer activity for the study of lung cancer.
- ￥30,500
在庫 ありSizeQTY - ATR-IN-29T791212761193-67-1ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].
価格 を問合 せる
SizeQTY - ATM Inhibitor-9T79306ATM Inhibitor-9 (Compd 7a) is a potent ATM kinase inhibitor with an IC50 of 5 nM, used in cancer research [1].
価格 を問合 せる
SizeQTY - TuvusertibT104061613200-51-3Tuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 µΜ) with selective and potentially antitumor activity.Tuvusertib selectively inhibits ATR activity and blocks downstream phosphorylation of serine/threonine protein kinase checkpoint kinase 1 (CHK1), thereby inhibits DNA damage checkpoint activation, disrupting DNA damage repair and inducing apoptosis in tumor cells.
- ￥16,000
在庫 ありSizeQTY - (Z)-MirinT31341198097-97-0(Z)-Mirin is a potent Mre11–Rad50–Nbs1 (MRN) complex inhibitor, and inhibits Mre11-associated exonuclease activity.
- ￥11,500
在庫 ありSizeQTY - M3541T708731360628-91-6M3541 is a selectively potent and orally active ATM inhibitor with potential antitumor activity.M-3541 inhibits ATM kinase activity and ATM-mediated signaling by binding to ATM.M3541 prevents activation of DNA damage checkpoints, inhibits DNA damage repair, contributes to apoptosis, and induces death of ATM overexpressing tumor cells.
- ￥119,000
在庫 ありSizeQTY - KU-60019T63872925701-46-8KU-60019 is a specific inhibitor of ATM kinase (IC50: 6.3 nM).
- ￥7,500
在庫 ありSizeQTY - Elimusertib hydrochloride(1876467-74-1 free base)T10468Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumor activity.
- ￥12,000
在庫 ありSizeQTY - azd1390T51752089288-03-7AZD1390 is an exceptionally potent inhibitor of ATM in cells (IC50: 0.78 nM) with >10,000-fold selectivity over closely related members of the PIKK family of enzymes.
- ￥18,500
在庫 ありSizeQTY - ATR-IN-23T789592923800-62-6ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces synthetic lethality in HT-29 cells, suggesting its utility in researching DNA damage response (DDR)-deficient cancers [1].
- ￥349,000
SizeQTY - ATM Inhibitor-1T103962135639-94-8ATM Inhibitor-1 is a highly potent, selective, and orally active ATM inhibitor (IC50: 0.7 nM) with anti-tumor activity. It exhibits weak activity against mTOR (IC50, 21
μ M), DNAPK (IC50, 2.8μ M), PI3Kα (IC50, 3.8μ M), PI3Kβ (IC50, 10.3μ M), PI3Kγ (IC50, 3μ M), and PI3Kδ (IC50, 0.73μ M).- ￥555,500
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