炔诺酮

**炔诺酮**
臨床りんしょう資料しりょう
商品しょうひん名めい（英えい语：Drug nomenclature）	Alone: Aygestin, Camila, Heather, Micronor, Primolut N, others; With EE: Lo Loestrin, Loestrin, Microgestin, Modicon, Norinyl, Ortho-Novum, others; With E2: Activella, Activelle, Estalis, Kliogest, Necon, Novofem, Trisequens, others
其他名稱めいしょう	NET; Norethindrone; NSC-9564; LG-202; Ethinylnortestosterone; Norpregneninolone; Anhydrohydroxy-norprogesterone; Ethinylestrenolone; 17αあるふぁ-Ethynyl-19-nortestosterone; 17αあるふぁ-Ethynylestra-4-en-17βべーた-ol-3-one; 17αあるふぁ-Hydroxy-19-norpregn-4-en-20-yn-3-one
AHFS/Drugs.com	国くに际药品ひん名称めいしょう
MedlinePlus	a604034
给药途と径みち	By mouth, intramuscular injection (as NETE)
藥物やくぶつ類別るいべつ（英えい语：Drug class）	Progestin; Progestogen
ATC碼	G03AC01 (WHO) G03DC02;
藥物やくぶつ動力どうりょく學がく數かず據よりどころ
生物せいぶつ利用りよう度ど	47–73% (mean 64%)
血漿けっしょう蛋白たんぱく結合けつごう率りつ	97%:; Albumin: 61%;; SHBG: 36%
药物代だい谢	Mainly CYP3A4 (liver); also 5αあるふぁ-/5βべーた-reductase, 3αあるふぁ-/3βべーた-HSD, and aromatase
生物せいぶつ半はん衰おとろえ期き	5.2–12.8 hours (mean 8.0 hours)
识别信しん息いき
	IUPAC命名めいめい法ほう (8R,9S,10R,13S,14S,17R)-17-ethynyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one; ;
CAS号ごう	68-22-4
PubChem CID	6230;
IUPHAR/BPS	2880;
DrugBank	DB00717 ;
ChemSpider	5994 ;
UNII	T18F433X4S;
KEGG	D00182 ;
ChEBI	CHEBI:7627 ;
ChEMBL	ChEMBL1162 ;
CompTox Dashboard（英えい语：CompTox Chemicals Dashboard） (EPA)	DTXSID9023380 ;
ECHA InfoCard	100.000.619
化学かがく信しん息いき
化学かがく式しき	C20H26O2
摩ま尔质量りょう	298.419 g/mol
3D模型もけい（JSmol（英えい语：JSmol））	交互こうご式しき图像;
熔点	203至いたり204 °C（397至いたり399 °F）
	SMILES C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=CC(=O)CC[C@H]34;
	InChI InChI=1S/C20H26O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,12,15-18,22H,4-11H2,2H3/t15-,16+,17+,18-,19-,20-/m0/s1 ; Key:VIKNJXKGJWUCNN-XGXHKTLJSA-N ;

炔诺酮（英語えいご：Norethisterone 或ある英語えいご：norethindrone）是ぜ一いち种黄体おうたい制せい剂药物，用よう做口くち服ふく避孕药和わ激げき素もと替がえ代だい療法りょうほう药物以及治ち疗一些妇科疾病しっぺい^[4]。

参考さんこう文献ぶんけん[编辑]

^ ^1.0 ^1.1 Stanczyk, Frank Z. Pharmacokinetics and Potency of Progestins used for Hormone Replacement Therapy and Contraception (PDF). Reviews in Endocrine and Metabolic Disorders. Sep 2002, 3 (3): 211–224. ISSN 1389-9155. PMID 12215716. doi:10.1023/A:1020072325818.
^ Fotherby K. Bioavailability of orally administered sex steroids used in oral contraception and hormone replacement therapy. Contraception. August 1996, 54 (2): 59–69. PMID 8842581. doi:10.1016/0010-7824(96)00136-9.
^ Korhonen T, Turpeinen M, Tolonen A, Laine K, Pelkonen O. Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone. J. Steroid Biochem. Mol. Biol. 2008, 110 (1–2): 56–66. PMID 18356043. doi:10.1016/j.jsbmb.2007.09.025.
^ Kathryn Rhodes Alden; Deitra Leonard Lowdermilk; Mary Catherine Cashion; Shannon E. Perry. Maternity and Women's Health Care - E-Book. Elsevier Health Sciences. 27 December 2013: 135– [2019-06-30]. ISBN 978-0-323-29368-6. （原始げんし内容ないよう存そん档于2020-01-04）.

[pmid12215716-1] 1.0 ^1.1 Stanczyk, Frank Z. Pharmacokinetics and Potency of Progestins used for Hormone Replacement Therapy and Contraception (PDF). Reviews in Endocrine and Metabolic Disorders. Sep 2002, 3 (3): 211–224. ISSN 1389-9155. PMID 12215716. doi:10.1023/A:1020072325818.

[pmid8842581-2] Fotherby K. Bioavailability of orally administered sex steroids used in oral contraception and hormone replacement therapy. Contraception. August 1996, 54 (2): 59–69. PMID 8842581. doi:10.1016/0010-7824(96)00136-9.

[pmid18356043-3] Korhonen T, Turpeinen M, Tolonen A, Laine K, Pelkonen O. Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone. J. Steroid Biochem. Mol. Biol. 2008, 110 (1–2): 56–66. PMID 18356043. doi:10.1016/j.jsbmb.2007.09.025.

[AldenLowdermilk2013-4] Kathryn Rhodes Alden; Deitra Leonard Lowdermilk; Mary Catherine Cashion; Shannon E. Perry. Maternity and Women's Health Care - E-Book. Elsevier Health Sciences. 27 December 2013: 135– [2019-06-30]. ISBN 978-0-323-29368-6. （原始げんし内容ないよう存そん档于2020-01-04）.

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