膽きも囊收縮しゅうしゅく素もと

膽きも囊收縮しゅうしゅく素もと
識別しきべつ號ごう
别名	CCK；, cholecystokinin
外部がいぶID	OMIM：118440 MGI：88297 HomoloGene：583 GeneCards：CCK
基もと因いん位置いち（人ひと类）
染色せんしょく体たい	3號ごう染色せんしょく體たい
终止	42,266,185 bp
基もと因いん位置いち（小しょう鼠ねずみ）
染色せんしょく体たい	小しょう鼠ねずみ9号ごう染色せんしょく体たい
终止	121,324,760 bp
RNA表ひょう达模も式しき
	查阅更さら多た表ひょう达数据すえ
基もと因いん本體ほんたい
分子ぶんし功こう能のう	• hormone activity; • 血ち浆蛋白しろ结合; • neuropeptide hormone activity; • peptide hormone receptor binding;
細胞さいぼう組ぐみ分ぶん	• 細胞さいぼう本體ほんたい; • 細胞さいぼう外がい區域くいき; • 末梢まっしょう神經しんけい; • neuronal cell body; • 树突; • 轴丘; • axon initial segment; • 細胞さいぼう外がい空間くうかん; • 轴突;
生物せいぶつ學がく過程かてい	• regulation of sensory perception of pain; • eating behavior; • behavioral fear response; • negative regulation of appetite; • protein kinase C-activating G protein-coupled receptor signaling pathway; • positive regulation of mitochondrial depolarization; • positive regulation of glutamate secretion; • positive regulation of cell population proliferation; • positive regulation of protein oligomerization; • positive regulation of peptidyl-tyrosine phosphorylation; • positive regulation of apoptotic process; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • 訊息傳でん遞; • release of cytochrome c from mitochondria; • 细胞凋亡; • neuron migration; • axonogenesis; • regulation of signaling receptor activity; • G protein-coupled receptor signaling pathway; • 記憶きおく; • visual learning; • negative regulation of eating behavior; • positive regulation of sensory perception of pain; • negative regulation of behavioral fear response; • positive regulation of behavioral fear response; • 消化しょうか作用さよう;
	Sources:Amigo / QuickGO
直系ちょっけい同どう源みなもと
	885
	12424
	ENSG00000187094
	ENSMUSG00000032532
	P06307
	P09240
	NM_000729; NM_001174138
	NM_031161; NM_001284508
	NP_000720; NP_001167609
	NP_001271437; NP_112438
	維基數すう據よりどころ
檢視けんし/編輯へんしゅう人類じんるい	檢視けんし/編輯へんしゅう小しょう鼠ねずみ

膽きも囊收縮しゅうしゅく素もと（英語えいご：cholecystokinin，簡稱CCK或あるCCK-PZ）是ぜ一いち种脑肠肽，主要しゅよう功こう能のう是ぜ促进脂肪しぼう和わ蛋白たんぱく质的てき消化しょうか。其名称めいしょう源げん自じ希まれ腊语，包含ほうがんchole（胆汁たんじゅう）、cysto（囊状）和かずkinin（移うつり动）三さん个部分ぶぶん，整体せいたい意い为“移うつり动胆汁じる之の囊”。它不仅在消化しょうか系けい统中ちゅう广泛存在そんざい，还在中枢ちゅうすう及外周がいしゅう神しん经系统中发挥作用さよう^[5]。

膽きも囊收縮しゅうしゅく素もと在ざい此之前まえ名めい為ため促胰酶素（pancreozymin），是ぜ由ゆかり小腸しょうちょう的てき黏膜上皮じょうひ細胞さいぼう當とう中なか的てきI細胞さいぼう所ところ合成ごうせい，並なみ由ゆかり十二指腸じゅうにしちょう分泌ぶんぴつ。当とう胆きも囊收缩素被ひ分泌ぶんぴつ出来でき后きさき，会かい刺激しげき胰脏和わ胆きも囊分ぶん别释放消化しょうか酶和わ胆汁たんじゅう，以帮助じょ消化しょうか过程。

除じょ了りょう在ざい消化しょうか过程中ちゅう发挥作用さよう，胆きも囊收缩素还是一种食欲抑制剂。当とう胆きも囊收缩素在ざい体内たいない水平すいへい升ます高だか时，可か以抑制よくせい食欲しょくよく，帮助控ひかえ制せい食物しょくもつ的てき摄入量りょう。最近さいきん的てき證據しょうこ暗示あんじ，膽きも囊收縮しゅうしゅく素もと在ざい促進そくしん鴉片あへん類るい藥物やくぶつ的てき藥物やくぶつ容よう許もと量りょう，如嗎啡和わ海うみ洛らく因いん，扮ふん演えんじ著しる重要じゅうよう角かく色しょく，並なみ且在經歷けいれき鴉片あへん類るい藥物やくぶつ停とま藥くすり後こう的てき疼痛とうつう過敏かびん經歷けいれき有ゆう著ちょ部ぶ份的關聯かんれん性せい^[6]^[7]。

膽きも囊收縮しゅうしゅく素もと基もと因いん最早もはや在ざい狗いぬ（Canis lupus familiaris）的てき胃い肠道中ちゅう被ひ发现^[8]，随ずい后きさき在ざい人ひと类（Homo sapiens）、小しょう鼠ねずみ（Mus musculus）、虹にじ鳟（Oncorhynchus mykiss）、大西洋たいせいよう鲑（Salmo salar）和わ团头鲂（Megalobrama amblycephala）等とう多た个物种中也有やゆう发现^[5]。研究けんきゅう表明ひょうめい，不同ふどう动物中ちゅう的てき膽きも囊收縮しゅうしゅく素もと存在そんざい两种甚至三种不同的亚型，并且它们的てき功こう能のう存在そんざい差さ异^[5]。例れい如，在ざい虹にじ鳟中存在そんざいCCK-L、CCK-N和わCCK-T三种膽囊收縮素亚型，其中CCK-L亚型作さく为饱腹はら因子いんし调节摄食，而CCK-N亚型则无显著作用さよう^[9]。在ざい红鲷（Pagrus major）中ちゅう发现CCK基もと因いん存在そんざいCCK1和わCCK2亚型，其中CCK1亚型在ざい消化しょうか过程中ちゅう发挥重要じゅうよう作用さよう，CCK2亚型则通过向脑发送信そうしん号ごう调节食物しょくもつ摄入和わ控ひかえ制せい饱腹感かん^[10]。而在白しろ鲷（Diplodus sargus）中ちゅう，CCK1基き因いん的てき表ひょう达水平すいへい不ふ受摄食しょく影かげ响，CCK2基き因いん则参与さんよ消化しょうか过程的てき负反馈调节^[11]。

膽きも囊收縮しゅうしゅく素もと基もと因いん通どおり过与胆きも囊收缩素受体基もと因いん（Cholecystokinin receptor，简称CCKR）相あい结合，调节动物的てき摄食、消化しょうか等とう生理せいり过程^[12]。在ざい多数たすう动物中ちゅう，CCKR基もと因いん存在そんざいCCK1R和わCCK2R两种亚型^[13]。研究けんきゅう显示，CCK与あずかCCK1R基もと因いん结合主要しゅよう影かげ响消化しょうか系けい统，而CCK与あずかCCK2R基もと因いん结合则主要よう影かげ响中枢ちゅうすう神しん经系统，二者共同参与摄食活动的调节过程^[14]。

參考さんこう文獻ぶんけん[编辑]

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000187094 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000032532 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^5.0 ^5.1 ^5.2 禁きん食しょく和わ复投喂对大口おおぐち黑くろ鲈胆囊收缩素及其受体基もと因いん表ひょう达的影かげ响. 水生すいせい生物せいぶつ学がく报. 2023-08-15, 47 (8): 1220–1227. doi:10.7541/2023.2022.0175.
^ Kissin I, Bright CA, Bradley EL. Acute tolerance to continuously infused alfentanil: the role of cholecystokinin and N-methyl-D-aspartate-nitric oxide systems. Anesth. Analg. 2000, 91 (1): 110–6 [2013-12-02]. PMID 10866896. doi:10.1097/00000539-200007000-00021. （原始げんし内容ないよう存そん档于2007-12-06）.
^ Fukazawa Y, Maeda T, Kiguchi N, Tohya K, Kimura M, Kishioka S. Activation of spinal cholecystokinin and neurokinin-1 receptors is associated with the attenuation of intrathecal morphine analgesia following electroacupuncture stimulation in rats. J. Pharmacol. Sci. 2007, 104 (2): 159–66. PMID 17558184. doi:10.1254/jphs.FP0070475.
^ Ivy, A. C.; Oldberg, E. Contraction and Evacuation of Gall-Bladder Caused by Highly Purified "Secretin" Preparation.. Experimental Biology and Medicine. 1927-11-01, 25 (2): 113–115. doi:10.3181/00379727-25-3724.
^ Jensen, H; Rourke, IJ; Møller, M; Jønson, L; Johnsen, AH. Identification and distribution of CCK-related peptides and mRNAs in the rainbow trout, Oncorhynchus mykiss.. Biochimica et biophysica acta. 2001-01-26, 1517 (2): 190–201. PMID 11342099. doi:10.1016/s0167-4781(00)00263-3.
^ Huong, Tran Thi Mai; Murashita, Koji; Senzui, Ayaka; Matsumoto, Toshiro; Fukada, Haruhisa. Cholecystokinin 1 and 2 in red seabream Pagrus major: molecular cloning, response to feeding, and a potential indicator of dietary protein source quality. Fisheries Science. 2020-09, 86 (5): 835–849. doi:10.1007/s12562-020-01443-z.
^ Micale, V; Campo, S; D'Ascola, A; Guerrera, MC; Levanti, MB; Germanà, A; Muglia, U. Cholecystokinin in white sea bream: molecular cloning, regional expression, and immunohistochemical localization in the gut after feeding and fasting.. PloS one. 2012, 7 (12): e52428. PMID 23285038. doi:10.1371/journal.pone.0052428.
^ Yu, N; Smagghe, G. CCK(-like) and receptors: structure and phylogeny in a comparative perspective.. General and comparative endocrinology. 2014-12-01, 209: 74–81. PMID 24842717. doi:10.1016/j.ygcen.2014.05.003.
^ Dufresne, M; Seva, C; Fourmy, D. Cholecystokinin and gastrin receptors.. Physiological reviews. 2006-07, 86 (3): 805–47. PMID 16816139. doi:10.1152/physrev.00014.2005.
^ Balaskó, M.; Rostás, I.; Füredi, N.; Mikó, A.; Tenk, J.; Cséplő, P.; Koncsecskó-Gáspár, M.; Soós, S.; Székely, M.; Pétervári, E. Age and nutritional state influence the effects of cholecystokinin on energy balance. Experimental Gerontology. 2013-11, 48 (11): 1180–1188. doi:10.1016/j.exger.2013.07.006.

外部がいぶ連結れんけつ[编辑]

醫學いがく主題しゅだい詞し表ひょう（MeSH）：Cholecystokinin

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000187094 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000032532 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[2022.0175-5] 5.0 ^5.1 ^5.2 禁きん食しょく和わ复投喂对大口おおぐち黑くろ鲈胆囊收缩素及其受体基もと因いん表ひょう达的影かげ响. 水生すいせい生物せいぶつ学がく报. 2023-08-15, 47 (8): 1220–1227. doi:10.7541/2023.2022.0175.

[pmid10866896-6] Kissin I, Bright CA, Bradley EL. Acute tolerance to continuously infused alfentanil: the role of cholecystokinin and N-methyl-D-aspartate-nitric oxide systems. Anesth. Analg. 2000, 91 (1): 110–6 [2013-12-02]. PMID 10866896. doi:10.1097/00000539-200007000-00021. （原始げんし内容ないよう存そん档于2007-12-06）.

[pmid17558184-7] Fukazawa Y, Maeda T, Kiguchi N, Tohya K, Kimura M, Kishioka S. Activation of spinal cholecystokinin and neurokinin-1 receptors is associated with the attenuation of intrathecal morphine analgesia following electroacupuncture stimulation in rats. J. Pharmacol. Sci. 2007, 104 (2): 159–66. PMID 17558184. doi:10.1254/jphs.FP0070475.

[8] Ivy, A. C.; Oldberg, E. Contraction and Evacuation of Gall-Bladder Caused by Highly Purified "Secretin" Preparation.. Experimental Biology and Medicine. 1927-11-01, 25 (2): 113–115. doi:10.3181/00379727-25-3724.

[9] Jensen, H; Rourke, IJ; Møller, M; Jønson, L; Johnsen, AH. Identification and distribution of CCK-related peptides and mRNAs in the rainbow trout, Oncorhynchus mykiss.. Biochimica et biophysica acta. 2001-01-26, 1517 (2): 190–201. PMID 11342099. doi:10.1016/s0167-4781(00)00263-3.

[10] Huong, Tran Thi Mai; Murashita, Koji; Senzui, Ayaka; Matsumoto, Toshiro; Fukada, Haruhisa. Cholecystokinin 1 and 2 in red seabream Pagrus major: molecular cloning, response to feeding, and a potential indicator of dietary protein source quality. Fisheries Science. 2020-09, 86 (5): 835–849. doi:10.1007/s12562-020-01443-z.

[11] Micale, V; Campo, S; D'Ascola, A; Guerrera, MC; Levanti, MB; Germanà, A; Muglia, U. Cholecystokinin in white sea bream: molecular cloning, regional expression, and immunohistochemical localization in the gut after feeding and fasting.. PloS one. 2012, 7 (12): e52428. PMID 23285038. doi:10.1371/journal.pone.0052428.

[12] Yu, N; Smagghe, G. CCK(-like) and receptors: structure and phylogeny in a comparative perspective.. General and comparative endocrinology. 2014-12-01, 209: 74–81. PMID 24842717. doi:10.1016/j.ygcen.2014.05.003.

[13] Dufresne, M; Seva, C; Fourmy, D. Cholecystokinin and gastrin receptors.. Physiological reviews. 2006-07, 86 (3): 805–47. PMID 16816139. doi:10.1152/physrev.00014.2005.

[14] Balaskó, M.; Rostás, I.; Füredi, N.; Mikó, A.; Tenk, J.; Cséplő, P.; Koncsecskó-Gáspár, M.; Soós, S.; Székely, M.; Pétervári, E. Age and nutritional state influence the effects of cholecystokinin on energy balance. Experimental Gerontology. 2013-11, 48 (11): 1180–1188. doi:10.1016/j.exger.2013.07.006.

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