CD29

CD29
已やめ知的ちてき結構けっこう
PDB	直系ちょっけい同どう源みなもと搜索そうさく: PDBe RCSB
PDBID列れつ表ひょう
	4WK4、3G9W、3T9K、3VI3、3VI4、4DX9、4WJK、4WK0、4WK2
識別しきべつ號ごう
别名	ITGB1；, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB, integrin subunit beta 1
外部がいぶID	OMIM：135630 MGI：96610 HomoloGene：22999 GeneCards：ITGB1
基もと因いん位置いち（人ひと类）
染色せんしょく体たい	10號ごう染色せんしょく體たい
终止	33,005,792 bp
基もと因いん位置いち（小しょう鼠ねずみ）
染色せんしょく体たい	小しょう鼠ねずみ8号ごう染色せんしょく体たい
终止	129,459,681 bp
RNA表ひょう达模も式しき
	查阅更さら多た表ひょう达数据すえ
基もと因いん本體ほんたい
分子ぶんし功こう能のう	• virus receptor activity; • 金屬きんぞく離はなれ子こ結合けつごう; • integrin binding; • 血ち浆蛋白しろ结合; • laminin binding; • cell adhesion molecule binding; • collagen binding involved in cell-matrix adhesion; • coreceptor activity; • 蛋白たんぱく酶結合けつごう; • fibronectin binding; • actin binding; • C-X3-C chemokine binding; • protein heterodimerization activity; • 大分おおいた子こ复合物ぶつ结合; • cadherin binding; • signaling receptor activity;
細胞さいぼう組ぐみ分ぶん	• 細胞さいぼう質しつ; • 核かく内ない体からだ; • 膜まく; • 黑くろ色素しきそ体たい; • ruffle; • integrin alpha8-beta1 complex; • 突触; • ruffle membrane; • integrin complex; • 细胞质的核かく周しゅう区域くいき; • cell projection; • 树突棘とげ; • cell surface; • 分裂ぶんれつ沟; • integrin alpha7-beta1 complex; • 外そと排はい體たい; • 板いた状じょう伪足; • integral component of membrane; • recycling endosome; • integrin alpha1-beta1 complex; • 肌はだ間あいだ盤ばん; • 絲狀いとじょう偽足ぎそく; • 神かみ经肌肉にく接点せってん; • receptor complex; • 细胞膜まく; • integrin alpha11-beta1 complex; • myelin sheath abaxonal region; • synaptic membrane; • integrin alpha10-beta1 complex; • 细胞连接; • integrin alpha2-beta1 complex; • 肌はだ膜まく; • external side of plasma membrane; • cytoplasmic vesicle; • integrin alpha3-beta1 complex; • 脂あぶら筏いかだ模型もけい; • 粘着ねんちゃく斑まだら; • glial cell projection; • Schaffer collateral - CA1 synapse; • glutamatergic synapse; • integral component of synaptic membrane; • 大分おおいた子こ复合体がったい;
生物せいぶつ學がく過程かてい	• leukocyte cell-cell adhesion; • cell migration involved in sprouting angiogenesis; • stress fiber assembly; • 病毒びょうどく进入; • B cell differentiation; • neuron projection development; • transforming growth factor beta receptor signaling pathway; • regulation of collagen catabolic process; • negative regulation of cell differentiation; • cardiac muscle cell differentiation; • cellular response to low-density lipoprotein particle stimulus; • in utero embryonic development; • cell-substrate adhesion; • positive regulation of GTPase activity; • regulation of immune response; • viral process; • dendrite morphogenesis; • cell fate specification; • G1期き; • heterotypic cell-cell adhesion; • extracellular matrix organization; • cell-cell adhesion mediated by integrin; • cellular defense response; • 細胞さいぼう粘ねば附ふ; • formation of radial glial scaffolds; • axon extension; • leukocyte tethering or rolling; • integrin-mediated signaling pathway; • cell-matrix adhesion; • sarcomere organization; • negative regulation of anoikis; • leukocyte migration; • homophilic cell adhesion via plasma membrane adhesion molecules; • visual learning; • calcium-independent cell-matrix adhesion; • cardiac muscle tissue development; • negative regulation of Rho protein signal transduction; • receptor internalization; • regulation of cell cycle; • positive regulation of cell population proliferation; • positive regulation of apoptotic process; • mesodermal cell differentiation; • 细胞迁移; • germ cell migration; • cell adhesion mediated by integrin; • basement membrane organization; • positive regulation of protein localization to plasma membrane; • G1/S transition of mitotic cell cycle; • 吞噬作用さよう; • cytokine-mediated signaling pathway; • cell projection organization; • lamellipodium assembly; • positive regulation of angiogenesis; • modulation of chemical synaptic transmission; • positive regulation of protein kinase B signaling; • positive regulation of signaling receptor activity; • positive regulation of cell migration;
	Sources:Amigo / QuickGO
直系ちょっけい同どう源みなもと
	3688
	16412
	ENSG00000150093
	ENSMUSG00000025809
	P05556
	P09055
NM_002211; NM_033666; NM_033667; NM_033668; NM_033669;
	NM_133376
	NM_010578
	NP_002202; NP_391988; NP_596867
	NP_034708
	維基數すう據よりどころ
檢視けんし/編輯へんしゅう人類じんるい	檢視けんし/編輯へんしゅう小しょう鼠ねずみ

整せい联蛋白しろβべーた-1（英語えいご：Integrin beta-1），也被称しょう为 CD29 是ぜ一いち个由人じん类基もと因いん ITGB1 编码的てき蛋白たんぱく质^[5]。CD29是ぜ整合せいごう素もと极晚期き抗原こうげん受体的てき一いち个亚基もと。它与αあるふぁ-3亚基形成けいせい整合せいごう素もとαあるふぁ3β1，作さく为神かみ经生长因子いんし1和わ络丝蛋白たんぱく的てき受体。在ざい心こころ肌はだ和わ骨骼こっかく肌はだ种，整せい联蛋白しろβべーた-1会かい选择性せい表ひょう达为βべーた-1D蛋白たんぱく质异形体けいたい。

相互そうご作用さよう

CD29已やめ经显示しめせ出で与あずか下しも列れつ蛋白質たんぱくしつ交互こうご作用さよう：

参考さんこう文献ぶんけん

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000150093 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000025809 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Assignment of the gene encoding the beta-subunit of the human fibronectin receptor (beta-FNR) to chromosome 10p11.2. Annals of Human Genetics. Jan 1989, 53 (Pt 1): 15–22. PMID 2524991. doi:10.1111/j.1469-1809.1989.tb01118.x.
^ Otey CA, Pavalko FM, Burridge K. An interaction between alpha-actinin and the beta 1 integrin subunit in vitro. The Journal of Cell Biology. Aug 1990, 111 (2): 721–9. PMC 2116186 . PMID 2116421. doi:10.1083/jcb.111.2.721.
^ Otey CA, Vasquez GB, Burridge K, Erickson BW. Mapping of the alpha-actinin binding site within the beta 1 integrin cytoplasmic domain. The Journal of Biological Chemistry. Oct 1993, 268 (28): 21193–7. PMID 7691808.
^ Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E. CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans. European Journal of Immunology. Mar 2000, 30 (3): 900–7. PMID 10741407. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X.
^ Radford KJ, Thorne RF, Hersey P. CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma. Biochemical and Biophysical Research Communications. May 1996, 222 (1): 13–8. PMID 8630057. doi:10.1006/bbrc.1996.0690.
^ ^10.0 ^10.1 Mazzocca A, Carloni V, Sciammetta S, Cordella C, Pantaleo P, Caldini A, Gentilini P, Pinzani M. Expression of transmembrane 4 superfamily (TM4SF) proteins and their role in hepatic stellate cell motility and wound healing migration. Journal of Hepatology. Sep 2002, 37 (3): 322–30. PMID 12175627. doi:10.1016/S0168-8278(02)00175-7.
^ Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M. The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes. The Journal of Biological Chemistry. Oct 2000, 275 (43): 33669–78. PMID 10906324. doi:10.1074/jbc.M002519200.
^ ^12.0 ^12.1 van der Flier A, Kuikman I, Kramer D, Geerts D, Kreft M, Takafuta T, Shapiro SS, Sonnenberg A. Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits. The Journal of Cell Biology. Jan 2002, 156 (2): 361–76. PMC 2199218 . PMID 11807098. doi:10.1083/jcb.200103037.
^ Loo DT, Kanner SB, Aruffo A. Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interaction. The Journal of Biological Chemistry. Sep 1998, 273 (36): 23304–12. PMID 9722563. doi:10.1074/jbc.273.36.23304.
^ Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E. Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions. The Biochemical Journal. May 1999, 340 (Pt 1): 103–11. PMC 1220227 . PMID 10229664. doi:10.1042/0264-6021:3400103.
^ ^15.0 ^15.1 Lee HS, Millward-Sadler SJ, Wright MO, Nuki G, Al-Jamal R, Salter DM. Activation of Integrin-RACK1/PKCalpha signalling in human articular chondrocyte mechanotransduction. Osteoarthritis and Cartilage / OARS, Osteoarthritis Research Society. Nov 2002, 10 (11): 890–7. PMID 12435334. doi:10.1053/joca.2002.0842.
^ Liliental J, Chang DD. Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit. The Journal of Biological Chemistry. Jan 1998, 273 (4): 2379–83. PMID 9442085. doi:10.1074/jbc.273.4.2379.
^ Chang DD, Wong C, Smith H, Liu J. ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin. The Journal of Cell Biology. Sep 1997, 138 (5): 1149–57. PMC 2136751 . PMID 9281591. doi:10.1083/jcb.138.5.1149.
^ Chang DD, Hoang BQ, Liu J, Springer TA. Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin. The Journal of Biological Chemistry. Mar 2002, 277 (10): 8140–5. PMID 11741908. doi:10.1074/jbc.M109031200.
^ Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y. Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis. Journal of Cell Science. Jul 2000, 113 (13): 2385–97. PMID 10852818.
^ Poinat P, De Arcangelis A, Sookhareea S, Zhu X, Hedgecock EM, Labouesse M, Georges-Labouesse E. A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans. Current Biology. Apr 2002, 12 (8): 622–31. PMID 11967148. doi:10.1016/S0960-9822(02)00764-9.
^ Fournier HN, Dupé-Manet S, Bouvard D, Lacombe ML, Marie C, Block MR, Albiges-Rizo C. Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement. The Journal of Biological Chemistry. Jun 2002, 277 (23): 20895–902. PMID 11919189. doi:10.1074/jbc.M200200200.
^ Parsons M, Keppler MD, Kline A, Messent A, Humphries MJ, Gilchrist R, Hart IR, Quittau-Prevostel C, Hughes WE, Parker PJ, Ng T. Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis. Molecular and Cellular Biology. Aug 2002, 22 (16): 5897–911. PMC 133968 . PMID 12138200. doi:10.1128/MCB.22.16.5897-5911.2002.
^ Tapley P, Horwitz A, Buck C, Duggan K, Rohrschneider L. Integrins isolated from Rous sarcoma virus-transformed chicken embryo fibroblasts. Oncogene. Mar 1989, 4 (3): 325–33. PMID 2468126.
^ Horwitz A, Duggan K, Buck C, Beckerle MC, Burridge K. Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage. Nature. 1986, 320 (6062): 531–3. PMID 2938015. doi:10.1038/320531a0.
^ Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME. NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. The Journal of Biological Chemistry. Nov 1997, 272 (46): 29181–9. PMID 9360996. doi:10.1074/jbc.272.46.29181.
^ Han DC, Rodriguez LG, Guan JL. Identification of a novel interaction between integrin beta1 and 14-3-3beta. Oncogene. Jan 2001, 20 (3): 346–57. PMID 11313964. doi:10.1038/sj.onc.1204068.

外部がいぶ链接

醫學いがく主題しゅだい詞し表ひょう（MeSH）：CD29+Antigen
Human ITGB1 genome location and ITGB1 gene details page in the UCSC Genome Browser（英えい语：UCSC Genome Browser）.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000150093 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000025809 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2524991-5] Assignment of the gene encoding the beta-subunit of the human fibronectin receptor (beta-FNR) to chromosome 10p11.2. Annals of Human Genetics. Jan 1989, 53 (Pt 1): 15–22. PMID 2524991. doi:10.1111/j.1469-1809.1989.tb01118.x.

[6] Otey CA, Pavalko FM, Burridge K. An interaction between alpha-actinin and the beta 1 integrin subunit in vitro. The Journal of Cell Biology. Aug 1990, 111 (2): 721–9. PMC 2116186 . PMID 2116421. doi:10.1083/jcb.111.2.721.

[7] Otey CA, Vasquez GB, Burridge K, Erickson BW. Mapping of the alpha-actinin binding site within the beta 1 integrin cytoplasmic domain. The Journal of Biological Chemistry. Oct 1993, 268 (28): 21193–7. PMID 7691808.

[pmid10741407-8] Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E. CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans. European Journal of Immunology. Mar 2000, 30 (3): 900–7. PMID 10741407. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X.

[pmid8630057-9] Radford KJ, Thorne RF, Hersey P. CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma. Biochemical and Biophysical Research Communications. May 1996, 222 (1): 13–8. PMID 8630057. doi:10.1006/bbrc.1996.0690.

[pmid12175627-10] 10.0 ^10.1 Mazzocca A, Carloni V, Sciammetta S, Cordella C, Pantaleo P, Caldini A, Gentilini P, Pinzani M. Expression of transmembrane 4 superfamily (TM4SF) proteins and their role in hepatic stellate cell motility and wound healing migration. Journal of Hepatology. Sep 2002, 37 (3): 322–30. PMID 12175627. doi:10.1016/S0168-8278(02)00175-7.

[pmid10906324-11] Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M. The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes. The Journal of Biological Chemistry. Oct 2000, 275 (43): 33669–78. PMID 10906324. doi:10.1074/jbc.M002519200.

[pmid11807098-12] 12.0 ^12.1 van der Flier A, Kuikman I, Kramer D, Geerts D, Kreft M, Takafuta T, Shapiro SS, Sonnenberg A. Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits. The Journal of Cell Biology. Jan 2002, 156 (2): 361–76. PMC 2199218 . PMID 11807098. doi:10.1083/jcb.200103037.

[pmid9722563-13] Loo DT, Kanner SB, Aruffo A. Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interaction. The Journal of Biological Chemistry. Sep 1998, 273 (36): 23304–12. PMID 9722563. doi:10.1074/jbc.273.36.23304.

[pmid10229664-14] Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E. Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions. The Biochemical Journal. May 1999, 340 (Pt 1): 103–11. PMC 1220227 . PMID 10229664. doi:10.1042/0264-6021:3400103.

[pmid12435334-15] 15.0 ^15.1 Lee HS, Millward-Sadler SJ, Wright MO, Nuki G, Al-Jamal R, Salter DM. Activation of Integrin-RACK1/PKCalpha signalling in human articular chondrocyte mechanotransduction. Osteoarthritis and Cartilage / OARS, Osteoarthritis Research Society. Nov 2002, 10 (11): 890–7. PMID 12435334. doi:10.1053/joca.2002.0842.

[pmid9442085-16] Liliental J, Chang DD. Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit. The Journal of Biological Chemistry. Jan 1998, 273 (4): 2379–83. PMID 9442085. doi:10.1074/jbc.273.4.2379.

[pmid9281591-17] Chang DD, Wong C, Smith H, Liu J. ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin. The Journal of Cell Biology. Sep 1997, 138 (5): 1149–57. PMC 2136751 . PMID 9281591. doi:10.1083/jcb.138.5.1149.

[pmid11741908-18] Chang DD, Hoang BQ, Liu J, Springer TA. Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin. The Journal of Biological Chemistry. Mar 2002, 277 (10): 8140–5. PMID 11741908. doi:10.1074/jbc.M109031200.

[pmid10852818-19] Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y. Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis. Journal of Cell Science. Jul 2000, 113 (13): 2385–97. PMID 10852818.

[pmid11967148-20] Poinat P, De Arcangelis A, Sookhareea S, Zhu X, Hedgecock EM, Labouesse M, Georges-Labouesse E. A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans. Current Biology. Apr 2002, 12 (8): 622–31. PMID 11967148. doi:10.1016/S0960-9822(02)00764-9.

[pmid11919189-21] Fournier HN, Dupé-Manet S, Bouvard D, Lacombe ML, Marie C, Block MR, Albiges-Rizo C. Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement. The Journal of Biological Chemistry. Jun 2002, 277 (23): 20895–902. PMID 11919189. doi:10.1074/jbc.M200200200.

[pmid12138200-22] Parsons M, Keppler MD, Kline A, Messent A, Humphries MJ, Gilchrist R, Hart IR, Quittau-Prevostel C, Hughes WE, Parker PJ, Ng T. Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis. Molecular and Cellular Biology. Aug 2002, 22 (16): 5897–911. PMC 133968 . PMID 12138200. doi:10.1128/MCB.22.16.5897-5911.2002.

[23] Tapley P, Horwitz A, Buck C, Duggan K, Rohrschneider L. Integrins isolated from Rous sarcoma virus-transformed chicken embryo fibroblasts. Oncogene. Mar 1989, 4 (3): 325–33. PMID 2468126.

[24] Horwitz A, Duggan K, Buck C, Beckerle MC, Burridge K. Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage. Nature. 1986, 320 (6062): 531–3. PMID 2938015. doi:10.1038/320531a0.

[pmid9360996-25] Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME. NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. The Journal of Biological Chemistry. Nov 1997, 272 (46): 29181–9. PMID 9360996. doi:10.1074/jbc.272.46.29181.

[pmid11313964-26] Han DC, Rodriguez LG, Guan JL. Identification of a novel interaction between integrin beta1 and 14-3-3beta. Oncogene. Jan 2001, 20 (3): 346–57. PMID 11313964. doi:10.1038/sj.onc.1204068.

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