MYO5A

MYO5A
已やめ知的ちてき結構けっこう
PDB	直系ちょっけい同どう源みなもと搜索そうさく: PDBe RCSB
PDBID列れつ表ひょう
	4J5L、4LX1、4LX2、4LLI、4D07
識別しきべつ號ごう
别名	MYO5A；, GS1, MYH12, MYO5, MYR12, myosin VA
外部がいぶID	OMIM：160777 MGI：105976 HomoloGene：20100 GeneCards：MYO5A
基もと因いん位置いち（人ひと类）
染色せんしょく体たい	15號ごう染色せんしょく體たい
终止	52,529,132 bp
基もと因いん位置いち（小しょう鼠ねずみ）
染色せんしょく体たい	小しょう鼠ねずみ9号ごう染色せんしょく体たい
终止	75,130,970 bp
RNA表ひょう达模も式しき
	查阅更さら多た表ひょう达数据すえ
基もと因いん本體ほんたい
分子ぶんし功こう能のう	• calcium ion binding; • 核かく苷酸結合けつごう; • calmodulin binding; • microfilament motor activity; • actin binding; • cytoskeletal motor activity; • ATP結合けつごう; • RNA binding; • 无序域いき特とく异性结合; • 相あい同どう蛋白たんぱく质结合あい; • 血ち浆蛋白しろ结合; • actin filament binding;
細胞さいぼう組ぐみ分ぶん	• 細胞さいぼう質しつ; • recycling endosome; • 囊泡; • 细胞质基质; • 晚期ばんき内ない吞体; • 高こう尔基体きたい; • 膜まく; • 生なま长锥; • ruffle; • 黑くろ色素しきそ体たい; • insulin-responsive compartment; • photoreceptor outer segment; • 过氧化物ばけもの酶体; • secretory granule; • microtubule plus-end; • filopodium tip; • neuronal cell body; • 早期そうき内ない吞体; • 内うち质网; • 微ほろ丝; • neuron projection; • 溶酶体たい; • actomyosin; • 中ちゅう间纤维; • 外そと排はい體たい; • myosin complex; • unconventional myosin complex; • smooth endoplasmic reticulum; • postsynapse; • glutamatergic synapse;
生物せいぶつ學がく過程かてい	• regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; • melanin biosynthetic process; • synapse organization; • insulin secretion; • secretory granule localization; • melanosome localization; • actin filament-based movement; • post-Golgi vesicle-mediated transport; • odontogenesis; • endoplasmic reticulum localization; • melanin metabolic process; • regulation of Golgi organization; • long-chain fatty acid biosynthetic process; • melanosome transport; • cellular response to insulin stimulus; • vesicle transport along actin filament; • protein transport; • developmental pigmentation; • 髓ずい鞘さや形成けいせい; • 色素しきそ沉着; • protein localization to plasma membrane; • melanocyte differentiation; • locomotion involved in locomotory behavior; • vesicle-mediated transport; • 視覺しかく; • 胞吐作用さよう; • 化学かがく性せい突触传递; • hair follicle maturation; • transport; • establishment of endoplasmic reticulum localization to postsynapse; • regulation of postsynaptic cytosolic calcium ion concentration;
	Sources:Amigo / QuickGO
直系ちょっけい同どう源みなもと
	4644
	17918
	ENSG00000197535
	ENSMUSG00000034593
	Q9Y4I1
	Q99104
	NM_000259; NM_001142495; NM_001382347; NM_001382348; NM_001382349
	NM_010864
	NP_000250; NP_001135967; NP_001369276; NP_001369277; NP_001369278
	NP_034994
	維基數すう據よりどころ
檢視けんし/編輯へんしゅう人類じんるい	檢視けんし/編輯へんしゅう小しょう鼠ねずみ

MYO5A是ぜ一いち个位于人ひと类15号ごう染色せんしょく体たい上うえ的てき基もと因いん，编码一いち种隶属ぞく肌はだ凝しこり蛋白たんぱく超ちょう家族かぞく的てき非ひ典型てんけい的てき肌はだ凝しこり蛋白たんぱく肌はだ凝しこり蛋白たんぱく-Va（Myosin-Ia）。肌はだ凝しこり蛋白たんぱく-Va与あずか细胞内ない囊泡、细胞器き，以及蛋白たんぱく复合体がったい通どおり过微ほろ丝纤维运输有ゆう关^[5]^[6]^[7]^[8]^[9]^[10]。

参まいり见[编辑]

肌はだ凝しこり蛋白たんぱく

参考さんこう资料[编辑]

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000197535 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000034593 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Velvarska, Hana; Niessing, Dierk. Structural Insights into the Globular Tails of the Human Type V Myosins Myo5a, Myo5b, and Myo5c. PLOS ONE. 2013-12-10, 8 (12): e82065. Bibcode:2013PLoSO...882065V. ISSN 1932-6203. PMC 3858360 . PMID 24339992. doi:10.1371/journal.pone.0082065.
^ Wöllert, Torsten; Patel, Anamika; Lee, Ying-Lung; Provance, D. William; Vought, Valarie E.; Cosgrove, Michael S.; Mercer, John A.; Langford, George M. Myosin5a Tail Associates Directly with Rab3A-containing Compartments in Neurons. The Journal of Biological Chemistry. 2011-04-22, 286 (16): 14352–14361. ISSN 0021-9258. PMC 3077635 . PMID 21349835. doi:10.1074/jbc.M110.187286.
^ Schumacher-Bass, Sarah M.; Vesely, Eileen D.; Zhang, Lian; Ryland, Katherine E.; McEwen, Dyke P.; Chan, Priscilla J.; Frasier, Chad R.; McIntyre, Jeremy C.; Shaw, Robin M.; Martens, Jeffrey R. A Role for Myosin V Motor Proteins in the Selective Delivery of Kv Channel Isoforms to the Membrane Surface of Cardiac Myocytes. Circulation Research. 2014-03-14, 114 (6): 982–992. ISSN 0009-7330. PMC 4213814 . PMID 24508725. doi:10.1161/CIRCRESAHA.114.302711.
^ Engle LJ, Kennett RH. Cloning, analysis, and chromosomal localization of myoxin (MYH12), the human homologue to the mouse dilute gene. Genomics. Feb 1994, 19 (3): 407–16. PMID 8188282. doi:10.1006/geno.1994.1088.
^ Bement WM, Hasson T, Wirth JA, Cheney RE, Mooseker MS. Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. Proceedings of the National Academy of Sciences of the United States of America. Jul 1994, 91 (14): 6549–53. Bibcode:1994PNAS...91.6549B. PMC 44240 . PMID 8022818. doi:10.1073/pnas.91.14.6549.
^ Entrez Gene: MYO5A myosin VA (heavy chain 12, myoxin).

这是一いち篇へん與あずか生物せいぶつ化學かがく相關そうかん的てき小しょう作品さくひん。你可以通过编辑或ある修おさむ订扩充其内容ないよう。

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000197535 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000034593 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[:0-5] Velvarska, Hana; Niessing, Dierk. Structural Insights into the Globular Tails of the Human Type V Myosins Myo5a, Myo5b, and Myo5c. PLOS ONE. 2013-12-10, 8 (12): e82065. Bibcode:2013PLoSO...882065V. ISSN 1932-6203. PMC 3858360 . PMID 24339992. doi:10.1371/journal.pone.0082065.

[:1-6] Wöllert, Torsten; Patel, Anamika; Lee, Ying-Lung; Provance, D. William; Vought, Valarie E.; Cosgrove, Michael S.; Mercer, John A.; Langford, George M. Myosin5a Tail Associates Directly with Rab3A-containing Compartments in Neurons. The Journal of Biological Chemistry. 2011-04-22, 286 (16): 14352–14361. ISSN 0021-9258. PMC 3077635 . PMID 21349835. doi:10.1074/jbc.M110.187286.

[:2-7] Schumacher-Bass, Sarah M.; Vesely, Eileen D.; Zhang, Lian; Ryland, Katherine E.; McEwen, Dyke P.; Chan, Priscilla J.; Frasier, Chad R.; McIntyre, Jeremy C.; Shaw, Robin M.; Martens, Jeffrey R. A Role for Myosin V Motor Proteins in the Selective Delivery of Kv Channel Isoforms to the Membrane Surface of Cardiac Myocytes. Circulation Research. 2014-03-14, 114 (6): 982–992. ISSN 0009-7330. PMC 4213814 . PMID 24508725. doi:10.1161/CIRCRESAHA.114.302711.

[pmid8188282-8] Engle LJ, Kennett RH. Cloning, analysis, and chromosomal localization of myoxin (MYH12), the human homologue to the mouse dilute gene. Genomics. Feb 1994, 19 (3): 407–16. PMID 8188282. doi:10.1006/geno.1994.1088.

[pmid8022818-9] Bement WM, Hasson T, Wirth JA, Cheney RE, Mooseker MS. Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. Proceedings of the National Academy of Sciences of the United States of America. Jul 1994, 91 (14): 6549–53. Bibcode:1994PNAS...91.6549B. PMC 44240 . PMID 8022818. doi:10.1073/pnas.91.14.6549.

[entrez-10] Entrez Gene: MYO5A myosin VA (heavy chain 12, myoxin).

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