凝しこり溶胶蛋白たんぱく

Gelsolin; 凝しこり溶胶蛋白たんぱく
	PDB rendering based on 1c0f.
有效ゆうこう结构
PDB	直系ちょっけい同どう源みなもと检索：PDBe, RCSB
PDB查询代だい码列表ひょう
	1C0F, 1C0G, 1D4X, 1DEJ, 1EQY, 1ESV, 1H1V, 1KCQ, 1MDU, 1NLV, 1NM1, 1NMD, 1P8X, 1P8Z, 1SOL, 1T44, 1YAG, 1YVN, 2FF3, 2FF6, 2FH1, 2FH2, 2FH3, 2FH4, 3A5L, 3A5M, 3A5N, 3A5O, 3CI5, 3CIP, 3CJB, 3CJC, 3FFK, 3FFN, 3TU5
标识
代だい号ごう	GSN; ADF; AGEL
扩展标识	遗传学がく：137350 鼠ねずみ基もと因いん：95851 同どう源みなもと基はじめ因いん：147 GeneCards: GSN Gene
基もと因いん本体ほんたい论描述じゅつ
分子ぶんし功こう能のう	· actin binding; · calcium ion binding; · protein binding;
细胞成分せいぶん	· ruffle; · extracellular region; · extracellular space; · cytosol; · actin cytoskeleton; · lamellipodium; · protein complex; · perinuclear region of cytoplasm; · extracellular vesicular exosome;
生物せいぶつ过程	· apoptotic process; · cellular component disassembly involved in execution phase of apoptosis; · aging; · oligodendrocyte development; · vesicle-mediated transport; · actin filament polymerization; · regulation of cell adhesion; · tissue regeneration; · response to ethanol; · phosphatidylinositol-mediated signaling; · actin filament severing; · barbed-end actin filament capping; · response to folic acid; · cilium morphogenesis; · cellular response to cadmium ion;
	Sources: Amigo / QuickGO
RNA表ひょう达模式しき
	更さら多た表ひょう达数据すえ
直系ちょっけい同どう源みなもと体たい
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凝しこり溶胶蛋白たんぱく（英語えいご：Gelsolin）是ぜ一いち种肌はだ动蛋白しろ结合蛋白たんぱく，是ぜ肌はだ动蛋白しろ丝装配はい和解わかい聚调节的关键。凝しこり溶胶蛋白たんぱく是ぜ肌はだ动蛋白しろ结合蛋白たんぱく中ちゅう凝しこり溶胶蛋白たんぱく/绒毛蛋白たんぱく（英えい语：villin）超ちょう家族かぞく的てき重要じゅうよう成なり员^[1]。凝しこり溶胶蛋白たんぱく表ひょう达于细胞内ない（在ざい细胞质基质和わ线粒体たい）以及细胞外がい（血ち浆）^[2]。

结构[编辑]

凝しこり溶胶蛋白たんぱく是ぜ一いち个82千道尔顿的蛋白质，具有ぐゆう六个同源亚结构域，称しょう为S1-S6。每まい个亚结构域いき都と包つつみ含有がんゆう五ご片へんβべーた折おり叠，旁つくり边缀有ゆう两个αあるふぁ螺旋らせん，一いち个垂直すいちょく，另一个平行へいこう于βべーた折おり叠片。其N端はし（S1-S3）和わC端はし（S4-S6）各自かくじ组成了りょう一いち个额外的がいてきβべーた折おり叠^[3]。

参考さんこう文献ぶんけん[编辑]

^ Sun HQ, Yamamoto M, Mejillano M, Yin HL. Gelsolin, a multifunctional actin regulatory protein. J. Biol. Chem. November 1999, 274 (47): 33179–82. PMID 10559185. doi:10.1074/jbc.274.47.33179.
^ Koya RC, Fujita H, Shimizu S, Ohtsu M, Takimoto M, Tsujimoto Y, Kuzumaki N. Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release. J. Biol. Chem. May 2000, 275 (20): 15343–9. PMID 10809769. doi:10.1074/jbc.275.20.15343.
^ Kiselar JG, Janmey PA, Almo SC, Chance MR. Visualizing the Ca2+-dependent activation of gelsolin by using synchrotron footprinting. Proc. Natl. Acad. Sci. U.S.A. April 2003, 100 (7): 3942–7. PMC 153027 . PMID 12655044. doi:10.1073/pnas.0736004100.

外部がいぶ链接[编辑]

醫學いがく主題しゅだい詞し表ひょう（MeSH）：Gelsolin

[Sun-1] Sun HQ, Yamamoto M, Mejillano M, Yin HL. Gelsolin, a multifunctional actin regulatory protein. J. Biol. Chem. November 1999, 274 (47): 33179–82. PMID 10559185. doi:10.1074/jbc.274.47.33179.

[Koya-2] Koya RC, Fujita H, Shimizu S, Ohtsu M, Takimoto M, Tsujimoto Y, Kuzumaki N. Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release. J. Biol. Chem. May 2000, 275 (20): 15343–9. PMID 10809769. doi:10.1074/jbc.275.20.15343.

[Kiselar-3] Kiselar JG, Janmey PA, Almo SC, Chance MR. Visualizing the Ca2+-dependent activation of gelsolin by using synchrotron footprinting. Proc. Natl. Acad. Sci. U.S.A. April 2003, 100 (7): 3942–7. PMC 153027 . PMID 12655044. doi:10.1073/pnas.0736004100.

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