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Gene Symbol(s):
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RELA
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| Organism: |
Homo sapiens |
| View Gene in Tree |
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| Gene Name: |
Transcription factor p65
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| Gene ID: |
HGNC:9955
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| Protein ID: |
Q04206
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| Enhancers: |
View enhancers for HUMAN|HGNC=9955|UniProtKB=Q04206 |
| Genetic Variant Annotation: |
Annoq |
| Persistent Id: |
PTN002516588 |
| Alternate Ids: |
| HGNC:9955(HGNC) |
5970(GeneID) |
| 164014(MIM) |
4558611(GI) |
| NFKB3(Synonym) |
CHEMBL5533(ChEMBL) |
| L19067(EMBL) |
Q6SLK1(AltAccession) |
| ENSG00000173039(Ensembl) |
AAA36408(EMBL-CDS) |
| RELA(Symbol) |
TF65_HUMAN(UniProtKB-ID) |
NP_001230913(refSeq) |
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Show All
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| GO MF Complete: |
RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, transcription cis-regulatory region binding, DNA-binding transcription activator activity, RNA polymerase II-specific, peptide binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, transcription coactivator binding, DNA-binding transcription factor activity, ankyrin repeat binding, general transcription initiation factor binding, DNA-binding transcription factor binding, chromatin DNA binding, protein kinase binding, identical protein binding, protein homodimerization activity, histone deacetylase binding, actinin binding, chromatin binding, phosphate ion binding, DNA-binding transcription factor activity, RNA polymerase II-specific, NF-kappaB binding, DNA binding, ubiquitin protein ligase binding, protein binding, enzyme binding
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| GO BP Complete: |
negative regulation of angiogenesis, response to muramyl dipeptide, response to progesterone, positive regulation of non-canonical NF-kappaB signal transduction, negative regulation of protein catabolic process, negative regulation of non-canonical NF-kappaB signal transduction, chromatin organization, positive regulation of NF-kappaB transcription factor activity, defense response to tumor cell, inflammatory response, hair follicle development, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, defense response to virus, response to muscle stretch, intracellular signal transduction, positive regulation of miRNA metabolic process, positive regulation of vascular endothelial growth factor production, cellular response to angiotensin, response to organic substance, toll-like receptor 4 signaling pathway, non-canonical NF-kappaB signal transduction, positive regulation of amyloid-beta formation, negative regulation of insulin receptor signaling pathway, animal organ morphogenesis, cellular defense response, tumor necrosis factor-mediated signaling pathway, neuropeptide signaling pathway, positive regulation of interleukin-8 production, nucleotide-binding oligomerization domain containing 2 signaling pathway, positive regulation of gene expression, response to interleukin-1, regulation of inflammatory response, positive regulation of interleukin-6 production, response to UV-B, response to cytokine, negative regulation of miRNA transcription, positive regulation of cell population proliferation, response to amino acid, positive regulation of Schwann cell differentiation, positive regulation of canonical NF-kappaB signal transduction, response to cAMP, positive regulation of miRNA transcription, response to xenobiotic stimulus, positive regulation of leukocyte adhesion to vascular endothelial cell, positive regulation of transcription by RNA polymerase II, negative regulation of transcription by RNA polymerase II, response to ischemia, response to insulin, cellular response to interleukin-6, cytokine-mediated signaling pathway, liver development, cellular response to stress, postsynapse to nucleus signaling pathway, cellular response to tumor necrosis factor, negative regulation of protein sumoylation, cellular response to hydrogen peroxide, cellular response to nicotine, response to cobalamin, DNA-templated transcription, protein catabolic process, prolactin signaling pathway, vascular endothelial growth factor signaling pathway, regulation of DNA-templated transcription, canonical NF-kappaB signal transduction, acetaldehyde metabolic process, regulation of transcription by RNA polymerase II, positive regulation of T cell receptor signaling pathway, positive regulation of interleukin-12 production, cellular response to lipopolysaccharide, cellular response to lipoteichoic acid, cellular response to hepatocyte growth factor stimulus, innate immune response, negative regulation of apoptotic process, cellular response to interleukin-1, negative regulation of extrinsic apoptotic signaling pathway, interleukin-1-mediated signaling pathway, cellular response to peptidoglycan, positive regulation of interleukin-1 beta production
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| GO CC Complete: |
nucleus, transcription regulator complex, cytoplasm, NF-kappaB p50/p65 complex, cytosol, NF-kappaB complex, glutamatergic synapse, chromatin, nucleoplasm
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| Reactome Pathways: |
Cellular Senescence, Fc epsilon receptor (FCERI) signaling, Senescence-Associated Secretory Phenotype (SASP), Toll Like Receptor 2 (TLR2) Cascade, Chromatin modifying enzymes, RNA Polymerase II Transcription, Interleukin-1 family signaling, Cellular responses to stimuli, Toll Like Receptor 10 (TLR10) Cascade, Cell recruitment (pro-inflammatory response), ZBP1(DAI) mediated induction of type I IFNs, Infectious disease, Toll Like Receptor 7/8 (TLR7/8) Cascade, KEAP1-NFE2L2 pathway, Downstream TCR signaling, Purinergic signaling in leishmaniasis infection, The NLRP3 inflammasome, SUMOylation, MyD88-independent TLR4 cascade , Toll Like Receptor TLR6:TLR2 Cascade, SARS-CoV-1 Infection, Transcriptional Regulation by VENTX, TRIF(TICAM1)-mediated TLR4 signaling , FCERI mediated NF-kB activation, RIP-mediated NFkB activation via ZBP1, C-type lectin receptors (CLRs), TRAF6 mediated NF-kB activation, NF-kB is activated and signals survival, Toll Like Receptor 4 (TLR4) Cascade, Cellular response to chemical stress, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Parasitic Infection Pathways, IkBA variant leads to EDA-ID, Nuclear events mediated by NFE2L2, Gene expression (Transcription), MyD88 cascade initiated on plasma membrane, Diseases of Immune System, Viral Infection Pathways, MyD88 dependent cascade initiated on endosome, Regulated proteolysis of p75NTR, SUMO E3 ligases SUMOylate target proteins, Transcriptional regulation of white adipocyte differentiation, Inflammasomes, Cellular responses to stress, PKMTs methylate histone lysines, Signaling by Interleukins, Post-translational protein modification, Toll Like Receptor 3 (TLR3) Cascade, p75NTR signals via NF-kB, CLEC7A (Dectin-1) signaling, DEx/H-box helicases activate type I IFN and inflammatory cytokines production , Dectin-1 mediated noncanonical NF-kB signaling, Signal Transduction, TCR signaling, Innate Immune System, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Cytosolic sensors of pathogen-associated DNA , Developmental Biology, SARS-CoV-1-host interactions, Activation of NF-kappaB in B cells, Chromatin organization, DDX58/IFIH1-mediated induction of interferon-alpha/beta, SARS-CoV-1 activates/modulates innate immune responses, Interleukin-1 signaling, TAK1-dependent IKK and NF-kappa-B activation , Death Receptor Signaling, Metabolism of proteins, CLEC7A/inflammasome pathway, Generic Transcription Pathway, Toll Like Receptor 5 (TLR5) Cascade, Disease, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, Leishmania infection, Regulation of NFE2L2 gene expression, p75 NTR receptor-mediated signalling, Downstream signaling events of B Cell Receptor (BCR), Toll-like Receptor Cascades, CD209 (DC-SIGN) signaling, Toll Like Receptor 9 (TLR9) Cascade, Signaling by the B Cell Receptor (BCR), Cytokine Signaling in Immune system, SUMOylation of immune response proteins, Diseases associated with the TLR signaling cascade, Toll Like Receptor TLR1:TLR2 Cascade, Immune System, Adaptive Immune System, SARS-CoV Infections, Interleukin-1 processing
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