hERG
hERG (ヒト
構造
[hERGカリウムチャンネルは、それぞれ6
遺伝 学
[このイオンチャンネルの
薬物 相互 作用
[このイオンチャンネルは、
このような
名称 の由来
[hERGは、1960
脚注
[- ^ Sanguinetti MC, Jiang C, Curran ME, Keating MT (1995). “A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel”. Cell 81 (2): 299–307. doi:10.1016/0092-8674(95)90340-2. PMID 7736582.
- ^ Moss AJ, Zareba W, Kaufman ES, Gartman E, Peterson DR, Benhorin J, Towbin JA, Keating MT, Priori SG, Schwartz PJ, Vincent GM, Robinson JL, Andrews ML, Feng C, Hall WJ, Medina A, Zhang L, Wang Z (2002). “Increased risk of arrhythmic events in long-QT syndrome with mutations in the pore region of the human ether-a-go-go-related gene potassium channel”. Circulation 105 (7): 794–9. doi:10.1161/hc0702.105124. PMID 11854117.
- ^ Sanguinetti MC, Tristani-Firouzi M (2006). “hERG potassium channels and cardiac arrhythmia”. Nature 440 (7083): 463–9. doi:10.1038/nature04710. PMID 16554806.
- ^ Milnes JT, Crociani O, Arcangeli A, Hancox JC, Witchel HJ (2003). “Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652”. Br J Pharmacol 139 (5): 887–98. doi:10.1038/sj.bjp.0705335. PMID 12839862.
- ^ Kerns, E. H.; Di, L. (2008). Drug-like properties: concepts, structure design and methods from ADME to toxicity optimization. Burlington, Massachusetts: Academic press. pp. 212. ISBN 978-01236-9520-8
参考 文献
[- "The molecular genetics of the long QT syndrome: genes causing fainting and sudden death" Annu. Rev. Med., 49, pp. 263–74 (1998).
- "The long QT syndrome: ion channel diseases of the heart" Mayo Clin. Proc., 73(3), pp. 250–69 (1998).
- Taglialatela M, Castaldo P, Pannaccione A, et al. "Human ether-a-gogo related gene (HERG) K+ channels as pharmacological targets: present and future implications" Biochem. Pharmacol., 55(11), pp. 1741–6 (1998) .
- Bjerregaard P, Gussak I "Short QT syndrome: mechanisms, diagnosis and treatment" Nature clinical practice. Cardiovascular medicine, 2(2), pp. 84–7 (2005).
- Gutman GA, Chandy KG, Grissmer S, et al. "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels" Pharmacol. Rev., 57(4), pp. 473–508 (2006).