トロポミオシン受容 体 キナーゼC
トロポミオシン
TrkC
機能
[TrkCは、ニューロトロフィン3(NTF3、NT-3)に
さらに、TrkCは
NTRK3
Trk受容 体 ファミリーのメンバー
[トロポミオシン
TrkCは
疾患 における役割
[NT-3またはTrkCのいずれかを
アルツハイマー
さらに、TrkCはがんとも
がんにおける役割
[Trkファミリーが
NTRK3のメチル化
[NTRK3のプロモーター
TrkC阻害 薬
[エヌトレクチニブ(RXDX-101)はIgnytaによって
相互 作用
[NTRK3は
- SH2B2
- SQSTM1
- KIDINS220
- PTPRS[29]
- MAPK8IP3
- NTF3[30][31][32][33][34]
- TGFBR2[35]
- DOK5[36]
- BMPR2[37]
- PLCG1[38][39]
リガンド
[TrkC
出典
[- ^ a b c GRCh38: Ensembl release 89: ENSG00000140538 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059146 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Chapter 8: Atypical neurotransmitters”. Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd ed.). New York: McGraw-Hill Medical. (2009). ISBN 978-0-07-148127-4. "Another common feature of neurotrophins is that they produce their physiologic effects by means of the tropomyosin receptor kinase (Trk) receptor family (also known as the tyrosine receptor kinase family). ... Try receptors. All neurotrophins bind to a class of highly homologous receptor tyrosine kinases known as Trk receptors, of which three types are known: TrkA, TrkB, and TrkC. These transmembrane receptors are glycoproteins whose molecular masses range from 140 to 145 kDa. Each type of Trk receptor tends to bind specific neurotrophins: TrkA is the receptor for NGF, TrkB the receptor for BDNF and NT-4, and TrkC the receptor for NT-3.However, some overlap in the specificity of these receptors has been noted."
- ^ “Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant”. Genomics 22 (2): 267–72. (July 1994). doi:10.1006/geno.1994.1383. PMID 7806211.
- ^ Tsoulfas, P. (2018). “Signaling by NTRK3 (TRKC)”. Reactome - A Curated Knowledgebase of Biological Pathways 65. doi:10.3180/R-HSA-9034015.1 .
- ^ “Postsynaptic TrkC and presynaptic PTP
σ function as a bidirectional excitatory synaptic organizing complex”. Neuron 69 (2): 287–303. (January 2011). doi:10.1016/j.neuron.2010.12.024. PMC 3056349. PMID 21262467 . - ^ “TrkC isoforms with inserts in the kinase domain show impaired signaling responses”. The Journal of Biological Chemistry 271 (10): 5691–7. (March 1996). doi:10.1074/jbc.271.10.5691. PMID 8621434.
- ^ “Emerging roles of the neurotrophin receptor TrkC in synapse organization”. Neuroscience Research 116 (2017): 10–17. (March 2017). doi:10.1016/j.neures.2016.09.009. PMID 27697534.
- ^ “Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children”. The New England Journal of Medicine 378 (8): 731–739. (February 2018). doi:10.1056/NEJMoa1714448. PMC 5857389. PMID 29466156 .
- ^ “Origin and evolution of the Trk family of neurotrophic receptors”. Molecular and Cellular Neurosciences 31 (2): 179–92. (February 2006). doi:10.1016/j.mcn.2005.09.007. PMID 16253518 .
- ^ “Neurotrophin-3 production promotes human neuroblastoma cell survival by inhibiting TrkC-induced apoptosis”. The Journal of Clinical Investigation 120 (3): 850–8. (March 2010). doi:10.1172/jci41013. PMC 2827960. PMID 20160348 .
- ^ “Neurotrophic factors and their receptors”. Current Opinion in Cell Biology 7 (2): 148–55. (April 1995). doi:10.1016/0955-0674(95)80022-0. PMID 7612265.
- ^ “Roles of TrkC Signaling in the Regulation of Tumorigenicity and Metastasis of Cancer”. Cancers 12 (1): 147. (January 2020). doi:10.3390/cancers12010147. PMC 7016819. PMID 31936239 ..
- ^ “Neuroprotection: Pro-survival and Anti-neurotoxic Mechanisms as Therapeutic Strategies in Neurodegeneration”. Frontiers in Cellular Neuroscience 13 (231): 231. (31 January 2019). doi:10.3389/fncel.2019.00231. PMC 6563757. PMID 31244606 .
- ^ “Tropomyosin Receptor Kinase C Targeted Delivery of a Peptidomimetic Ligand-Photosensitizer Conjugate Induces Antitumor Immune Responses Following Photodynamic Therapy”. Scientific Reports 6 (37209): 37209. (November 2016). doi:10.1038/srep37209. PMC 5112560. PMID 27853305 .
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- ^ “An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101”. Cancer Discovery 5 (10): 1049–57. (October 2015). doi:10.1158/2159-8290.CD-15-0443. PMC 4635026. PMID 26216294 .
- ^ “TrkC plays an essential role in breast tumor growth and metastasis”. Carcinogenesis 31 (11): 1939–47. (November 2010). doi:10.1093/carcin/bgq180. PMID 20802235.
- ^ “Trk receptor expression and inhibition in neuroblastomas”. Clinical Cancer Research 15 (10): 3244–50. (May 2009). doi:10.1158/1078-0432.ccr-08-1815. PMC 4238907. PMID 19417027 .
- ^ “
β -Phenethyl isothiocyanate induces death receptor 5 to induce apoptosis in human oral cancer cells via p38”. Oral Diseases 18 (5): 513–9. (July 2012). doi:10.1111/j.1601-0825.2012.01905.x. PMID 22309674. - ^ “TrkC expression predicts good clinical outcome in primitive neuroectodermal brain tumors”. Journal of Clinical Oncology 18 (5): 1027–35. (March 2000). doi:10.1200/jco.2000.18.5.1027. PMID 10694553.
- ^ “NTRK3 is a potential tumor suppressor gene commonly inactivated by epigenetic mechanisms in colorectal cancer”. PLOS Genetics 9 (7): e1003552. (2013-07-11). doi:10.1371/journal.pgen.1003552. PMC 3708790. PMID 23874207 .
- ^ “Detection of aberrant methylated SEPT9 and NTRK3 genes in sporadic colorectal cancer patients as a potential diagnostic biomarker”. Oncology Letters 12 (6): 5335–5343. (December 2016). doi:10.3892/ol.2016.5327. PMC 5228494. PMID 28105243 .
- ^ “Prognostic CpG methylation biomarkers identified by methylation array in esophageal squamous cell carcinoma patients”. International Journal of Medical Sciences 11 (8): 779–87. (2014). doi:10.7150/ijms.7405. PMC 4057483. PMID 24936140 .
- ^ “Evaluating entrectinib as a treatment option for non-small cell lung cancer”. Expert Opinion on Pharmacotherapy 21 (16): 1935–1942. (November 2020). doi:10.1080/14656566.2020.1798932. PMID 32736487.
- ^ “FDA Approval Summary: Entrectinib for the Treatment of NTRK gene Fusion Solid Tumors”. Clinical Cancer Research 27 (4): 928–932. (February 2021). doi:10.1158/1078-0432.CCR-20-2771. PMID 32967940.
- ^ “Structural basis for extracellular cis and trans RPTP
σ signal competition in synaptogenesis”. Nature Communications 5 (5209): 5209. (November 2014). doi:10.1038/ncomms6209. PMC 4239663. PMID 25385546 . - ^ Lamballe, L; Klein, R; Barbecid, M (6 September 1991). “TrkC, a new member of the TrkC family of tyrosine protein kinases, is a receptor for Neurotrophin-3”. Cell 66 (5): 967–979. doi:10.1016/0092-8674(91)90442-2. PMID 1653651.
- ^ Philo, J; Talvenheimo, J; Wen, J; Rosenfeld, R; Welcher, A; Arakawa, T (11 November 1994). “Interactions of Neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and the NT-3. BDNF heterodimer with the extracellular domains of the TrkB and TrkC receptors”. Journal of Biological Chemistry 269 (45): 27840–27846. doi:10.1016/S0021-9258(18)46863-9. PMID 7961713.
- ^ “TrkC isoforms with inserts in the kinase domain show impaired signaling responses”. The Journal of Biological Chemistry 271 (10): 5691–7. (March 1996). doi:10.1074/jbc.271.10.5691. PMID 8621434.
- ^ “Neurotrophins: roles in neuronal development and function”. Annual Review of Neuroscience 24: 677–736. (March 2001). doi:10.1146/annurev.neuro.24.1.677. PMC 2758233. PMID 11520916 .
- ^ “Mutations in NTRK3 suggest a novel signaling pathway in human congenital heart disease”. Human Mutation 35 (12): 1459–68. (December 2014). doi:10.1002/humu.22688. PMC 4247247. PMID 25196463 .
- ^ “TrkC binds to the type II TGF-beta receptor to suppress TGF-beta signaling”. Oncogene 26 (55): 7684–91. (December 2007). doi:10.1038/sj.onc.1210571. PMID 17546043.
- ^ “Dok5 is substrate of TrkB and TrkC receptors and involved in neurotrophin induced MAPK activation”. Cellular Signalling 18 (11): 1995–2003. (November 2006). doi:10.1016/j.cellsig.2006.03.007. PMID 16647839.
- ^ “TrkC binds to the bone morphogenetic protein type II receptor to suppress bone morphogenetic protein signaling”. Cancer Research 67 (20): 9869–77. (October 2007). doi:10.1158/0008-5472.CAN-07-0436. PMID 17942918.
- ^ “Neurotrophin-3 and brain-derived neurotrophic factor activate multiple signal transduction events but are not survival factors for hippocampal pyramidal neurons”. Journal of Neurochemistry 67 (3): 952–63. (September 1996). doi:10.1046/j.1471-4159.1996.67030952.x. PMID 8752100.
- ^ “Early BDNF, NT-3, and NT-4 signaling events”. Experimental Neurology 159 (1): 297–308. (September 1999). doi:10.1006/exnr.1999.7148. PMID 10486198.
- ^ “Selective small molecule peptidomimetic ligands of TrkC and TrkA receptors afford discrete or complete neurotrophic activities”. Chemistry & Biology 12 (9): 1015–28. (September 2005). doi:10.1016/j.chembiol.2005.06.015. PMID 16183026.
- ^ “A peptidomimetic of NT-3 acts as a TrkC antagonist”. Peptides 30 (10): 1833–9. (October 2009). doi:10.1016/j.peptides.2009.07.015. PMC 2755609. PMID 19647025 .
関連 文献
[- “trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3”. Cell 66 (5): 967–79. (September 1991). doi:10.1016/0092-8674(91)90442-2. PMID 1653651.
- “trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues”. Development 118 (2): 463–75. (June 1993). doi:10.1242/dev.118.2.463. PMID 8223273.
- “Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements”. Nature 368 (6468): 249–51. (March 1994). Bibcode: 1994Natur.368..249K. doi:10.1038/368249a0. PMID 8145824.
- “Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells”. Neuron 10 (2): 137–49. (February 1993). doi:10.1016/0896-6273(93)90306-C. PMID 7679912.
- “Function and evolution in the NGF family and its receptors”. Journal of Neuroscience Research 32 (4): 461–70. (August 1992). doi:10.1002/jnr.490320402. PMID 1326636.
- “Naturally occurring tyrosine kinase inserts block high affinity binding of phospholipase C gamma and Shc to TrkC and neurotrophin-3 signaling”. The Journal of Biological Chemistry 270 (35): 20384–90. (September 1995). doi:10.1074/jbc.270.35.20384. PMID 7657612.
- “Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins”. The Journal of Neuroscience 15 (1 Pt 2): 477–91. (January 1995). doi:10.1523/JNEUROSCI.15-01-00477.1995. PMC 6578290. PMID 7823156 .
- “Expression of a Trk high affinity nerve growth factor receptor in the human prostate”. Endocrinology 136 (1): 262–8. (January 1995). doi:10.1210/endo.136.1.7828539. PMID 7828539.
- “trkC encodes multiple neurotrophin-3 receptors with distinct biological properties and substrate specificities”. The EMBO Journal 12 (8): 3083–94. (August 1993). doi:10.1002/j.1460-2075.1993.tb05977.x. PMC 413573. PMID 8344249 .
- “A "double adaptor" method for improved shotgun library construction”. Analytical Biochemistry 236 (1): 107–13. (April 1996). doi:10.1006/abio.1996.0138. PMID 8619474.
- “Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and nonneural tissues”. Neurochemical Research 21 (8): 929–38. (August 1996). doi:10.1007/BF02532343. PMID 8895847.
- “Large-scale concatenation cDNA sequencing”. Genome Research 7 (4): 353–8. (April 1997). doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174 .
- “Mapping of the tyrosine kinase receptors trkA (NTRK1), trkB (NTRK2) and trkC(NTRK3) to human chromosomes 1q22, 9q22 and 15q25 by fluorescence in situ hybridization”. European Journal of Human Genetics 5 (2): 102–4. (1997). doi:10.1159/000484742. PMID 9195161.
- “trkA and trkC expression is increased in human diabetic skin”. Neuroscience Letters 228 (1): 33–6. (May 1997). doi:10.1016/S0304-3940(97)00350-9. PMID 9197281.
- “A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma”. Nature Genetics 18 (2): 184–7. (February 1998). doi:10.1038/ng0298-184. PMID 9462753.
- “High resolution mapping of the binding site of TrkA for nerve growth factor and TrkC for neurotrophin-3 on the second immunoglobulin-like domain of the Trk receptors”. The Journal of Biological Chemistry 273 (10): 5829–40. (March 1998). doi:10.1074/jbc.273.10.5829. PMID 9488719.
- “Inhibition of phosphorylation of TrkB and TrkC and their signal transduction by alpha2-macroglobulin”. Journal of Neurochemistry 71 (1): 213–20. (July 1998). doi:10.1046/j.1471-4159.1998.71010213.x. PMID 9648868.
- “Genomic characterization of the human trkC gene”. Oncogene 17 (14): 1871–5. (October 1998). doi:10.1038/sj.onc.1202100. PMID 9778053.
- “Identification and characterization of novel substrates of Trk receptors in developing neurons”. Neuron 21 (5): 1017–29. (November 1998). doi:10.1016/S0896-6273(00)80620-0. PMID 9856458.
- “Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR”. The EMBO Journal 18 (3): 616–22. (February 1999). doi:10.1093/emboj/18.3.616. PMC 1171154. PMID 9927421 .
- “Expression of neurotrophins and their receptors in human bone marrow”. The American Journal of Pathology 154 (2): 405–15. (February 1999). doi:10.1016/s0002-9440(10)65287-x. PMC 1849993. PMID 10027399 .